Preparation of pure magnolol

Abstract

A process for preparing high-purity magnolol from magnolia bark includes such steps as pulverizing, thermal extracting in ethyl acetate, vacuum concentrating while recovering ethyl acetate, extracting by petroleum ether 4-5 times, collecting liquid extract, concentrating is rotary evaporator, adding the aqueous solution of NaOH, back extracting 4-5 times, and drying deposit in air.

Description

Technical field [0001] The invention relates to a preparation technology of a single effective ingredient of a medicinal plant, in particular a preparation technology of high-purity magnolol. technical background [0002] The traditional preparation route of magnolol is to extract magnolol from the traditional Chinese medicine Magnolia officinalis by alcohol heat reflux extraction method, and then extract it with ether or ester and concentrate it into an extract, and finally use column chromatography to analyze the extract mixture Purify. At present, in the preparation technology of magnolol that has been reported, in addition to traditional technology or direct column chromatography after alcohol extraction similar to traditional technology, it also includes supercritical fluid extraction technology, lye percolation or lye extraction followed by extraction and purification. technology. [0003] Using the traditional preparation route, the extraction rate of the alcohol-extracted...

AI Technical Summary

Problems solved by technology

[0003] Using the traditional preparation route, the extraction rate of magnolol by alcohol extraction is generally 60-70%, which is not very high. The purification step requires the use of column separation technology. The cost of industrial preparation is high, and it is difficult to achieve large-scale preparation.

Using the supercritical fluid extraction route, the direct extract is often a mixture, the purity is not high, and needs to be further refined, and the supercritical fluid extraction equipment is expensive, and the one-time investment is too high, so it is not easy to popularize

Adopt lye percolation or lye extraction back extraction and purification technology, literature does not report the purity of product, just confirms that extract is pure magnolol according to the result of thin-layer chromatographic separation and the result of infrared, ultraviolet spectroscopic analysis, draws thus The conclusion of a higher yield is obviously not convincing

We know that the resolution of thin-layer chromatography is not high, and some substances with similar properties cannot be separated on it. Using high-resolution separation techniques, it can be seen that the single substance identified on thin-layer chromatography is not necessarily Pure; some mixtures of structures cannot be resolved by UV and IR spectroscopy

Our similar experiments showed that the pure material identified only by spectral analysis and chromatographic separation data was not very pure as confirmed by thermal analysis techniques