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Meshy degradable blood vessel stent and preparation method thereof

The technology of a vascular stent and a mesh stent is applied in the field of mesh degradable vascular stent and its preparation, and achieves the effects of less inflammatory reaction, less restenosis in the stent, and enhanced treatment and diagnosis.

Inactive Publication Date: 2011-05-11
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a mesh-shaped degradable vascular stent and its preparation method, which solves many problems of metal stents used in current vascular interventional treatment, and enhances the detection of vascular diseases by coating drugs and / or X-ray contrast agents. Treatment and Diagnosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 : Preparation of Mesh Degradable Vascular Stent

[0029] Take the total mass 80% The polylactic acid (molecular weight is 15 million) and total mass 1% Nucleating agent, after vacuum drying, mix the raw materials evenly to get the mixed raw materials; 160℃ Under the condition of temperature, the mixed raw materials are made by self-made equipment with a diameter of 0.3mm The degradable filaments are woven into a mesh bracket on a mold of a certain shape, and the outer diameter of the bracket is 8mm ,long 50mm ; add dichloromethane to reduce the total mass 10% The polylactic acid (molecular weight is 8 million) and total mass 9% Rapamycin 0.10g / ml The solution is sprayed to form a film on the surface of the mesh stent, and finally sterilized by fumigation with ethylene peroxide to obtain the mesh degradable vascular stent.

Embodiment 2

[0030] Example 2 : Preparation of Mesh Degradable Vascular Stent

[0031] Take the total mass 50% The polylactic acid (molecular weight is 20 million), the total mass 30% Polycaprolactone (molecular weight of 7 million) and total mass 1% Nucleating agent, after vacuum drying, mix the raw materials evenly to get the mixed raw materials; 170℃ Under the condition of temperature, the mixed raw materials are made by self-made equipment with a diameter of 0.4mm The degradable filaments are woven into a mesh bracket on a mold of a certain shape, and the outer diameter of the bracket is 6mm ,long 40mm ; add dichloromethane to reduce the total mass10% The polylactic acid (molecular weight is 8 million) and total mass 9% of aspirin 0.10g / ml The solution is soaked to form a film on the surface of the mesh stent, and finally sterilized by fumigation with ethylene peroxide to obtain the mesh degradable vascular stent.

Embodiment 3

[0032] Example 3 : Preparation of Mesh Degradable Vascular Stent

[0033] Take the total mass 50% The polylactic acid (molecular weight is 25 million), the total mass 21% Polycaprolactone (molecular weight of 7 million) and total mass 10% plasticizer, after vacuum drying, mix the raw materials evenly to get the mixed raw materials; 160℃ Under the condition of temperature, the mixed raw materials are made by self-made equipment with a diameter of 0.4mm The degradable filaments are woven into a mesh bracket on a mold of a certain shape, and the outer diameter of the bracket is 5mm ,long 60mm ; Chloroform was added to reduce the total mass 10% The degradable polyurethane (molecular weight is 8 million) and total mass 9% of X Photodeveloper formulated 0.15g / ml The solution is sprayed to form a film on the surface of the mesh stent, and finally sterilized by fumigation with ethylene peroxide to obtain the mesh degradable vascular stent.

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Abstract

The invention relates to the technical field of medical apparatuses and instruments, in particular to a meshy degradable blood vessel stent and a preparation method thereof. The meshy degradable blood vessel stent is woven by degradable polymer filaments and has a certain shape; the filament is composed of degradable polymer and a certain content of auxiliary agent; a degradable polymer solution containing a drug and / or an X-ray developer forms a film on the surface of the meshy stent; and the degradable blood vessel stent has an automatically swelling function, has enough intensity to resist the resilience force of the arterial wall, and can automatically degrade after finishing a certain time of mechanical support on the organ tube wall; and the degraded product has no toxic and side effect on the tissue, thus a secondary operation for taking out the conduit is unnecessary, and the treatment and diagnosis on the vascular diseases are enhanced through coating the drug or the X-ray developer.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a mesh degradable vascular stent and a preparation method thereof. Background technique [0002] Interventional therapy is an emerging treatment method between surgical and medical treatments, including endovascular intervention and non-vascular interventional therapy. Vascular stents belong to vascular interventional therapy and are mainly used to treat vascular stenosis. [0003] Domestic medical catheters used for interventional treatment of vascular stenosis are basically metal stents. The surface of the metal stent used initially is bare metal. Although the bare metal stent meets the mechanical performance requirements, it has poor blood compatibility after being inserted into the human body. In addition, bare metal stents will release heavy metal ions in the blood, and these heavy metal ions will promote the formation of thrombus. At present, the coated...

Claims

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Application Information

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IPC IPC(8): A61F2/90A61L31/04A61L31/06A61L31/14A61L31/16A61L33/00
Inventor 任天斌刘秋明黄超雷雪侠文娟
Owner TONGJI UNIV
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