182 results about "Male patient" patented technology

Therapeutic devices and methods according to embodiments of the invention alleviate e.g. urinary incontinence in female and male patients. Suction or vacuum, for example, is applied to the genital region, clitoris or clitoral region, the external urethral orifice, and / or other designated areas, e.g. physically stimulating the sacral / pudendal nerves and / or nerve roots and alleviating incontinence. Such embodiments also can encourage or cause clitoral engorgement, or otherwise promote blood flow in the genital region. Vacuum or suction applied to e.g. the clitoris creates a negative pressure in the clitoris that is lower than the systolic blood pressure, tending to promote engorgement of the clitoris with blood. Aspects of the invention are applicable not only to treatment of urinary and fecal incontinence, but also to the treatment of female sexual dysfunction. Aspects of the invention are also applicable to treatment of male incontinence and male erectile dysfunction.

Novel methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug. Embodiments are provided in which the involved prescribers, pharmacies and patients are registered in one or more computer databases. Embodiments are also provided in which registered patients receive counseling information concerning the risks attendant to foetal exposure to the drug. Male patients and female patients who are not pregnant may, in certain circumstances, receive the drug.

Therapeutic devices and methods according to embodiments of the invention alleviate e.g. urinary incontinence in female and male patients. Suction or vacuum, for example, is applied to the genital region, clitoris or clitoral region, the external urethral orifice, and / or other designated areas, e.g. physically stimulating the sacral / pudendal nerves and / or nerve roots and alleviating incontinence. Such embodiments also can encourage or cause clitoral engorgement, or otherwise promote blood flow in the genital region. Vacuum or suction applied to e.g. the clitoris creates a negative pressure in the clitoris that is lower than the systolic blood pressure, tending to promote engorgement of the clitoris with blood. Aspects of the invention are applicable not only to treatment of urinary and fecal incontinence, but also to the treatment of female sexual dysfunction. Aspects of the invention are also applicable to treatment of male incontinence and male erectile dysfunction.

A male sexual impotence treatment apparatus includes an elongate adjustable constriction member extending in a loop around a male patient's penile tissue or the prolongation thereof. An adjustment device adjusts the longitudinal extension of the constriction member in the loop to temporarily constrict the penile tissue or the prolongation thereof to restrict the penile exit blood flow to achieve erection. A layer of a soft viscoelastic material is applied on the constriction member such that it is located between the constriction member and the patient's penile tissue or the prolongation thereof at least along a portion of the constriction member to protect the penile tissue or the prolongation thereof from being eroded by the constriction member. The layer has an inwardly directed radial extension in the loop such that, when the adjustment device is operated to decrease the longitudinal extension of the constriction member in the loop, the soft layer is forced to expand radially inwardly in the loop causing a corresponding increased constriction of the penile tissue or the prolongation thereof.

A device for occluding a body lumen, and particularly contraceptive or sterilization device for occluding a reproductive tract or lumen to prevent the passage of reproductive cells through the tract or lumen, generally comprising a tubular member, and a mesh member, transversely disposed on the tubular member lumen. The mesh member is permeable to allow for tissue ingrowth, which produces a tissue impregnated mesh occluding the body lumen. The occluding device of the invention can be used in the fallopian tubes of a female patient, the vas deferens of a male patient, or other body lumen.

A male sexual impotence treatment apparatus comprises a constriction device implanted in an impotent male patient and engaging the patient's penile tissue. The constriction device includes an elongate adjustable constriction member extending in a loop around the penile tissue or the prolongation thereof. A connection device releasably connects the end portions of the constriction member to each other and an adjustment device adjusts the longitudinal extension of the constriction member in the loop to temporarily constrict the penile tissue or the prolongation thereof to restrict the penile exit blood flow to achieve erection. The connection device includes a female part and a male part fitting into the female part to lock them together. The design of the connection device facilitates laparoscopic surgery for implanting the constriction member.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and / or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive impairment, decreased libido, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

A less invasive disposable urinary collection device for receiving a penis of a male patient comprises a freestanding bulb-shaped sack formed from a single sheet of laminate material. The sheet includes a first absorbent inner layer disposed between a moisture impervious outer layer and a second absorbent layer. The sack has a top hand insertion opening with elastic and an elastic passageway disposed orthogonal to the hand opening for securing the sack to the penis.

Systems and methods of localizing or delivery cells, biologics and / or drugs to a specific target area to treat pelvic health disorders are provided. A treatment composition including cells, biologics and / or drugs are associated with magnetic particulates, and the positioning of these materials is facilitated through use of a magnetic field-generating device that is configured to be placed on or into a pelvic anatomical structure. Certain embodiments directed to the treatment of ED in male patients can include a cell based therapy system.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and / or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Compounds of structural formula (I) are disclosed as useful for modulating the androgen receptor (AR) in a tissue selective manner in a patient in need of such modulation, and in particular for antagonizing AR in the prostate of a male patient or in the uterus of a female patient and agonizing AR in bone and / or muscle tissue. These compounds are useful in the treating conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including: osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, female sexual dysfunction, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, prostate cancer, arthritis and joint repair, alone or in combination with other active agents. In addition, these compounds are useful as pharmaceutical composition ingredients alone and in combination with other active agents.

A disposable urinary collection device for receiving a penis of a male patient comprises a bulb-shaped sac formed from a single sheet of material. The sheet has edges drawn together by a first elastic member to form a gathered hand insertion opening. The bulb-shaped sac has a passageway extending through a side thereof for receiving the penis. An outer perimeter of the passageway has a second elastic member for securing the sac to the penis.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and / or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

An apparatus for providing a vibratory stimulus to the penis of a male human comprising a cuff adapted to fit around the penis, which cuff includes one or more vibratory means operable at a pre-determined or variable frequency. A method of measuring premature ejaculation in a male human, said method comprising the steps of : a) positioning a vibratable cuff to the penis of the human; b) providing a vibratory stimulus having either a pre-determined constant frequency or a variable frequency to induce ejaculation; c) measuring the latency time period to ejaculation at said vibratory stimulus and / or the threshold frequency required to induce ejaculation; and d) comparing said latency measurement and / or said threshold frequency to known standard measurements. A method of evaluating a novel potential therapeutic agent for the treatment of premature ejaculation in a male patient. Initial assessment of premature ejaculation can be made as a baseline measurement, and then novel potential therapeutic agents administered to the patients.

This document provides methods and materials related to assessing prostate cancer in mammals. For example, methods and materials for using ERG expression levels and TOP2A expression levels to identify mammals (e.g., male human patients) as being susceptible to a poor prostate cancer outcome are provided.

A method for sterilizing a female or male patient is provided. The method comprises introducing into a reproductive duct of the patient a composition comprising a nucleophilic component, such as a thiol, and a component containing a conjugated unsaturated bond, such as an acrylate. The composition crosslinks within the reproductive duct. Within a female patient, the composition is introduced into one or both uterine tubes. The composition gels in the uterine tubes, thereby blocking the uterine tubes and preventing conception.

An article of clothing incorporated with a urine drainage device according to the present invention primarily comprises: a clothing article having an opening at the front region sheet positioned corresponding to a wearer's urinary organ, a foundation settled about said opening having a round hole, a foundation with a round hole disposed in the opening, a drainage device which consists of a urinary-organ sleeve and a conduit wherein the urinary-organ sleeve has a joint at its one end detachablely attached to said foundation and the conduit may be extend to a urine receptacle. When a male patient wears the disclosed subject matter, his urinary organ may be accommodated in the urinary-organ sleeve so that the emitted urine can be led to the conduit through the conical funnel and then be collected in the mentioned urine receptacle.

Provided is a method for determining the prognosis of cancer in a female patient with a solid tumor. Also provided is a method of sensitizing a cancer cell from a solid tumor from a male patient other than a prostate cancer cell to treatment with a chemotherapeutic agent comprising administering an effective amount of(a)(i) at least one antiandrogen;(ii) at least one inhibitor of androgen synthesis; or(iii) a combination of at least one antiandrogen and at least one inhibitor of androgen synthesis; and(b) at least one chemotherapeutic agent other than an antiandrogen or an inhibitor of androgen synthesis for the treatment of cancer characterized by a solid tumor, other than prostate cancer, in a male patient. The antiandrogen, the inhibitor of androgen synthesis, or the combination of both may be administered before, after, or at the same time as the chemotherapeutic agent.

Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and / or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, arthritic condition and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer s disease, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

The invention discloses a bladder pressure and / or urethra pressure measuring tube fixer comprising two bonding rubberized fabrics, wherein the two bonding rubberized fabrics are respectively connected with a clamp body by a rope belt with width of 1-2mm and length of 1-2cm, resistance arms of two articulated arms of the clamp body have corresponding arc-shaped structures, the end part of a power arm of one articulated arm has an arc tooth structure, a power arm of the other articulated arm has a turn arm structure, one surface of the turn arm opposite to the arc toothis provided with an engaging tooth, and the two articulated arms of the fixer are used for fixing a pressure measuring tube and are symmetrically fixed on both sides of the penis of a male patient or two inner thigh sides or both sides of the perineum of a female patient by the two rubberized fabrics. The bladder pressure and / or urethra pressure measuring tube fixer can be used for conveniently and firmly fixing the bladder and the urethra pressure measuring tube in bladder function clinical measurement, thereby ensuring that clinical bladder urethra pressure and / or bladder pressure-a urinary flow rate can be normally measured in clinic. The fixer also can be used for fixing a per urethra indwelling catheter and is especially suitable for fixing a catheter without an air bag.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and / or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer s disease, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

A simple surgical drape system of generally flat shape for male urology procedures that provides full isolation of top versus bottom surface by a sealing fenestration surrounding the meatus area. It is achieved by manually forming the flat drape to a tent-like shape around the penis with a fenestration aperture smaller than glans diameter, supported by and sealing to the glans tip, and then attaching a penile clamp to hold the drape. This allows a simplified safer antibacterial preparation and less chance of infection complications. The sealed design permits better management of urology liquids, and can use absorption pad on drape top side. The drape wrinkles act as a penile position stabilizer, reducing need for extended use of the one operator hand for penile support. Drape is removable with catheter in place.

The invention discloses a trace seminal fluid collecting, storing and freezing device for solving the difficult problem of freezing storage of trace seminal fluid obtained after a male patient with azoospermia or oligospermia is treated in an operation and a lab. The device comprises a seminal fluid collecting and storing tube and a sealing tube used for sealing the seminal fluid collecting and storing tube, wherein the seminal fluid collecting and storing tube comprises a capillary tube section used for sucking seminal fluid and a handheld tube section connected with the capillary tube section. According to the device, the trace seminal fluid is sucked by utilizing the capillarity phenomenon principle of the capillarity tube section and stored in the capillarity tube section, so that the trace seminal fluid is collected and stored; the seminal fluid collecting and storing tube is sealed with the sealing tube, so that the seminal fluid can be prevented from being polluted and lost; and the device is put in liquid nitrogen for freezing the seminal fluid, so that the trace seminal fluid is frozen for storage.

The invention relates to an urination tool for male, particularly to a clamp-type external catheter for male. The clamp-type external catheter for male comprises a penis clamping device, a ring-shaped holder, a ring-shaped urine tube connecting device, a soft protective jacket and a light and thin soft tube. By the use of the clamp-type external catheter for male, pain and infection of users caused by urination with intervening type tubes can be avoided as far as possible, and the discomfort for users and inconvenient operation or pollution caused by urination with plastic bags tying penis or urination with urinals can be avoided, urination is smooth and leak free, and thereby the anxiety and worry of users for urination lying in bed can be released, working intensity of nurses can be decreased and life quality of patients can be increased. Urination is convenient for users lying in bed, particularly convenient for urination incontinent male patients. The clamp-type external catheter for male belongs to the field of human daily necessities.

Compounds of structural formula I as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of activating the function of the androgen receptor in a patient, and in particular the method wherein the function of the androgen receptor is blocked in the prostate of a male patient or in the uterus of a female patient and activated in bone and / or muscle tissue. These compounds are useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporesis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, female sexual dysfunction, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, prostate cancer, arthritis and joint repair, alone or in combination with other active agents.

In a male external urinary catheter comprising a cylindrical discharge tube connected to a funnel through a bulbous zone wherein the extreme edge of the funnel is fitted with a rolled up coverette of latex rubber, polyurethane or the like that can be unfurled to encapsulate the patient's male organ, a unitary strap is provided having an connecting end unitary attached to said coverette and formed of a like material therewith and having intermediate and free end regions adapted to be looped about the coverette back upon themselves, the unitary strap including a fastener for attaching the strap upon itself without contacting the skin of a male patient.

The present invention provides stable pharmaceutical compositions, comprising a pharmaceutically effective amount of testosterone or a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable oil vehicle, and a stabilizing amount of benzyl alcohol, for example, about 1% to 3% weight / volume of benzyl alcohol. The present invention also provides a process for stabilizing testosterone-containing pharmaceutical compositions by ageing them at a temperature of about 20° C. to about 60° C. for at least 48 hours, e.g., prior to secondary packing and labeling. These compositions were stable over the shelf life of the product, without exhibiting crystal formation, even upon storing at temperatures of about 2° C. to about 8° C. Other aspects of the invention relate to methods for making such pharmaceutical compositions, and methods of using such pharmaceutical compositions for hormone replacement therapy, e.g., in a male patient having a condition associated with symptoms of deficiency or absence of endogenous testosterone.

The invention relates to a nonintrusive type urinary catheterization device for males, comprising a clamping ring, an upper semicircular elastic round pipe ring, a lower semicircular elastic round pipe ring, a silicon rubber sealing ring and a urine buffer cavity ball which are mutually connected, wherein a closed ring and a half round-pipe-shaped clamping ring are integrated at one end of the clamping ring, and two symmetrical semicircular-pipe-shaped clamping rings become a round-pipe-shaped clamping ring at the other end of the clamping ring after the two symmetrical semicircular-pipe-shaped clamping rings are closed. The nonintrusive type urinary catheterization device is convenient to urinate for male patients who lie in bed, especially for the male patients who are operated, fractured, disabled or lie or the male old people who lie in bed for long terms, and belongs to the field of human necessities.