The invention provides a high-yield and cultivation method of Juhuaxin pomelo. The method comprises the following steps of (1) selecting an orchard site; (2) digging a hole and improving soil; (3) field planting tree stocks: selecting poncirus trifoliate stock or citrus grandis to graft seedlings; (4) pruning in a natural open centre shape, promoting spring shoots, shearing summer shoots and removing autumn shoots; (5) managing flowers and fruits: spraying gibberellin (CA3) 50mg / kg, 0.3 percent of monopotassium phosphate and 0.1 percent of borax on leaves to prevent fruit drop during a full-blossom period. According to the high-yield and cultivation method of the Juhuaxin pomelo, the poncirus trifoliate stock is adopted to graft the seedlings, so that after field planting, the root system is developed, the stress resistance is strong, the appetency is strong, the adaptability is wide, the tree form is semi-dwarf, the tree potential is strong and healthy, the close planting is suitable for being carried out, early mature and high yield is realized, and the quality is good. The citrus grandis is adopted to graft the seedlings, so that after field planting, the root system is developed, the stress resistance is strong, the adaptability is wide, the appetency is favorable, the tree potential is strong and healthy, the tree form is arborescent, the fruiting is delayed, and the high and stable yield can be achieved during the middle and later periods.