30 results about "Sedative agent" patented technology

One aspect of the present invention relates to pharmaceutical compositions comprising a sedative agent; and melatonin or a melatonin analog, collectively referred to as “melatonin agents.” In a preferred embodiment, the sedative agent is eszopiclone. The pharmaceutical compositions of the invention are useful in the treatment of various sleep disorders. In addition, the present invention also relates to a method of treating a patient suffering from a sleep abnormality or insomnia comprising administering a therapeutically effective amount of a pharmaceutical composition of the invention.

The present invention generally relates to pharmaceutical compositions comprising a dopamine agonist and sedative agent. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine. In a preferred embodiment, the sedative agent is optically pure (S)-zopiclone or optically pure (S)-N-desmethylzopiclone. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine; and the sedative agent is optically pure (S)-zopiclone or optically pure (S)-N-desmethylzopiclone. The pharmaceutical compositions of the invention are useful in the treatment of restless-leg syndrome and periodic-limb-movement disorder, as well as various sleep disorders. In addition, the present invention relates to a method of treating a patient suffering from restless-leg syndrome, periodic-limb-movement disorder, a sleep abnormality, or insomnia, comprising coadministering a therapeutically effective amount of a dopamine agonist and a therapeutically effective amount of a sedative agent. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine. In a preferred embodiment, the sedative agent is optically pure (S)-zopiclone or optically pure (S)-N-desmethylzopiclone. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine; and the sedative agent is optically pure (S)-zopiclone or optically pure (S)-N-desmethylzopiclone.

The present invention generally relates to pharmaceutical compositions comprising a dopamine agonist and sedative agent. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine. In a preferred embodiment, the sedative agent is optically pure (S)-zopiclone or optically pure (S)—N-desmethylzopiclone. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine; and the sedative agent is optically pure (S)-zopiclone or optically pure (S)—N-desmethylzopiclone. The pharmaceutical compositions of the invention are useful in the treatment of restless-leg syndrome and periodic-limb-movement disorder, as well as various sleep disorders. In addition, the present invention relates to a method of treating a patient suffering from restless-leg syndrome, periodic-limb-movement disorder, a sleep abnormality, or insomnia, comprising coadministering a therapeutically effective amount of a dopamine agonist and a therapeutically effective amount of a sedative agent. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine. In a preferred embodiment, the sedative agent is optically pure (S)-zopiclone or optically pure (S)—N-desmethylzopiclone. In a preferred embodiment, the dopamine agonist is optically pure (S)-didesmethylsibutramine; and the sedative agent is optically pure (S)-zopiclone or optically pure (S)—N-desmethylzopiclone.

This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as active ingredient, an opioid (μ receptor) agonist, such as fentanyl, or a salt thereof, characterized in that the composition is in the form of a fast-dispersing dosage form designed to release the active ingredient rapidly in the oral cavity. A process for preparing such a composition and the use of such a composition as an analgesic, for the treatment of chronic pain and / or breakthrough pain, as an anesthetic premedication, for the induction of anesthesia, as a sedative and / or for the treatment of anxiety are also provided.

The present invention includes systems and methods for decreasing the pain and discomfort commonly associated with endoscopic procedures, where such procedures may be performed with lower dosage levels of sedative and analgesic drugs. The invention includes use of an anesthetic collar coupled to an endoscope with a flexible shaft. The anesthetic collar allows lubricants, local anesthetics, dyes, and / or other desirable fluids to be passed through the existing lumen of the flexible shaft into an annulus, where the fluid may be distributed through expulsion pores into the gastrointestinal tract. Utilizing the existing lumens found in endoscopes, the present invention allows those fluids that may reduce the pain and discomfort associated with endoscopies such as, for example, local anesthetics and lubricants, to be distributed in an even fashion throughout the gastrointestinal tract or throughout the length and circumference of the endoscope, where such fluids may reduce the drug level requirements for sedative and analgesic agents. Alternatively, the endoscope may be redesigned for streamlined integration with the anesthetic collar or to accomplish the same function of distributing local anesthetics and lubricants, in an even fashion throughout the gastrointestinal tract or throughout the length and circumference of the endoscope, The invention can also be used with endoscopes without existing lumens.

Arylalkyl ketone piperazine derivatives of the formula:and pharmaceutical compositions comprising the same. Also disclosed are methods for using the compounds as analgesic and sedative agents. The compounds of the present invention have good analgesic and sedative activities but few side effects.

By intravenously administering a sedative comprising methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate or a salt thereof to a patient by a dosing regimen including a two-step process disclosed in the present invention, general anesthesia can be safely and promptly induced and maintained.

A method for treatment of severe diffuse acute respiratory distress syndrome in an intubated-ventilated patient which includes sedating said patient with at least one alpha-2 agonist, maintaining spontaneous ventilation and applying pressure support ventilation of at least 5-10 cmH2O combined to a high positive end expiratory pressure (PEEP) of 10-24 cmH2O. A pharmaceutical composition containing at least one alpha-2 agonist suitable for treatment of ARDS in combination with, if appropriate, at least one sedative agent which does not depress ventilatory drive is also disclosed.

The invention provides a formulated beverage composition that can be administered to a patient, prior to anesthesia, sedation and / or surgical or dental operation, to reduce the risk of aspiration pneumonia while simultaneously improving the well-being of the patient. The beverage composition is designed to be taken orally, by a patient, within a specified short period of time prior to administration of an anesthesia and / or sedative / analgesic. Further described herein is the method of using the beverage composition. The method may include providing a written label of instructions affixed to the beverage container which instructions positively direct the patient's ingestion of the beverage composition.

In one embodiment, prior to undergoing surgery, a patient is trained in the use of an anesthesia-awareness detection (AAD) system to produce an observable output by attempting to move a muscle. The AAD system includes an electromyographic (EMG) signal monitor. While undergoing surgery, the patient is anesthetized with a sedative and a paralytic. During surgery, if the surgical team wishes to asses the consciousness state or communicative ability of the patient, then the surgical team asks the patient to move the muscle. If the patient is unable to speak due to the paralytic but is aware and attempts to comply, then the attempt is detected by the AAD system, which provides a corresponding output to inform the surgical team, which may take appropriate action to ask additional questions of the patient and / or address the patient's anesthesia awareness.

Arylalkyl ketone piperazine derivatives of the formula: and pharmaceutical compositions comprising the same. Also dislcosed are methods for using the compounds as analgesic and sedative agents. The compounds of the present invention have good analgesic and sedative activities but few side effects.

A method for treatment of severe diffuse acute respiratory distress syndrome in an intubated-ventilated patient which includes sedating said patient with at least one alpha-2 agonist, maintaining spontaneous ventilation and applying pressure support ventilation of at least 5-10 cmH2O combined to a high positive end expiratory pressure (PEEP) of 10-24 cmH2O. A pharmaceutical composition containing at least one alpha-2 agonist suitable for treatment of ARDS in combination with, if appropriate, at least one sedative agent which does not depress ventilatory drive is also disclosed.

The present invention relates to the titration and delivery of anesthetic and sedative medications to a subject. Further, the present invention relates to a device and methods for titrating and delivering such medications in a semi-automated or fully automated manner and which can be monitoring and controlled remotely. Even still further, the present invention relates to such a device that can perform the titration and delivery of medication in a manner that minimalizes occlusion and prevents back flow of the medication. More particularly, the present invention relates to a device for titration and delivery of medication using a non-concentric pumping mechanism that gradual or progressively increases and decreases occlusion in the medication delivery line within the pump to minimize and / or prevent sudden formation and release of occlusion in order to provide more steady and continuous flow of the medication through the device to the subject.

Intended to prevent self-extubation of nasal or oral tubes of an awake patient who may reflexively attempt removal of such and allow the early mobilization and exercise necessary for preservation of as much muscle strength as possible, promotion of diaphragmatic motion necessary for liberation from a ventilator, reduction of patient stress allowing for sedation minimization and improved cognition for reduction of delirium and post-intensive care syndrome, and relief of medical staff and healthcare dollars to focus more on healthcare rather than on protection from self-harm.

The present disclosure relates to an improved process for the preparation of isochroman structured alpha2A adrenoceptor agonist, namely 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole of formula (I) and a pharmaceutically acceptable salts thereof, such as 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole hydrogensulfate of formula (Ia), and to a novel intermediate compound used in the process, namely N-(2-aminoethyl)-5-methoxyisochroman-1-carboxamide monohydrate of formula (V). Alpha2A agonists are useful in the treatment of anxiety, and for use as a sedative or analgesic agent, and other diseases where alpha2A agonism is desired.

Systems and methods are provided for monitoring the sedation level of patients. Images may be captured of a patient and regions of interest identified. Changes to image properties or to one or more regions of interest may be analyzed to generate physiological parameters for the patient. Physiological parameters may include information related to the patient's breathing behavior and / or activity. Physiological parameters may be used to determine a sedation level of the patient. If it is determined that the patient is over- or under-sedated, appropriate action may be taken, such as displaying an indication, activating an alarm, and / or causing an amount of sedative to be administered to the patient.

An external defibrillator system such as a WCD is also capable of providing transthoracic pacing and drug delivery (e.g., pain-reducing drugs and / or a sedatives) to a patient. The drug(s) may be included in the therapy electrode electrolyte and dispensed for defibrillation, cardioversion and / or pacing therapy. Alternatively, the drug(s) may be stored in a separate reservoir and dispensed during pacing therapy. The drug(s) may be dispensed to a patient after a successful defibrillation therapy. The pacing therapy may be delivered a set time-period after the drug(s) were dispensed. A relatively small electric current may be delivered to the area of the patient on which the drug(s) were dispensed to facilitate drug absorption.

A sedation device (1) has a housing (2) divided internally into a ventilator chamber (3) and an associated evaporator chamber (4) which overlap and are separated by a filter (5) mounted between the chambers (3, 4) and forming a common gas-permeable dividing wail between the chambers (3, 4), An inlet port (7) is provided at one end of the ventilator chamber (3) at a top of the housing (2) for connection to a patient ventilator in use. An outlet port (8) on the evaporator chamber (4) can be connected via a breathing tube to a patient. An evaporator (10) is mounted within the evaporator chamber (4) for delivery of a volatile sedative into the evaporator chamber (4) during use.

The present disclosure relates to an improved process for the preparation of isochroman structured alpha2A adrenoceptor agonist, namely 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole of formula (I) and a pharmaceutically acceptable salts thereof, such as 2-(5-methoxyisochroman-1-yl)-4,5-dihydro-1H-imidazole hydrogensulfate of formula (Ia), and to a novel intermediate compound used in the process, namely N-(2-aminoethyl)-5-methoxyisochroman-1-carboxamide monohydrate of formula (V). Alpha2A agonists are useful in the treatment of anxiety, and for use as a sedative or analgesic agent, and other diseases where alpha2A agonism is desired.

The invention provides a synthesis method of fospropofol sodium and intermediates thereof, the fospropofol sodium comprises an intermediate B and an intermediate C, the invention also provides application of the fospropofol sodium prepared by the synthesis method in an anesthetic sedative for animals. The synthesis method of fospropofol disodium avoids the use of a highly toxic reagent bromochloromethane, and has high safety; the prepared fosfopropofol intermediate is mild in reaction condition and simple and convenient to operate, the mass yield is greater than 97%, industrial production is easy, and a propofol prodrug prepared from fosfopropofol sodium synthesized by the synthesis method can generate the same clinical effect as that of a commercially available propofol emulsion injection, and the myocardial inhibition reaction caused by fospropofol anesthesia does not occur.

The present invention is drawn to a gas induction chamber that is particularly suited to being scaled to larger animals, such as swine. The present invention solves the problems associated with researchers having to physically restrain animals to inject them with sedative and / or holding a cone over the animal's face to introduce sedation. That process can be dangerous for both the researcher and the animal. The present invention provides a gas induction chamber for use with larger animals comprised of a combination of interconnecting frame members for use in connecting side panels, roof panels, and floor panels into a leak-free chamber. A gas inlet pipe is located near the top of the back side panel and an extraction pipe located near the bottom of the back side panel.

By intravenously administering a sedative comprising methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate or a salt thereof to a patient by a dosing regimen including a two-step process disclosed in the present invention, general anesthesia can be safely and promptly induced and maintained.

The invention relates to systems and methods for controlling the transdermal and automatic release of sedative during imaging of a subject. A sedation level of the patient is detected during the imaging procedure. An amount of a sedative to be applied to the patient to maintain a degree of sedation is calculated. Further, a time for releasing the amount of sedative is calculated. The calculated amount of sedative is percutaneously released to the patient at the calculated time.