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Application of levo-oxiracetam in preparation of medicine for treating memory and intelligence disturbance

A technology for mental retardation and memory, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, and can solve the problems of the difference and connection between the undisclosed pharmaceutical properties of the L- and D-forms of oxiracetam

Inactive Publication Date: 2014-02-26
NANJING YOUKE BIOLOGICAL MEDICAL RES +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report that levoxiracetam is used alone in the treatment of memory and mental disorder drugs caused by traumatic brain injury, and there has never been any prior art that discloses the effects of levoxiracetam and dexolaracetam. Racetam conducts comparative studies on pharmacology, pharmacodynamics and pharmacokinetics, etc., and does not disclose the difference and connection between the pharmaceutical properties of the L-form and D-form of Oxiracetam

Method used

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  • Application of levo-oxiracetam in preparation of medicine for treating memory and intelligence disturbance
  • Application of levo-oxiracetam in preparation of medicine for treating memory and intelligence disturbance
  • Application of levo-oxiracetam in preparation of medicine for treating memory and intelligence disturbance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] The prescription consists of

[0086] (a) Levo-oxiracetam (99.6% pure) 250mg / tablet

[0087] (b) Pregelatinized starch 30mg / tablet

[0088] (c) Microcrystalline cellulose 55mg / tablet

[0089] (d) Magnesium stearate 5mg / tablet

[0090] (e) Sodium carboxymethyl starch 5mg / tablet

[0091] Taking the production of 1000 levoxiracetam tablets as an example, the specific preparation method is: first pass the raw and auxiliary materials through a 100-mesh sieve, weigh the prescribed amount of levoxiracetam, pregelatinized starch and microcrystalline cellulose and mix Uniform, add 8% starch slurry to make soft material, granulate, dry, granulate, add prescription amount of magnesium stearate and sodium carboxymethyl starch to the granules, compress into tablets, use 8% Opadry 95% ethanol Solution coating.

Embodiment 2

[0093] The prescription consists of

[0094] (a) Levo-oxiracetam (99.5% pure) 250mg / capsule

[0095] (b) Lactose 70mg / capsule

[0096] (c) Sodium carboxymethyl starch 65mg / capsule

[0097] (d) Talc powder 6mg / granule

[0098] (e) 10% polyvinylpyrrolidone appropriate amount

[0099]Taking the preparation of 1000 levoxiracetam capsules as an example, the specific preparation method is: first the raw and auxiliary materials are passed through a 100-mesh sieve, and the levoxiracetam, lactose, and carboxymethyl starch sodium are mixed evenly by weighing the prescribed amount, Add 10% polyvinylpyrrolidone solution to make soft material, granulate, dry, granulate, add prescription amount of talcum powder to the granules, mix evenly, and fill the capsules.

Embodiment 3

[0101] The prescription consists of

[0102] (a) Levo-oxiracetam (purity: 99.6%) 250mg / bag

[0103] (b) Mannitol 150mg / bag

[0104] (c) Sucrose 100mg / bag

[0105] (d) Sodium carboxymethyl starch 20mg / bag

[0106] Taking the preparation of 1000 bags of levoxiracetam granules as an example, the specific preparation method is to pass the raw and auxiliary materials through a 100-mesh sieve, weigh the prescribed amount of levoxiracetam, mannitol, sucrose and sodium carboxymethyl starch and mix them evenly , add 8% starch to make soft material, granulate, dry, granulate, and pack.

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Abstract

The invention relates to new use of levo-oxiracetam in pharmaceutical field, and in particular relates to application of levo-oxiracetam in preparation of a medicine for treating memory and intelligence disturbance. The experiment result shows that the levo-oxiracetam is a main active ingredient for playing efficacy in oxiracetam, the clinical dosage can be greatly reduced by singly using the levo-oxiracetam, and the potential toxic and side effect is reduced. According to the invention, the levo-oxiracetam is a single active ingredient, the raw material purity is greater than 99.5% so as to effectively avoid the toxicity risk caused by other impurities in the medicine, the pharmacy is safer, the medicine quality is more controllable, and the curative effect is more precise.

Description

technical field [0001] The invention relates to a new medical application of levo-oxiracetam, in particular to the application of levo-oxiracetam in the preparation of medicines for treating memory and mental disorders caused by traumatic brain injuries. Background technique [0002] Oxiracetam is a new central nervous system drug that promotes learning and enhances memory. The active ingredient is a synthetic cyclic derivative of hydroxyaminobutyric acid (BABOB), which only acts on the central nervous system, and is mainly distributed in the cerebral cortex and hippocampus. It can activate, protect or promote the functional recovery of nerve cells, and improve mental retardation. The memory and learning function of the drug itself, while the drug itself has no direct vascular activity, nor does it have a central excitatory effect, and the effect on the learning and memory ability is a lasting promotion effect. Mechanism research results show that oxiracetam can promote the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4015A61P25/28
Inventor 张峰陈敏闵涛车晓明李上薛峪泉
Owner NANJING YOUKE BIOLOGICAL MEDICAL RES
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