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Application of dextro-oxiracetam in pharmaceutical field

A technology for a drug and a compound is applied in the application field of dexoxiracetam in the preparation of antiepileptic drugs, and can solve the problems of not having antiepileptic drugs and the like

Inactive Publication Date: 2016-11-30
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that oxiracetam is used as an adjuvant treatment for epilepsy patients, and for the treatment of cognitive and behavioral disorders after epilepsy. In essence, antiepileptic drugs inhibit the central nervous system, while dextran oxiracetam has an enhanced effect. The conduction of nerve excitement, promote the activity of the nervous system, enhance memory, improve learning ability, and improve forgetfulness. Oxiracetam does not have anti-epileptic effects

Method used

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  • Application of dextro-oxiracetam in pharmaceutical field
  • Application of dextro-oxiracetam in pharmaceutical field
  • Application of dextro-oxiracetam in pharmaceutical field

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0269] The prescription consists of:

[0270] (a) Dexoxiracetam (99.5% pure) 200mg / capsule

[0271] (b) Lactose 80mg / capsule

[0272] (c) Microcrystalline cellulose 70mg / capsule

[0273] Taking the preparation of 1000 dexoxiracetam capsules as an example, the specific preparation method is: first pass the raw and auxiliary materials through 80 sieves, weigh the prescribed amount of dexoxiracetam, lactose, and microcrystalline cellulose and mix them evenly. Fill capsules directly.

Embodiment 2

[0275] The prescription consists of:

[0276]

[0277] Taking the production of 1000 dexoxiracetam tablets as an example, the specific preparation method is: first pass the raw and auxiliary materials through an 80-mesh sieve, weigh the prescribed amount of dexoxiracetam, starch, and microcrystalline cellulose and mix them evenly , add 2% HPMC aqueous solution to make soft material, granulate, dry, granulate, add prescription amount of talcum powder to the granules, mix evenly, and compress into tablets.

Embodiment 3

[0279] The prescription consists of:

[0280]

[0281]Taking the production of 1000 dexoxiracetam capsules as an example, the specific preparation method is: first pass the raw and auxiliary materials through an 80-mesh sieve, weigh the prescribed amount of dexoxiracetam, lactose, and sodium carboxymethyl starch and mix them evenly , add 10% PVP ethanol solution to make soft material, granulate, dry, granulate, add prescription amount of talcum powder to the granule, mix evenly, and fill the capsule.

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Abstract

The invention provides application of dextro-oxiracetam in preparation of drugs for prevention or treatment of epilepsy. Experimental results show that dextro-oxiracetam has obvious treatment effect on generalized epilepsy seizure, partial epilepsy seizure and status epilepticus.

Description

technical field [0001] The invention relates to the medical use of Dexoxiracetam, in particular to the application of Dexoxiracetam in the preparation of antiepileptic drugs. Background technique [0002] Dextro-oxiracetam ((R)-4-hydroxyl-2-oxo-1-pyrrolidineacetamide) is the dextrorotatory form of oxiracetam (Oxiracetam CAS 62613-82-5), CN102603607A discloses its Preparation. Compared with mixed-oxiracetam and levo-oxiracetam, mixed-oxiracetam and levo-oxiracetam can enhance memory, improve learning ability, and improve cognitive dysfunction in patients, while dextro-oxiracetam Racetam is not effective for cognitive impairment. At present, there is no report on the application of Dexoxiracetam alone as a drug. [0003] People in the industry know that epilepsy is a common chronic neurological disease with repeated sudden seizures of loss of consciousness accompanied by convulsions as the main symptom. The seizures are usually directly caused by short-term abnormal synchro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4015A61P25/08
CPCA61K31/4015A61K9/0019A61K9/0053A61K47/26A61K9/08A61K9/2018A61K9/4858A61P25/08A61K2300/00
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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