Duliang compound chinese medicine soft capsules and preparation process thereof

Abstract

The invention discloses a Duliang compound soft capsule and a preparation method thereof. The soft capsule comprises the following components (per 1,000 capsules) angelica dahurica 1,128 g, ligusticum chuanxiong 282 g, and soybean oil 324-432 g. The preparation method comprises the following steps of extracting angelica dahurica and ligusticum chuanxiong with supercritical carbon dioxide to obtain volatile oil and residue; decocting the residue in water, precipitating with ethanol, vacuum drying at low temperature, and making into soft capsule. The soft capsule uses soft capsule shell material to wrap medicinal content, so as to mask the bitter taste and unpleasant taste of the medicinal content. The inventive soft capsule also has the advantages of easy administration, rapid release of medicinal content after disintegration of the soft capsule shell material, quick action, remarkably increased content of active ingredients such as imperatorin by using supercritical carbon dioxide extraction technique, high bioavailability of medicinal content, reduced impurities of extract powder, more accurately dosage, remarkably reduced particle size of medicinal powder, quick absorption during clinical treatment, good therapeutic effect, and no toxic or side effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating migraine and a preparation process thereof, in particular to Duliang soft capsule and a preparation process thereof. Background technique [0002] Duliang Pills originated from "Bai Yi Xuan Fang" by Wang Yu in the Song Dynasty. It is a classic prescription. It is mainly composed of Angelica dahurica and Chuanxiong in a certain proportion. Plants of the large intestine, lungs. Spicy plants can remove blood stasis and regulate qi, so the root of Angelica dahurica has the ability to relieve head apoplexy and cold. The rhizome of Chuanxiong is also pungent in taste and warm in nature, but it acts on the liver, gallbladder and pericardium. It has the function of improving Qi and blood circulation and relieving pain. Modern pharmaceutical research shows that the root of Angelica dahurica contains imperatorin, isoimperatorin, angelica, angelica ether and other ingredients, whic...

AI Technical Summary

Problems solved by technology

However, the Duliang pills made in this way have the problems of being thick, large, and black, and the production quality is not stable, and the curative effect is not guaranteed. It is difficult for patients to accept it when taking it, and the clinical use is limited.

In order to solve the above-mentioned defects, the Duliang drop pills of the prior art have improved the traditional preparation process. Currently, the commercially available Duliang drop pills are a combination of a certain amount of extract solid or liquid medicine and a matrix such as polyethylene glycol or other medicinal materials. After heating, melting and mixing, it is dropped into the immiscible condensate, and the preparation is made by shrinking and condensing. The production of Duliang dripping pills uses more pharmaceutical excipients such as polyethylene glycol, so the content of active ingredients is relatively low. Some, the dosage of its medicinal active ingredients is insufficient, and the clinical curative effect is poor; and Duliang dripping pills are made by heating, melting and mixing the medicinal ingredients and the auxiliary material polyethylene glycol, and then dropping them into the immiscible condensate, shrinking and condensing. Therefore, part of the medicine is exposed on the surface of the pill, so the drug stability of the drop pill is not ideal, and it is not good to cover the uncomfortable bitter taste and peculiar smell of the medicine content. prone to nausea

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