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Mesoporous titanium dioxide and preparation method thereof and application thereof

A kind of mesoporous titanium dioxide, uniform technology, applied in the field of medicine, to achieve the effect of good chemical stability and physiological compatibility, low density, high specific surface area

Inactive Publication Date: 2012-10-10
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a poorly soluble drug carrier, there are no relevant reports on improving the dissolution rate and bioavailability of poorly soluble drugs. The research on mesoporous titanium dioxide as a drug carrier has far-reaching significance for the development of new drug excipients

Method used

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  • Mesoporous titanium dioxide and preparation method thereof and application thereof
  • Mesoporous titanium dioxide and preparation method thereof and application thereof
  • Mesoporous titanium dioxide and preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Accurately take 15.8g of F127 and add it to 400ml of absolute ethanol to dissolve it completely, add 9.25ml of isopropyl titanate and 3.2ml of double distilled water, keep stirring at room temperature for 40min and then stand still for 24h, centrifuge to collect the precipitate, and remove the precipitate Add an appropriate amount of absolute ethanol to the centrifuge tube, stir gently, collect the precipitate by centrifugation, repeat 3 times, dry the precipitate in a 50°C oven for 24 hours, put the dried sample in a conical flask, add 200ml of absolute ethanol , stirred in a water bath at 70°C for 2 hours, centrifuged to collect the precipitate, put the precipitate into the Erlenmeyer flask, repeated the above operation for a total of 3 times, dried the precipitate in a 50°C oven for 24 hours, and put the dried sample into the Erlenmeyer flask After cleaning, the precipitate was dried in an oven at 50°C for 24 hours, and the surfactant F127 was removed by repeated wash...

Embodiment 2

[0038] Accurately take 9.25ml of isopropyl titanate and 1.6ml of potassium chloride solution and add it to 400ml of absolute ethanol, keep stirring at room temperature for 40min and then stand still for 24h, centrifuge to collect the precipitate, put the precipitate into a centrifuge tube and add an appropriate amount of no Gently stir after water and ethanol, centrifuge to collect the precipitate, repeat 3 times, dry the precipitate in an oven at 50°C for 24 hours, and obtain mesoporous spherical titanium dioxide after drying.

Embodiment 3

[0040] Accurately take 15.8g of F127 and add it to 400ml of absolute ethanol to dissolve it completely, add 9.25ml of isopropyl titanate and 3.2ml of double distilled water, keep stirring at room temperature for 40min and then stand still for 24h, centrifuge to collect the precipitate, and remove the precipitate Add an appropriate amount of absolute ethanol to the centrifuge tube, stir gently, collect the precipitate by centrifugation, repeat 3 times, and finally dry the precipitate in a 50°C oven for 24 hours, and calcinate the dried sample at 400°C for 4 hours to remove surface activity. Agent F127 to obtain spherical mesoporous titania.

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Abstract

The invention belongs to the field of medicine technology, and relates to a preparation method of mesoporous titanium dioxide with high biological compatibility and a controllable structure and application of the mesoporous titanium dioxide as a hard soluble drug carrier. The method adopts a soft template method, namely, adopts a surfactant as a structure guiding agent, isopropyl titanate as titanium source, and double distilled water as a reaction rate modifier to prepare the mesoporous titanium dioxide having different mesoporous passage structures. The prepared mesoporous titanium dioxide is of large specific surface area, chemical stability, non-toxic effect, no side effect and good biocompatibility, and is suitable for being used as the hard soluble drug carrier. The application of the titanium dioxide as the hard soluble drug carrier can lay a theoretical foundation for uses of multivariant functional carriers. The method adopts a solvent method and a fusion method to perform embedding and adsorption on a drug so as to uniformly disperse the drug inside the mesoporous or on surface of the carrier. The drug carrier system can assist in significantly enhancing water solubility of a hard soluble drug and improving dissolution rate in vitro and oral bioavailability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a mesoporous titanium dioxide with high biocompatibility and controllable structure, a preparation method and its application as an insoluble drug carrier. Background technique [0002] Oral preparations are easily accepted and adopted by patients due to their strong compliance, safety, and convenience, and are currently the preferred route of administration for most drugs. However, more than 1 / 3 of the drugs in the United States Pharmacopoeia, which contains the most drugs, are poorly water-soluble drugs; at the same time, about 40% of the drugs are poorly water-soluble drugs in the research of innovative drugs. Difficulty in drug dissolution greatly affects its oral bioavailability. Especially for Class II drugs in the classification of biopharmaceuticals, that is, drugs that are difficult to dissolve and absorb easily, the dissolution rate during oral application becomes the m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G23/053C01G23/08B82Y40/00A61K47/02
Inventor 王思玲姜同英姜海涛
Owner SHENYANG PHARMA UNIVERSITY
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