Medical hydrogel wound dressing and preparation method thereof

Abstract

The invention discloses a preparation method of a medical hydrogel wound dressing, 20 to 30 percent by weight of sodium polyacrylate, 2 to 6 percent by weight of polyvinyl alcohol and 60 to 78 percent by weight of water are taken as raw materials, the medical hydrogel wound dressing is obtained by casting, radiation cross-linking grafting and sterilization, the radiation dose rate is 15kGy / time, and the dose is 30 to 90kGy. The hydrogel wound dressing obtained by the invention has very high swelling degree and can greatly reduce the replacement of the dressing and be doped with a cell growth factor for slow release, thus being the ideal wound dressing for treating various burns, scalds, trauma wounds and other wounds, more particularly, the large-area and hypertonic skin wounds; furthermore, the preparation process is simple and the cost is slow, thus having good industrial application prospect.

Description

Technical field [0001] The invention relates to a dressing and a preparation method thereof, in particular to a super absorbent medical hydrogel wound dressing and a preparation method thereof. Background technique [0002] At present, the treatment of burns, scalds, wounds and other traumatic wounds and wounds in clinical medicine generally adopts wet therapy, that is, wound dressings are wrapped on the wound surface to keep the wound in a moist state for a long time to reduce pain and accelerate the wound heal. Existing wound dressings mainly include three types, namely universal type, biological type and composite type. Among them, composite type wound dressing mainly refers to hydrogel wound dressing, namely, a certain concentration of high molecular polymer such as polyvinyl alcohol and polyacrylic acid. Sodium, polyethylene oxide, polyvinylpyrrolidone, polyacrylic acid, partially neutralized polyacrylic acid, polyethylene oxide, polyacrylamide and other solutions are cross-...

AI Technical Summary

Problems solved by technology

However, this preparation method and the resulting hydrogel film have the following disadvantages: 1. The swelling degree of the hydrogel wound dressing obtained by the preparation method is only about 1900%, and its ability to absorb wound exudate and maintain a wound moist environment is relatively low. Weak, it needs to be replaced within 1-2 days of clinical use, which not only increases the workload of medical staff for frequent replacement, but also causes waste of medical supplies such as hydrogel wound dressings, and more importantly, frequent replacement of dressings will cause wound infection , Secondary injury, especially the situation of large area and high exudation skin wound; ②The preparation method includes cold and hot cycle treatment steps, which consumes a lot of energy and also increases the complexity of the process

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