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Pain relieving micro-emulsion pharmaceutical composition gel ointment and preparation method thereof

A technology of gel ointment and composition, applied in the field of microemulsion pharmaceutical composition gel ointment and its preparation, to achieve the effect of enhancing stability and improving compatibility

Inactive Publication Date: 2013-02-06
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to solve the above-mentioned existing problems of pain-relieving plasters, it is necessary to adopt microemulsion technology, but how to effectively apply this technology to pain-relieving plasters and how to solve the compatibility of drugs and substrates is rarely studied in the prior art

Method used

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  • Pain relieving micro-emulsion pharmaceutical composition gel ointment and preparation method thereof
  • Pain relieving micro-emulsion pharmaceutical composition gel ointment and preparation method thereof
  • Pain relieving micro-emulsion pharmaceutical composition gel ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0074] Experimental Example 1: Research on the prescription of microemulsion pharmaceutical composition gel ointment

[0075] One, in the microemulsion pharmaceutical composition gel ointment of the present invention, the influence of gel ointment matrix on microemulsion

[0076] Gel paste base: NP-700, aluminum hydroxide, tartaric acid, aluminum trichloride, aluminum glycolate, EDTA-Na 2 ; Among them, NP-700 is a polymer of 50% polyacrylic acid and 50% sodium polyacrylate, which has good water solubility.

[0077] First, after preparing the microemulsion of the pharmaceutical composition according to the method described in Example 1, add the matrix of the above-mentioned gel ointment respectively, place it on a magnetic stirrer, stir it evenly, and place it for a period of time for observation. The results are shown in Table 1.

[0078] The impact of table 1 gel ointment matrix on microemulsion

[0079]

[0080] As can be seen from the table, after the microemulsion is...

experiment example 2

[0157] Experimental Example 2: Research on transdermal absorption of three forms of pharmaceutical composition gel ointment

[0158] One, the preparation of three forms of pharmaceutical composition gel ointment

[0159] 1. The original pharmaceutical composition gel ointment prescription of the prior art:

[0160] Phase A: NP-700 2g, aluminum glycolate 0.08g, glycerin 12g, PVPP 0.30g

[0161] Phase B: 0.08g tartaric acid, EDTA-Na 2 0.02g, water 4mL

[0162] Phase C: Chuanbai Percolation Solution (4g·mL -1 ), Zanthoxylum bungeanum extract (4g·mL -1 ) each 1mL

[0163] Phase D: borneol 0.25g, mixed volatile oil 0.50mL, absolute ethanol 2mL

[0164] Preparation method: Stir A (NP700, glycerol, aluminum glycerol) and ultrasonically degas, add D (borneol, volatile oil) phase to A phase and stir well. Mix phase C (Chuanxiong Baizhi thick extract, Zanthoxylum Asarum thick extract) evenly, add phases A and D, stir evenly, and ultrasonically remove air bubbles. B (tartaric ac...

experiment example 3

[0269] Experimental example 3: microemulsion gel ointment of the present invention and prior art ointment efficacy comparison

[0270] Analgesic effect on mice

[0271] 1. Experimental materials

[0272] ICR mouse (20 ± 10g), Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (permit number: SCXK (Beijing) 2006-0009); Microemulsion gel ointment of the present invention (prepared according to Example 1), strong Bone Musk Analgesic Ointment (Henan Lingrui Pharmaceutical Co., Ltd., batch number: 100623), medical adhesive plaster (Beijing Lingrui Sanitary Materials Co., Ltd., batch number: 20100929).

[0273] 2. Methods and results

[0274] (1) Effect on pain threshold of mice induced by hot plate

[0275] The mice were randomly divided into five groups, a positive control group, a blank matrix group, a microemulsion gel ointment group of the present invention, a strong bone musk analgesic ointment, and a medical adhesive plaster group. First, put 60 mice on a hot ...

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Abstract

The invention relates to a micro-emulsion pharmaceutical composite gel ointment which is free of oil bleeding on surface. Computability of volatile components and water-soluble bases in the gel ointment is improved. As proved by transdermal absorption tests, transdermal absorption of imperatorin in the pharmaceutical composition gel ointment in the micro-emulsion form is improved, and is close to the transdermal absorption degree of ferulic fluid, and synchronously transdermal absorption of different components different in property can be improved by the micro-emulsion form. Besides, as proved by tests of preliminary stability of the micro-emulsion pharmaceutical composition gel ointment in three forms, the micro-emulsion form is favorable for enhancing stability of volatile components in the formula.

Description

technical field [0001] The invention relates to a microemulsion gel ointment and a preparation method thereof, in particular to a microemulsion type pharmaceutical composition gel ointment for pain relief and a preparation method thereof. Background technique [0002] The prior art has disclosed analgesic plaster and its preparation process. Analgesic plaster is composed of Rhizoma Chuanxiong, Angelica dahurica, Zanthoxylum bungeanum, Asarum, peppermint oil, turpentine, etc., in the 2008 master's thesis "Preparation process and quality standard of analgesic plaster". "Research" discloses the extraction process of the raw material drug of Zhitong plaster, and the percolation of Chuanxiong and Angelica dahurica is extracted to obtain the percolation thick extract (4g·mL -1 ), extract the volatile oil from Zanthoxylum bungeanum and Asarum by steam distillation, and obtain the thick extract (4g·mL -1 ), the prior art also discloses the preparation process of analgesic plaster: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61K9/70A61K47/44A61P29/00A61P25/04
Inventor 吴清
Owner BEIJING UNIV OF CHINESE MEDICINE
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