The present invention generally relates to pharmaceutical compositions comprising a
dopamine agonist and
sedative agent. In a preferred embodiment, the
dopamine agonist is optically pure (S)-didesmethylsibutramine. In a preferred embodiment, the
sedative agent is optically pure (S)-
zopiclone or optically pure (S)-N-desmethylzopiclone. In a preferred embodiment, the
dopamine agonist is optically pure (S)-didesmethylsibutramine; and the
sedative agent is optically pure (S)-
zopiclone or optically pure (S)-N-desmethylzopiclone. The pharmaceutical compositions of the invention are useful in the treatment of restless-leg syndrome and periodic-limb-movement disorder, as well as various sleep disorders. In addition, the present invention relates to a method of treating a patient suffering from restless-leg syndrome, periodic-limb-movement disorder, a sleep
abnormality, or
insomnia, comprising coadministering a therapeutically effective amount of a
dopamine agonist and a therapeutically effective amount of a sedative agent. In a preferred embodiment, the
dopamine agonist is optically pure (S)-didesmethylsibutramine. In a preferred embodiment, the sedative agent is optically pure (S)-
zopiclone or optically pure (S)-N-desmethylzopiclone. In a preferred embodiment, the
dopamine agonist is optically pure (S)-didesmethylsibutramine; and the sedative agent is optically pure (S)-zopiclone or optically pure (S)-N-desmethylzopiclone.