Michael addition product of ferrocene-based chalcone and ethyl acetoacetate and preparation method thereof

Abstract

The invention provides a Michael addition product of ferrocene-based chalcone and ethyl acetoacetate and a preparation method thereof. The preparation method comprises the steps: adding A mol of ferrocene-based chalcone and B mol of ethyl acetoacetate into a dry reaction container, adding an alkaline substance as a catalyst, and grinding until the raw materials are subjected to complete reaction, wherein the ratio of A to B is 1:1; washing the product obtained from the reaction with water, carrying out suction filtration, recrystallizing the filter cake, and thus obtaining the Michael addition product of ferrocene-based chalcone and ethyl acetoacetate. The preparation method has the advantages of simple operation, short reaction time, mild reaction conditions, and low equipment requirements, the reaction is carried out only with grinding, at the same time, the catalyst is cheap and easy to get, the yield of the obtained product is up to 91.3% or more, the purity is high, and the preparation method is a green, simple and fast method for preparation of the Michael addition product of ferrocene-based chalcone and ethyl acetoacetate.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, in particular to a method for preparing a Michael addition product of ferrocenyl chalcone and ethyl acetoacetate. Background technique [0002] Chalcones are a class of natural organic compounds that exist in medicinal plants such as licorice and safflower. Due to their greater flexibility in molecular structure, they can bind to different receptors, so they have a wide range of biological activities, such as Antitumor, inhibit and clear oxygen free radicals, antibacterial, antiviral and other biological activities. In recent years, ferrocenylchalcone and its derivatives have been used as intermediates in organic synthesis, and their excellent properties have attracted more and more people's interest. [0003] Carbon-carbon bond condensation and corresponding functional group transformation are the most basic molecular reaction in organic synthesis, so the research on this aspect is gradually a...

AI Technical Summary

Problems solved by technology

[0004] The Micheal addition reaction under traditional conditions is mostly obtained by reflux reaction in an organic solvent under the action of a strong base, but this method is often accompanied by many side reactions, such as the self-condensation of the substrate, rearrangement, and the formation of the addition product. Further condensation or cracking, etc., resulting in an unsatisfactory yield, which brings a lot of trouble to the purification of the product. At the same time, the reflux reaction time is very long, and the organic solvent seriously pollutes the environment, which does not conform to the concept of green chemistry.

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