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Content determination method for orifice-freeing rhinitis tablet

A technology of Tongqiao Biyan Tablet and its determination method, which is applied in the field of content determination of Chinese patent medicines, can solve the problems that the six active ingredients of Tongqiao Biyan Tablet cannot be detected at the same time, the preparation method is complicated, and takes a long time, so as to shorten the time of content determination and improve the The effect of detection efficiency

Active Publication Date: 2018-02-13
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"The preparation method of the test product is complicated and time-consuming.
Although it controls the two content detection indicators, it uses two different detection methods, which are costly, time-consuming and inefficient
[0010] None of the above methods can simultaneously detect the 6 active ingredients in Tongqiao Biyan Tablets
Moreover, these methods take a long time to detect, have low efficiency, consume a lot of organic solvents, and cannot quickly and accurately quantitatively analyze the ingredients of multi-flavored medicines in Tongqiao Biyan Tablets at the same time.

Method used

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  • Content determination method for orifice-freeing rhinitis tablet
  • Content determination method for orifice-freeing rhinitis tablet
  • Content determination method for orifice-freeing rhinitis tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 The active ingredients acteoside, 5-O-methylvisamigoside, acteosin, magnolanin, imperatorin, and isoimperatorin in Tongqiao Biyan Tablets were detected according to the following method. content:

[0047](1) Preparation of the test solution: take 1.0 g of Tongqiao Biyan Tablet powder, accurately weigh it, put it in a 100 mL conical flask with a stopper, accurately add 50 mL of methanol with a volume fraction of 80%, weigh, extract by 100W, 25kHz ultrasound for 45min, and put Cool, weigh again, make up for the weight loss with 80% methanol by volume fraction, filter with a 0.22 μm microporous membrane, and take the subsequent filtrate as the test solution;

[0048] (2) Preparation of reference solution: take acteoside reference substance, 5-O-methylvisamidol glycoside reference substance, calycosin glucoside reference substance, imperatorin reference substance, isoimperatorin The plain reference substance and the magnolanin reference substance were dissolved i...

Embodiment 2

[0053] Example 2 The active ingredients in Tongqiao Biyan Tablets were detected according to the following method: acteoside, 5-O-methyl visamidol glycoside, acteoisoflavone glycoside, magnolanin, imperatorin, isoimperatorin content:

[0054] (1) Preparation of the test solution: take 3.0 g of Tongqiao Biyan Tablet powder, accurately weigh it, put it in a 200 mL volumetric flask, add 30 mL of methanol with a volume fraction of 60% accurately, weigh it, extract it with 100 W, 25 kHz ultrasonic wave for 30 min, let it cool, Weigh again, make up for the weight loss with 60% methanol by volume fraction, filter with a 0.22 μm microporous membrane, and take the subsequent filtrate as the test solution;

[0055] (2) Preparation of reference solution: take acteoside reference substance, 5-O-methylvisamidol glycoside reference substance, calycosin glucoside reference substance, imperatorin reference substance, isoimperatorin The plain reference substance and the magnolanin reference s...

Embodiment 3

[0060] Example 3 The active ingredients acteoside, 5-O-methyl visamidol glycoside, acteoisoflavone glycoside, magnolanin, imperatorin, and isoimperatorin in Tongqiao Biyan Tablets were detected according to the following method. content:

[0061] (1) Preparation of the test solution: Take 2.0g of Tongqiao Biyan Tablet powder, accurately weigh it, put it in a 150mL conical flask with a stopper, add 60mL of methanol with a volume fraction of 70% precisely, weigh it, extract it with 100W, 25kHz ultrasound for 60min, put Cool, weigh again, make up for the weight loss with 70% methanol by volume fraction, filter with a 0.22 μm microporous membrane, and take the subsequent filtrate as the test solution;

[0062] (2) Preparation of reference solution: take acteoside reference substance, 5-O-methylvisamidol glycoside reference substance, calycosin glucoside reference substance, imperatorin reference substance, isoimperatorin The plain reference substance and the magnolanin reference ...

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Abstract

The invention relates to a content determination method for an orifice-freeing rhinitis tablet, in particular to a content determination method for effective components such as cimicifugoside, 5-O-methylvisamminol, calycosin-7-glucoside, magnolin, imperatorin and isoimperatorin in the orifice-freeing rhinitis tablet. The method comprises preparation of a test solution, preparation of a control solution and determination with an UPLC (Ultra Performance Liquid Chromatography) method. By adopting the content determination method provided by the invention, a stable detection baseline, a high separation degree, high detection accuracy and high stability are achieved during determination; the content determination time is shortened greatly, the detection efficiency is increased stably, the dosage of a toxic chemical reagent is reduced greatly, and the method is more economical and environmentally friendly; meanwhile, multi-index component detection is performed, and a rapid, effective and feasible detection method is provided for the establishment of a liquid-phase fingerprinting database of the orifice-freeing rhinitis tablet; moreover, and a more comprehensive method for quantitativelycomparing and inspecting the stability of the effective components can be provided for the stability inspection of the orifice-freeing rhinitis tablet.

Description

technical field [0001] The present invention relates to the determination of the content of Chinese patent medicines, more specifically, it relates to active ingredients acteoside, 5-O-methyl visamidol glycoside, actecoside, magnolanin and imperatorin in Tongqiao Biyan Tablets And the content determination method of isoimperatorin. Background technique [0002] Tongqiao Biyan Tablet is a pure Chinese medicine compound preparation made from six Chinese herbal medicines such as fried cocklebur, windproof, astragalus, angelica, magnolia, fried Atractylodes macrocephala, and mint. It is used for the severity of nasal congestion, runny or cloudy nasal discharge, forehead headache, chronic rhinitis, allergic rhinitis, sinusitis and other diseases caused by wind-heat accumulation in the lung and deficiency of the external surface. The main active ingredients in Tongqiao Biyan Tablets are: acteoside, 5-O-methylvisamidol glycoside, acteosin glucoside, imperatorin, isoimperatorin and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 张英帅凌勇根刘逆夫龚云伍实花
Owner ZHUZHOU QIANJIN PHARMA
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