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Imperatorin sustained release tablets and preparation method thereof

An imperatorin, sustained-release technology, applied in the field of biomedicine, to achieve the effect of slowing down drug absorption

Inactive Publication Date: 2010-12-01
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the sustained-release preparation with imperatorin as active ingredient

Method used

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  • Imperatorin sustained release tablets and preparation method thereof
  • Imperatorin sustained release tablets and preparation method thereof
  • Imperatorin sustained release tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation method of imperatorin sustained-release tablet comprises the following steps:

[0028] 1) Pass the imperatorin raw material drug and each auxiliary material through an 80-mesh sieve, weigh 50g of imperatorin, 15g of HPMC-100M and 206g of lactose and mix them well, then mix them according to the imperatorin / viscosity Mixture = 10g / 3mL ratio, add 15% (wt) PVP-ethanol-water solution (75%) 15mL, mix thoroughly, pass through a 24 mesh sieve, and wet granulate to obtain wet granules;

[0029] 2) drying the wet granules at 60°C until the water content is 3.0% to obtain dry granules;

[0030] 3) After passing the dry granules through a 24-mesh sieve for granulation, fully mix the dry granules with 24g of carbomer 934NF and 5g of magnesium stearate, and then press them into 1000 tablets to make imperatorin sustained-release tablets .

[0031] Among the made imperatorin sustained-release tablets, in terms of mass fraction, imperatorin is 16.6%, HPMC-100M is 5%, ...

Embodiment 2

[0033] The preparation method of imperatorin sustained-release tablet comprises the following steps:

[0034] 1) Pass the imperatorin crude drug and each auxiliary material through a 80-mesh sieve, weigh 50g of imperatorin, 24g of HPMC-15M and 206g of starch and mix them well, then mix them according to the imperatorin / viscosity Mixture = 10g / 2mL ratio, add 10% (wt) PVP-ethanol-water solution (75%) 10mL, mix thoroughly, pass through a 24 mesh sieve, and wet granulate to obtain wet granules;

[0035] 2) drying the wet granules at 60°C until the water content is 3.0% to obtain dry granules;

[0036] 3) After passing the dry granules through a 24-mesh sieve for grading, fully mix the dry granules with 15g of Carbomer 934NF and 5g of talcum powder, and then press them into 1000 tablets to make imperatorin sustained-release tablets.

[0037] Among the prepared imperatorin sustained-release tablets, in terms of mass fraction, imperatorin is 16.6%, HPMC-15M is 8%, carbomer is 5%, st...

Embodiment 3

[0039] The preparation method of imperatorin sustained-release tablet comprises the following steps:

[0040] 1) Pass the imperatorin raw material drug and each auxiliary material through a 80-mesh sieve, weigh 50g of imperatorin, 30g of HPMC-4M and 200g of dextrin and mix them well, then follow the imperatorin / Adhesive = 10g / 2mL ratio, add 10mL of 60% ethanol, mix thoroughly, pass through a 24-mesh sieve, and wet granulate to obtain wet granules;

[0041] 2) drying the wet granules at 50°C until the water content is 2.5% to obtain dry granules;

[0042] 3) After passing the dry granules through a 24-mesh sieve for grading, fully mix the dry granules with 15 g of polyvinylpyrrolidone and 5 g of talcum powder, and then press them into 1000 tablets to make imperatorin sustained-release tablets.

[0043]Among the prepared imperatorin sustained-release tablets, in terms of mass fraction, imperatorin is 16.7%, HPMC-4M is 10%, polyvinylpyrrolidine is 5%, dextrin is 66.6%, and talc...

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Abstract

The invention discloses imperatorin sustained release tablets and a preparation method thereof. The imperatorin sustained release tablets comprise the following components in percentage by mass: 10.0 to 20.0 percent of imperatorin, 10.0 to 20.0 percent of sustained release medium and the balance of auxiliary material. The sustained release medium is one or more of hydroxypropyl methyl cellulose, polyvinylpyrrolidone, carbomer, sodium carboxymethylcellulose, methylcellulose and ethylcellulose. The imperatorin sustained release tablets provided by the invention can be used for treating hypertension disease. The imperatorin and the sustained release medium are proportioned, therefore the imperatorin can be released in the sustained release medium slowly and stably so as to fulfill the aim of controlling the release rate of the imperatorin.

Description

technical field [0001] The invention relates to the technical field of biomedicine, relates to a new dosage form of imperatorin, in particular to an imperatorin sustained-release tablet and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular disease is a common disease that seriously threatens human life and health, especially the middle-aged and elderly people over 50 years old. Cardiovascular and cerebrovascular diseases have the characteristics of "high incidence, high disability rate, high mortality rate, high recurrence rate, and many complications". According to statistics, the number of people who die from cardiovascular and cerebrovascular diseases in the world is as high as 15 million every year, ranking first among various causes of death. Independent research and development of drugs for the treatment of cardiovascular and cerebrovascular diseases is of great significance, whether it is to maintain human life and health,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/37A61K47/38A61K47/32A61P9/00A61P9/12
Inventor 贺浪冲卢闻王嗣岑李西玲贺建宇张杰贺怀贞
Owner XI AN JIAOTONG UNIV
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