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226 results about "Monosaccharide composition" patented technology
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Monosaccharides are the simplest unit of carbohydrates. They're composed of carbon, hydrogen, and oxygen atoms, and they cannot be broken down further since they are already in their simplest form. Their general formula is (CH2O)n, where n is any number equal or greater than 3.
Treatments using transgenic goat produced antithrombin III
InactiveUS7019193B2Improve clearance ratePeptide/protein ingredientsHydrolasesPlasma derivedMonosaccharide composition
This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition which comprises N-acetylgalactosamine (GalNAc) along with fucose, N-acetylglucosamine, galactose, mannose, and N-acetylneuraminic acid / N-glycolyneuraminic acid. The monosaccharide composition differs with that of plasma derived ATIII (phATIII). It has been found that tgATIII has an increased clearance rate when compared to phATIII.
Owner:GTC BIOTHERAPEUTICS INC
Oligomerization pineapple ginseng glycosaminoglycan and preparation method thereof
ActiveCN101724086AGood anticoagulant and antithrombotic activityOrganic active ingredientsBlood disorderMonosaccharide compositionEnzyme inhibitor
Owner:SHENZHEN NEPTUNUS PHARM CO LTD
Low molecular weight carboxyl-reduced derivatives of fucosylated glycosaminoglycans and preparation method and applications of low molecular weight carboxyl-reduced derivatives
The invention discloses low molecular weight carboxyl-reduced derivatives of fucosylated glycosaminoglycans (LCRG). The extent of carboxyl reduction is not less than 20%. Weight-average molecular weight of the LCRG is about 3000-20000Da, and monosaccharides comprise acetyl galactosamine (GalNAc), glucose (Glc) or glucuronic acid (GlcUA) and fucose (Fuc) or sulfates of fucose (shown as -OSO3-). The mole ratio of GalNAc, Glc (containing GlcUA), Fuc and -OSO3- is about 1: (1+-0.3): (1+-0.3): (3.0+-1.0). The LCRG is a potent human immunodeficiency virus (HIV) Type 1 entry inhibitor which acts on conserved regions and has the advantages of high activity against HIV Type 1, high therapeutic index and no-drug-resistance, and the LCRG can be used for preventing or curing HIV. The invention further provides a preparation method of the LCRG. The carboxyl-reduced derivatives of fucosylated glycosaminoglycans and medicinal compositions of the carboxyl-reduced derivatives can be prepared into injection agents, lyophilized powder or suppository and the like.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI +1
Active composition for adjusting microorganism ecological balance of skin surface
InactiveCN106361684AAvoid stickingInhibition releaseAntibacterial agentsCosmetic preparationsMicroorganismLactobacillus
The invention discloses an active composition for adjusting microorganism ecological balance of a skin surface, and aims to provide an active composition capable of effectively promoting growth and reproduction of beneficial bacteria, inhibiting multiplication of harmful bacteria and adjusting microorganism ecological balance of the skin surface. The composition comprises, by weight, 3-15 parts of fructo-oligosaccharide, 5-12 parts of monosaccharide compositions, 1-8 parts of lactobacillus / soybean milk fermentation product filtrate and 30-50 parts of polyhydric alcohols. The invention belongs to the technical field of biology.
Owner:GUANGDONG BAWEI BIOLOGICAL TECH CO LTD
Novel cellular glycan compositions
InactiveUS20090317834A1Biological material analysisEmbryonic cellsMonosaccharide compositionMass spectrometric
The invention describes novel compositions of glycans, glycomes, from human embryonic stem cells, and especially novel subcompositions of the glycomes with specific monosaccharide compositions and glycan structures. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore, the invention is directed to stem cells carrying the modified glycomes on their surfaces. The glycomes are preferably analysed by profiling methods able to detect reproducibly and quantitatively numerous individual glycan structures at the same time. The most preferred type of the profile is a mass spectrometric profile. The invention specifically revealed novel target structures and is especially directed to the development of reagents recognizing the structures.
Owner:GLYKOS FINLAND
Low molecular weight glycosylated chondroitin sulfate and its purpose in preparation of anti-HIV-1 medicament
InactiveCN102247401AAvoid drug resistanceDepolymerization speed is stableOrganic active ingredientsAntiviralsMonosaccharide compositionUltrafiltration
The invention discloses a low molecular weight glycosylated chondroitin sulfate, whose weight average molecular weight is 3000-15000Da. The monosaccharide composition comprises acetyl galactosamine (D-GalNAc), glucuronic acid (D-GlcUA), fucose (L-Fuc), or its sulfuric ester (expressed in -OS03<->), wherein the mole ratio of D-GalNAc to D-GlcUA to L-Fuc to -OS03<-> is 1: (1+ / -0.3): (1+ / -0.3): (3.5+ / -0.5). The low molecular weight glycosylated chondroitin sulfate has a strong anti-HIV-1 virus activity, is a gp120 entry inhibitor, and can be used for preventing and / or treating AIDS. The invention also provides a method for preparing the low molecular weight glycosylated chondroitin sulfate and its composition preparation. Glycosylated chondroitin sulfate is depolymerized by the peroxide method to obtain a low molecular weight product, and then low molecular and / or high-molecular impurities of the product are removed by gel separation or ultrafiltration method. The low molecular weight glycosylated chondroitin sulfate and its medicinal composition can be prepared in the form of an injection, a lyophilized powder or a suppository.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI +1
Chinese magnoliavine fruit polysaccharide extract and preparation method and application thereof
InactiveCN102805762ASignificant antiallergic activityObvious superiorityCosmetic preparationsToilet preparationsMast cell degranulation testLactose
The invention discloses a Chinese magnoliavine fruit polysaccharide extract and a preparation method and an application thereof. Counted by D-glucose, the content of polysaccharides is not lower than 45 percent of the total weight of the polysaccharide extract; a monosaccharide mainly comprises D-glucose, D-galactose and D-galacturonic acid; the mass ratio of the D-glucose to the D-galactose is (3-9):1; and the D-galacturonic acid accounts for 5-40 percent of the total weight of the polysaccharide extract. As proved by mouse ear heterogeneous driven dermal sensitivity test and rat peritoneal mast cell degranulation test, the Chinese magnoliavine fruit polysaccharide extract has remarkable anti-allergic action activity, and can be used for preparing anti-allergic action medicaments, functional foods and cosmetics.
Owner:SHANGHAI HUATUO MEDICAL SCI CO LTD
Spirulina polysaccharide and application thereof
ActiveCN105707072AInduced plant disease resistanceNatural sourceBiocideAlgae medical ingredientsMonosaccharide compositionFreeze-drying
The invention relates to glucose-rich spirulina polysaccharide and an application thereof in a plant green pesticide and an anti-tumor drug. High-sugar spirulina obtained through nutritional regulation is used as a raw material and is subjected to hot water extraction, protein removal with a flocculant, concentration, precipitation and freeze drying to obtain the water-soluble high-sugar spirulina polysaccharide having the molecular weight of 10-200 kDa; the spirulina polysaccharide comprises the monosaccharides mainly comprising rhamnose, fucose, arabinose, xylose, mannose, galactose, glucose, glucuronic acid and galacturonic acid, and is characterized in that the glucose content is more than 50% in the monosaccharide composition. The spirulina polysaccharide can obviously induce plant disease resistance, has obvious anti-tumor effect on tumor, and can be used as the biological pesticide and the anti-tumor drug.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Sophora fungus mycoplasma extract identification and detection method
ActiveCN102621260AControl contentRaise quality standardsComponent separationMonosaccharide compositionAnion-exchange chromatography
The invention relates to a sophora fungus mycoplasma extract identification and detection method. The identification method is characterized in that an anion exchange chromatography method is used for establishing chromatographic fingerprint composed by monosaccharide of proteoglycan protein in the sophora fungus mycoplasma extract, and the quality is controlled by comparing the similarity of a sample fingerprint spectrum and a fingerprint spectrum of a standard extract. The detection method is characterized in that the anion exchange chromatography method is used for detecting the monosaccharide composition and content of proteoglycan protein of the sophora fungus mycoplasma extract, thereby the content limit can be made. The fingerprint spectrum of the anion exchange chromatography method combines the content determination method to realize the effective control of quality of the sophora fungus mycoplasma extract and the relative products as well as distinguish with other products. The method of the invention has the advantages of rapidity, convenience and strong specificity.
Owner:QIDONG GAITIANLI MEDICINES
Low-molecular weight schisandra chinensis polysaccharides and preparation method and application thereof
InactiveCN102757510AImprove autoimmunityHigh activityOrganic active ingredientsAntineoplastic agentsMonosaccharide compositionImmunocompetence
The invention discloses low-molecular weight schisandra chinensis polysaccharides and a preparation method and an application thereof, and belongs to the technical field of medicine. The molecular weight of the polysaccharide component is 3.4*10<3> Da, and the monosaccharide composition is as follows: mannose:glucose:galactose=1:11.38:3.55; and the polysaccharide component contains (1-3)-alpha-glucan and has a tri-helix structure. The study of in vivo activity against liver cancer of SCPP11 polysaccharide component shows that the polysaccharide component is significantly active against liver cancer (HepG-2), can significantly inhibit growth of liver cancer, and can significantly enhance the autoimmunity and in vivo antioxidant activity of mice as compared with the 5-Fu. The water-soluble low-molecular weight schisandra chinensis polysaccharides have the advantages of definite active components and controllable quality, and can be used as a drug against liver cancer or a health-care product for improving immunity.
Owner:JIANGSU UNIV
Method for identifying cordyceps sinensis products and uses thereof
The present invention provides a cordyceps product verifying method and application. The analysis on amylase and monosaccharose composition of different cordyceps products shows great difference; thereby verifying the types of cordyceps by analyzing the amylase and monosaccharose constitutes of cordyceps products. The present invention is suitable for natural cordyceps, artificial fermentation cordyceps and artificial fake cordyceps. As for a certain cordyceps product, the analysis of the amylase and monosaccharose composition is carried on the samples from the different batch produced or different production regions, and the result shows no remarkable difference, therefore, the method provided by the present invention can be used to verify batch stability of cordyceps products to control the quality of products.
Owner:柯传奎 +1
Rapid quantitative method for tea polysaccharide monosaccharide composition
InactiveCN105136951AEasy to separateMonosaccharide peaks are sharpComponent separationMonosaccharide compositionFiller Excipient
The invention discloses a rapid quantitative method for tea polysaccharide monosaccharide composition. The steps includes: (1) hydrolyzing tea polysaccharide with trifluoroacetic acid; (2) dissolving the hydrolyzed tea polysaccharid sample with ultra pure water to obtain a hydrolyzed polysaccharide solution, and adding trehalose to serve as the internal standard substance; (3) conducting derivatization on the internal standard containing hydrolyzed polysaccharide solution with 1-phenyl-3-methyl-5-pyrazolone (PMP); (4) at the same time of hydrolyzed polysaccharide derivatization, conducting derivatization on standard monosaccharide; and (5) carrying out high performance liquid chromatographic analysis, thus obtaining the content of each monosaccharide. The high performance liquid detection system conditions employed by the method include: octadecyl silane bonded silica gel is a chromatographic column of filler, the mobile phase is a buffer solution mixed according to certain ratio and an organic agent, the flow speed is 1.0ml / min, and the detection wavelength of an ultraviolet detector is 250nm. The method is simple, fast, convenient and, stable, achieves separation and analysis of monosaccharide within 20min, and improves the accuracy and precision of tea polysaccharide monosaccharide detection.
Owner:HUAZHONG AGRI UNIV
Method for high-yield production of oat polysaccharide with naked oat bran as raw material
The invention relates to a method for high-yield production of oat polysaccharide with naked oat bran as a raw material, which adopts the naked oat bran as a raw material and comprises the following steps: super-micro pulverization, ethanol pre-treatment, extraction for a plurality of times with water as extraction solvent, mixing of extracts, addition of enzyme degradation starch, isoelectric point deproteinization or deproteinization through hydrolysis with proteolytic enzyme, vacuum concentration, ethanol precipitation, static keeping, filtration, sediment collection and freeze drying or hot air drying, thereby obtaining the oat polysaccharide. The extraction rate of the oat polysaccharide in the invention is higher than 12g of oat polysaccharide per 100g of naked oat bran, the monosaccharide components of the oat polysaccharide comprise xylose and glucose, and the ratio of (1-3) glucosidic bonds and (1-4) glucosidic bonds is 1:1.3-1.3:1.
Owner:TIANJIN UNIV OF SCI & TECH
Trichoderma pseudokoningii exocellular polysaccharide, preparation method and application thereof
InactiveCN101220101AImprove immune activityEnhance phagocytic activityOrganic active ingredientsMicroorganism based processesMethod testMonosaccharide composition
The invention discloses a polysaccharide from Trichoderma pseudokoningii, which is characterized in that (1) the high performance gel filtration chromatography test shows that the polysaccharide has a symmetrical peak with 18325 molecular weight; (2) an improved sulfuric acid-phenol method and a 3-aminophenol method test show that the neutral polysaccharide content is 65.2 percent, while the uronic acid content is 32.6 percent; (3) the GC analysis of the alditol acetate shows that the monosaccharide components are rhamnose, glucose and galactose, the molar ratio is Rha:Glc:Gal relates to 5.6:2.7:1.0, while when the polysaccharide is completely reduced, the molar ratio is Rha:Glc:Gal relates to 14.5:9.3: 1.0, having 26.6 molar percent glucuronic acid. The preparation method of the polysaccharide from Trichoderma pseudokoningii consists of the crude polysaccharide preparation and the polysaccharide purification. The polysaccharide from the Trichoderma pseudokoningii has broad applications in preparing the drugs or functional food for improving the mammal immunocompetence and for treating or adjuvant treating the tumors.
Owner:SHANDONG UNIV
Antioxidant with function of inhibiting melanin production as well as preparation method and use of antioxidant
InactiveCN108309825AGood ability to scavenge free radicals in vitroSuppress generationCosmetic preparationsToilet preparationsKojic acidMonosaccharide composition
The invention discloses an antioxidant with a function of inhibiting melanin production as well as a preparation method and use of the antioxidant. The antioxidant is a polysaccharide component FMP separated out from morchella esculenta, and has a molecular weight of 4.5kDa; the monosaccharide composition mainly is prepared from mannose, glucose and galactose. The polysaccharide component FMP obtained by the method has good in-vitro free radical scavenging ability; in vitro and in vivo experiments prove that the polysaccharide component FMP can inhibit the melanin production and tyrosinase activity well, and does not have obvious toxic and side effects; the tyrosinase inhibition activity of the polysaccharide component FMP is comparable to that of kojic acid; therefore, the polysaccharidecomponent FMP can be used as a natural high-efficiency antioxidant and a melanin production inhibitor, and has a great application prospect in the fields such as food and cosmetics.
Owner:ANHUI UNIVERSITY
Grifola frondosa polysaccharide ZZK component and preparation method thereof
The invention relates to a Grifola frondosa polysaccharide ZZK component and a preparation method thereof. The fruit body in Grifola frondosa is used as the raw material and is subjected to drying, crushing, extraction, purification and other processes, thus being separated into a beta glucomannan (ZZK). The beta glucomannan (ZZK) comprises the main monosaccharides of glucose and mannitose, has a weight-average molecular weight of 380-750 thousand Daltons and has remarkable antineoplastic activity.
Owner:HANGZHOU ZHONGZHI KANGGU BIOLOGICAL TECH
Bacillus amyloliquefaciens and preparation method of exopolysaccharides thereof
ActiveCN106520641ANon-irritatingAntigenicBacteriaMicroorganism based processesChromatographic separationBacillus amyloliquefaciens
The invention provides bacillus amyloliquefaciens EZ99. The bacillus amyloliquefaciens is gram positive bacteria, exists in plant rhizosphere soil, has no pathogenicity for people and plants, is collected from an orchard county, in the west of a Qilihe district in the Lanzhou city of the Gansu province, and has been identified, registered and preserved in the China common microorganism strain preservation center, and the preservation number is CGMCC No.13267. Component analysis is performed on bacterial colonies formed by the bacillus amyloliquefaciens on a PMA and MS culture medium, and it is found that the bacillus amyloliquefaciens has the characteristic of synthesizing and secreting exopolysaccharides. Optimal culture medium formulas and fermentation optimal conditions based on fermentation production of the exopolysaccharides of the strains are built, a fermentation solution is subjected to centrifuging, alcohol precipitation, dialysis and chromatographic separation, four purification polysaccharide components are obtained, and four-polysaccharide-component monosaccharide composition and monomer molecular weight are determined. The exopolysaccharides obtained through the strain and the method have the various applications of medicines, cosmetics, food additives, biological film raw materials and the like.
Owner:甘肃尚农生物科技有限公司
Method for preparing flaxseed gum oligosaccharides by hydrogen peroxide oxidation degradation technology
InactiveCN106977616AEfficient cuttingEffective separation and purificationFood ingredient as antioxidantSugar derivativesMonosaccharide compositionUltrafiltration
The invention discloses a method for preparing flaxseed gum oligosaccharides by a hydrogen peroxide oxidation degradation technology. The flaxseed gum oligosaccharides (FGOSs) are prepared from commercial flaxseed gum by adopting a high pressure assisted hydrogen peroxide oxidation degradation technology through dynamic dissolving, oxidative degradation, suction filtering, decolorizing, ultrafiltration, dialysis, concentration and freeze-drying. The FGOSs obtained in the invention are a semisolid viscous substance, have a light reddish brown color and special fragrance, can be easily dissolved in water, are insoluble in ethanol and other organic solvents, can easily absorb moisture, are a typical carbohydrate substance, and contain uronic acid; the FGOSs have uniform components, the average molecular weight is 1047 Da, the FGOS have a pyranose ring structure, belong to pyranose, and are composed of the following seven monosaccharides: rhamnose, fucose, arabinose, xylose, mannose, galactose and glucose, and the FGOS have certain anti-oxidation ability, and have a high removal rate on hydroxyl free radicals, DPPH free radicals, ABTS free radicals and superoxide anion free radicals.
Owner:JINAN UNIVERSITY
Flarnmulina velutipes polysaccharide and preparation method thereof
InactiveCN106519058AUniform purityImprove immunityOrganic active ingredientsAntiviralsMonosaccharide compositionImmunocompetence
The invention discloses a flarnmulina velutipes polysaccharide and a preparation method thereof. The method includes the preparation steps of hot water extraction, ethanol precipitation, ion-exchange column chromatography and gel column chromatography. The method is simple, easy to implement, safe and reliable, and the flarnmulina velutipes polysaccharide prepared through the method is high in purification concentration, has definite molecular structure characteristics such as molecular weight and monosaccharide composition, contains four monosaccharides including galactose, mannose, fucose and glucose, and can inhibit the Newcastle disease virus and improve the immunocompetence of animals to some extent.
Owner:SHANGHAI ACAD OF AGRI SCI
Acidic pseudo-ginseng polysaccharide and extraction-purification method thereof
ActiveCN110256596ATake advantage ofMaximize utilizationNervous disorderDigestive systemMonosaccharide compositionGalacturonic acid
The invention discloses an acidic pseudo-ginseng polysaccharide and an extraction-purification method thereof. The molecular weight of the acidic pseudo-ginseng polysaccharide is 2500-3000 kDa; the acidic pseudo-ginseng polysaccharide is composed of following mono-saccharides: Rha, Ara, Man, Glc, Gal, and GalA according to a mole ratio of 0.038: 0.045: 0.002: 0.016: 0.031: 0.868; and GalA is galacturonic acid, which has following types of glycosidic bonds: Ara-1<arrow>, Rha-1<arrow>, <arrow>5-Ara-1<arrow>, <arrow>4-GalA-1<arrow>, and <arrow>3,6-Gal-1<arrow> according to a ratio of 0.06:0.04:0.80:0.05. After total saponins are extracted, the residues of pseudo-ginseng are re-extracted to obtain the acidic pseudo-ginseng polysaccharide; the pharmaceutical value of pseudo-ginseng is fully utilized, pseudo-ginseng is better utilized, the method has an important meaning for secondary development of pseudo-ginseng; and the extracted acidic pseudo-ginseng polysaccharide can obviously relieve alcoholic liver injury.
Owner:KUNMING UNIV OF SCI & TECH
Preparation method as well as structural partial characterization and application of gelidium pacificum okam polysaccharide with immunomodulatory effect
ActiveCN108164614AAvoid cytotoxicityInhibition of activationOrganic active ingredientsImmunological disordersChemical structureMonosaccharide composition
The invention relates to gelidium pacificum okam polysaccharide as well as a preparation method and application thereof, and belongs to the field of natural polymers. The invention provides a method for extracting and separating polysaccharide from gelidium pacificum okam, as well as a chemical structure and application of the polysaccharide. The average relative molecular weight is determined byutilizing GPC and the monosaccharide composition is analyzed by using GC-MS; the average relative molecular weight of the gelidium pacificum okam polysaccharide A-11 disclosed by the invention is found to be 28807Da and the gelidium pacificum okam polysaccharide A-11 is mainly prepared from xylose and galactose; in addition, trace amounts of rhamnose, arabinose, fucose, allose, fructose, glucose and mannose are found. Meanwhile, the gelidium pacificum okam polysaccharide A-11 disclosed by the invention has the advantages that the cytotoxicity of LPS-induced THP-1 is significantly inhibited, sothat the cells are prevented from being damaged; besides, the expression of signal factors MyD88 and TRAF-6 in an immune signaling pathway can be regulated so as to enhance human immunity.
Owner:SHANGHAI OCEAN UNIV
Spriulina polysacchride and preparation method thereof
The invention discloses a spriulina polysacchride with the antitumor activity, and a preparation method of the spriulina polysacchride. A derivative of the spriulina polysacchride comprises four monosaccharides of D-glycuronic acid, D-acetylgalactosamine, L-fucose and galactose, and the molecular weight of the derivative is 5000-18000 Da. The extracted single spriulina polysacchride has an obvious inhibiting effect on tumor cells, and thus can be used for preparation of antitumor drugs.
Owner:SHENZHEN NEPTUNUS PHARM CO LTD
Large-leaf yellow tea polysaccharide with blood sugar reducing effect
InactiveCN111793660AImprove polysaccharide yieldImprove biological activityMetabolism disorderFermentationBiotechnologyMonosaccharide composition
The invention discloses a preparation method of large-leaf yellow tea polysaccharide with a blood sugar reducing effect. The preparation method is characterized in that large-leaf yellow tea polysaccharide LYT-2 is prepared by taking large-leaf yellow tea produced from Huoshan as a raw material, performing solid-state fermentation through EM bacteria and carrying out extracting by utilizing a deepeutectic solvent technology; the molecular weight of the polysaccharide compound is 4.38x104 Da, the polysaccharide compound contains 4.98% of binding protein, and the molar ratio of mannose to glucose to arabinose is 2.16:4.83:1 in monosaccharide composition. In-vivo experimental data shows that LYT-2 can obviously reduce the weight and blood sugar level of high-sugar and high-fat mice. The result shows that LYT-2 has good application prospects in the aspects of food, medicine, health care and the like.
Owner:ANHUI UNIVERSITY
Oat bran active polysaccharide extraction and purification method
InactiveCN107540754AThe extraction and purification method is simpleAntioxidantMonosaccharide compositionPurification methods
The invention belongs to the field of oat bran deep-processing, and particularly relates to an oat bran active polysaccharide extraction and purification method. The method includes the steps that polysaccharide is extracted through preprocessing, degreasing and ultrasound-microwave synergistic extraction, and finally the yield, the purity, monosaccharide composition, the antioxidant activity andthe antilipidemia activity of the extracted oat bran active polysaccharide are analyzed. According to the oat bran active polysaccharide extraction and purification method, an oat bran active polysaccharide mixture is extracted by means of an ultrasound-microwave synergistic method, the polysaccharide with the antioxidant and antilipidemia regulating activity is obtained through dialysis, vacuum concentration and freeze-drying, the extraction method is simple, the operation cost is low, extraction duration is short, the yield and the purity of the obtained oat bran active polysaccharide are 8.45% and 93.2% respectively, and the oat bran active polysaccharide has good antioxidant and antilipidemia regulating activity.
Owner:HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
Horseradish tree leaf polysaccharide MLP100-3 component with anti-inflammatory activity and purifying technology and application thereof
InactiveCN108409884AProcess stabilityImprove solubilityAntipyreticAnalgesicsInflammatory factorsMass ratio
The invention relates to a horseradish tree leaf polysaccharide MLP100-3 component with anti-inflammatory activity. The monosaccharide of the horseradish tree leaf polysaccharide MLP100-3 is preparedfrom rhamnose, arabinose, xylose, mannose, glucose and galactose according to a mass ratio proportion of (1.2 to 1.3) to (4.5 to 5.4) to (4.2 to 5.5) to (3.4 to 4.0) to (5.6 to 6.6) to (5.9 to 6.5). The invention further provides a purifying method of the horseradish tree leaf polysaccharide MLP100-3. The horseradish tree leaf polysaccharide MLP100-3 disclosed by the invention show better capacityof inhibiting NO and inflammatory factor TNF-alpha generation in mouse peritoneal macrophage RAW264.7 in-vitro inflammation model. The horseradish tree leaf polysaccharide MLP100-3 disclosed by the invention can be applied to adjusting of body immune function and development and utilization of anti-inflammatory medicine.
Owner:SOUTH CHINA AGRI UNIV
Total cedar polysaccharide and application of total cedar polysaccharide in preparation of immunosuppressive drug
ActiveCN107090049AOrganic active ingredientsAntipyreticImmunosuppressive drugMonosaccharide composition
The invention belongs to the field of traditional Chinese medicine and relates to a total cedar polysaccharide. The polysaccharide is a water-soluble crude polysaccharide extracted and prepared from Sabina pingii var.wilsonii branches and leaves, and the structural characteristics such as sugar content, uronic acid content, protein content, molecular weight distribution and monosaccharide composition of the polysaccharide are represented. Activity determination results indicate that the cedar polysaccharide has an obvious anticomplementary action, the half effective inhibition concentration of a complement activation classical pathway is up to 23-35 micro-g / ml, and the polysaccharide is equivalent to a positive control drug in heparin sodium activity. In addition, the level of mouse peritoneal macrophage cell secretion NO under LPS stimulation can be remarkably inhibited, and it is indicated that the total cedar polysaccharide has a very good anti-inflammatory effect. The total cedar polysaccharide can be used for preparing anti-complement, anti-inflammatory and other immunosuppressive related drugs.
Owner:FUDAN UNIV
Transgenically produced antithrombin III
InactiveUS20080176786A1Peptide/protein ingredientsAntipyreticMonosaccharide compositionPlasma derived
This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition which comprises N-acetylgalactosamine (GalNAc) along with fucose, N-acetylglucosamine, galactose, mannose, and N-acetylneuraminic acid / N-glycolyneuraminic acid. The monosaccharide composition differs with that of plasma derived ATIII (phATIII). It has been found that tgATIII has an increased clearance rate when compared to phATIII.
Owner:GTC BIOTHERAPEUTICS INC
Preparation method and application of tobacco polysaccharide sulfate
ActiveCN103804508AGood conditionGood workmanshipChemical inhibitorsBiotechnologyMonosaccharide composition
The invention belongs to the technical field of tobacco extracts, and particularly relates to a preparation method and application of tobacco polysaccharide sulfate. The preparation method mainly comprises the following steps: extracting tobacco polysaccharide and performing esterified modifying on the tobacco polysaccharide by sulfuric acid. The optimal sulfuric acid modification method is determined according to the monosaccharide constitution type of the tobacco polysaccharide, an optimal reaction condition and an optimal process for the sulfuric acid modification of the tobacco polysaccharide are determined by virtue of a series of experimental verification, the tobacco polysaccharide modified by the sulfuric acid is determined to be suitable for being used as a novel antioxidant by further determining the antioxidant activity of the tobacco polysaccharide modified by the sulfuric acid, so that a novel way is provided for the diversified utilization of tobacco.
Owner:CHINA TOBACCO HENAN IND
Method for quickly detecting monosaccharide composition in medicine mulberry polysaccharide through UPLC-TUV
InactiveCN105974031AEfficient separationStrong specificityComponent separationMonosaccharide compositionRepeatability
The invention discloses a method for rapidly detecting the composition of monosaccharides in mulberry polysaccharides by using UPLC-TUV. (PMP) pre-column derivatization, and then enter the UPLC-TUV system for detection. The invention discloses detection conditions for ultra-high performance liquid chromatography detection. The method is fast, sensitive, good in separation effect and high in repeatability, and can quickly and accurately detect the composition of monosaccharides in the polysaccharide of mulberry fruit.
Owner:SOUTHWEST UNIVERSITY
Ultrasonic-assisted Ganoderma lucidum polysaccharides extraction and acid hydrolysis and monosaccharide composition detection methods
ActiveCN110988213AThorough hydrolysisEasy to removeComponent separationChemical industryMedicinal herbsMonosaccharide composition
The invention, which belongs to the technical field of polysaccharide extraction and detection, particularly relates to ultrasonic-assisted Ganoderma lucidum polysaccharides extraction and acid hydrolysis and monosaccharide composition detection methods. The method for ultrasonic-assisted Ganoderma lucidum polysaccharides extraction and acid hydrolysis has the remarkable advantages of high speed,high efficiency and the like, and rapid analysis and determination of the monosaccharide composition of Ganoderma lucidum polysaccharides in combination with a UPLC-CAD method. The monosaccharide composition and content of the Ganoderma lucidum polysaccharides acid hydrolysis product are compared and analyzed. The results show that the content of xylose in the complete hydrolysate of Ganoderma lucidum polysaccharides is the highest, arabinose has the second content, the contents of rhamnose, galactose and fucose are close, the contents of glucose and mannose are low; and research results provide the data support and technical reference for evaluating the quality of glossy ganoderma medicinal materials and guiding further development and utilization.
Owner:河北天辰阳光科技有限公司
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