126 results about "Neurotic delinquency" patented technology

The present invention relates to the use of 3-sbustituted phthalide or analogue for preparing the medicine for treating Alzheimer disease or other neurotic disease. The structural formula is shown in the right formula. Filtering is executed through a high-effective living model which integrates gene technique and biological technique. The research shows that most compounds have a certain function that the defective individual recovers learning capacity, wherein a plurality of specific compounds represent better activity. The learning capacity of deflective individual can be recovered for above 85%. Furthermore a stable treating effect can be shown in a plurality of tests.

The present invention is directed to the use of angiotensin II receptor I (AT1 receptor) antagonists for the treatment, prophylaxis, reversal and / or symptomatic relief of a neuropathic condition, especially a peripheral neuropathic condition such as painful diabetic neuropathy, in vertebrate animals and particularly in human subjects. The present invention also discloses the use of AT1 receptor antagonists for preventing, attenuating or reversing the development of reduced opioid sensitivity, and more particularly reduced opioid analgesic sensitivity, in individuals and especially in individuals having, or at risk of developing, a neuropathic condition.

The present invention relates to the field of pharmaceutical chemistry and drug treatment. Specifically the present invention relates to tetrahydropyridothiazole compounds represented by the following general formula I, a preparation method, drug compositions containing the same, and uses thereof. The compounds represented by the general formula I in the present invention are selective inhibitors acting on histonedeacetylase-6, and provide inhibition effects for deacetylation action of the histonedeacetylase, particularly for deacetylation action of the histonedeacetylase-6 so as to produce biological activities, such that the present invention further relates to applications of the compounds in preparation of drugs for treatment of histonedeacetylase-6 inhibitor mediated diseases, specifically in preparation of drugs for treatment of tumors, neurological diseases, and associated diseases.

The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and materials for treating seizure and seizure disorders, epilepsy, status epilepticus, migraine, spreading depression, intracranial hypertension; for treating the pathophysiological effects of head trauma, stroke, ischemia and hypoxia; for treating or protecting from the pathophysiological effects of neurotoxic agents such as ethanol; and for treating neurophsyciatric disorders and central nervous system edema by administering agents that modulate ionic concentrations and / or ionic gradients in the brain, particularly ion-dependent or cation-chloride cotransporter antagonists. Electrolyte cotransport antagonists and combinations of such compositions with other agents for treating various conditions are disclosed. The present invention also relates to methods and compositions for treating pain by administering ion-dependent cotransporter antagonists. Methods and compositions for enhancing cortical function, for example, in centers of cognition, learning and memory, by administering ion-dependent cotransporter agonists are disclosed.

The invention provides an implanted multifunctional double-side micro brain electrode array chip. Three electric pulse stimulation electrodes, four electrochemical detection electrodes and seven brain electric detection electrodes are distributed on each surface of an electrode pole; the electric pulse stimulation electrodes, the brain electric detection electrodes and the electrochemical detection electrodes are symmetrically distributed on the central axis of the two surfaces of the electrode pole; the electrochemical detection electrodes and the brain electric detection electrodes are connected to electrode lead interface welding discs via detection electrode leads; the electric pulse stimulation electrodes are connected to the electrode lead interface welding discs via stimulation electrode leads; and the electrode lead interface welding discs are symmetrically distributed at the two sides of the central axis of the two surfaces of an electrode handle. The electrodes of different functions are integrated on one chip so that electric pulse stimulation of deep brain tissues can be realized and the brain electric signals and electrochemical signals of the specific areas of the brain can be detected, the chip is suitable for being implanted in the brain for a long time and thus treatment and research of neurological diseases can be assisted.

The present invention discloses the application of bakuchiol compound in preparing medicine for treating psychogenic diseases and neurogenic diseases. Extracorporeal experiment and animal experiment show that the bakuchiol compound can suppressing dopamine transport protein, noradrenalin transport protein and 5-hydroxy tryptamine transport protein selectively, and no influence on gamma-aminobutyric acid transport protein and L-glytamic acid transport protein, no cytotoxicity, and antidepressant effect higher than available antidepressant medicine amfebutamoe hydrochloride. Therefore, the bakuchiol compound has excellent marketability in preparing medicine for treating psychogenic diseases and neurogenic diseases.

The invention provides a traditional Chinese medicine pillow for soothing nerves and a preparation method thereof. The traditional Chinese medicine pillow comprises a pillow interior and a pillowcase; materials filled in the pillow interior comprises the components of aizoon stonecrop herb, concha ostreae, magnet, acanthopanax, concha margaritiferallsta, erosaria caputserpentis, amethyst, poria with hostwood, spina date seed, caulis polygoni multiflori, longan aril, lotus seed, lily, lucid ganoderma, cortex albiziae, folium apocyni veneti, rhizoma anemones altaicae, ginseng, polygala tenuifolia, platycladi seed, stigma croci, valerian, fructus choerospondiatis, cinnabar, physochlaina macrophylla and henbane. The preparation method comprises the following steps: cleaning and drying the raw materials; grinding; filtering through a filter net to obtain raw material powder; uniformly mixing the raw material powder according to the ratio; sterilizing through an ultraviolet lamp; packaging into a silk pillow interior; then sleeving the pillowcase to obtain the traditional Chinese medicine pillow. According to the traditional Chinese medicine pillow for soothing nerves and the preparation method thereof, all components in the formula are reasonably matched, which is beneficial for helping sleeping and can treat neurological disease well; all the components coordinately act and complement each other; the preparation process is simple, and mass production applies.

The invention discloses application of artemisinin and derivatives thereof in preparing medicaments for preventing and treating neurological diseases. In the application, the nerve cell line of rat adrenal pheochromocytoma PC12, retinal nerve cell line RGC-5 and primary cortical neuron are on behalf of experiment objects, sodium nitroprusside and hydrogen peroxide are used to simulate and induce oxidative stress, cell apoptosis and other cell injuries of nerve cells. Researches discover that the artemisinin has a protective effect on sodium nitroprusside and hydrogen peroxide induced cell injury, the protective effect mechanism of the artemisinin and derivatives thereof is primarily discussed, and results indicate that the artemisinin and derivatives thereof can be used as nerve protection medicaments for preventing and treating various neurological diseases, such as various neurodegenerative diseases, acute and chronic neurodegenerative diseases, neurological eye disease and the those neurological diseases mainly related to oxidative stress injuries and cell apoptosis. The application brings a new direction to treatment and prevention of neurological diseases.

The present invention discloses an application of flavone compound or its derivative in preparation of medicine for curing psychic disease and nervous disease. Said invention also discloses a medicine composition containing flavone compound or its derivative. Said invention also provides an excitant of dopamine transport protein firstly, and the tests show that the dopamine transport protein can be excited.

The invention belongs to the field of medicinal chemistry, and relates to flavonoid derivatives and application thereof in preparing a medicinal composition for treating diseases related with dopamine transport protein. The flavonoid derivatives of the invention have a structure of a formula (I). A biological evaluation result shows that a compound of the invention represents better activation function on the dopamine transport protein compared with the prior art, can adjust the transport of dopamine by promoting the transport function of the dopamine transport protein, maintain extracellular dopamine concentration balance, and can be prepared into dopamine transport protein agonist used for treating mental diseases and neurological diseases. R1 is selected from hydroxy, alkoxyl of C1 to C8, ester group of C1 to C8, glucoside and halogen; R2 is selected from hydrogen, C7-hydroxy, C7-alkoxyl, C7-ester and C7-halogen respectively; and R3 is selected from the hydrogen respectively, or contain one or a plurality of substituent groups on a benzene ring, wherein the substituent groups are selected from the hydroxy, alkoxyl, ester group, aryl (heteroaryl), the hydrogen and glycoside group respectively.

Trauma, surgery, inflammation, subfertility, lactation problems, gut disorders, infant nutrition, cancer, arthritis and other joint problems, vascular problems and cardio-or cerebro vascular problems, ischaemia, aging, impaired immune function, burns, sepsis, malnutrition, problems with liver or kidneys, malaria, cystic fibrosis, migraine, neurological problems, respiratory infections, improvement of sports results, muscle soreness, drug intoxication and pain can be treated with a nutritional composition containing effective amounts of ribose and folic acid, optionally combined with other components such as niacin, histidine, glutamine, orotate, vitamin B6 and other components.

The invention discloses 1,2,3,4-tetrahydroisoquinoline derivatives, and a preparation method and application thereof. The invention particularly relates to 1,2,3,4-tetrahydroisoquinoline derivatives having the structure of formula (I) shown in the specification, and a preparation method and application thereof, wherein substituents in the formula (I) are as defined in the specification. Such series of compounds are active for treating, preventing or relieving neuropathy or neuropathic pain, are applicable to the development of drugs for treating primary neuropathy, secondary neuropathy, peripheral neuropathy, neuropathy due to mechanical nerve injury or biochemical nerve injury, painful diabetic neuropathy (PDN) or related neuropathic diseases, and have a promising application prospect.

The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNav1.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. Methods for prevention and treatment of neurological disorders, including, for example, seizures and seizure disorders, including Lennox-Gastaut Syndrome, Dravet syndrome, epileptic encephalopathies, autism, Familial hemiplegic migraine (FHM), anxiety disorders, including Post-traumatic stress disorder (PTSD), panic disorder and obsessive-compulsive disorder, neuropathic pain, and Rett syndrome by administration of these compounds are also provided.

A medicinal preparation for preventing and / or treating psychoneurotic diseases such as integration dysfunction and Alzheimer's disease which contains tropisetron or its pharmaceutically acceptable salt as the active ingredient.

PCT No. PCT / JP97 / 00954 Sec. 371 Date Jan. 21, 1999 Sec. 102(e) Date Jan. 21, 1999 PCT Filed Mar. 24, 1997 PCT Pub. No. WO97 / 35577 PCT Pub. Date Oct. 2, 1997(+)-N,N'-Propylene dinicotinamide or pharmaceutically acceptable salts thereof are outstanding drugs of high safety that can heal or ameliorate spinal cord injuries, prevent the transition from an incomplete cord injury to a complete injury, and minimize the consequences of spinal cord injuries including neurological disorders such as quadriplegia, paralysis of the respiratory muscle, damage to sensory functions and impairment of reflex functions, as well as impaired urinating or defecating functions.

The invention relates to a high-purity salvianolic acid B and a preparation method and application thereof. The defects of the prior art are that the purity of the obtained salvianolic acid B is lowerthan 92 percent, the steps for obtaining the salvianolic acid B of which the purity is above 92 percent are quite a lot, the cost is very high, and the prior art cannot be applied to industrial production. The preparation method consists of the steps of extraction, pre-column, polyamide chromatography and collection, wherein the pre-column comprises the following steps: filtering an extracting solution and then putting the same on a DA-201 type polar resin column, and using water to remove impurities firstly; then using low-concentration lower alcohol with 1 to 5 carbon atoms to remove the impurities; using the lower alcohol with 1 to 5 carbon atoms to perform desorption; collecting the components containing the salvianolic acid B section by section; and performing decompression and concentration. The salvianolic acid B is applied to the medicaments for treating cardiovascular and cerebrovascular diseases, kidney diseases, pneumonia, pulmonary heart diseases, pancreatitis, diabetes, cervical spondylosis, retinal vascular diseases, retinal nerve diseases, migraine headaches, chronic gastritis, dizziness, bone diseases, and Alzheimer's diseases.

The invention discloses a bathing agent for artificial hot springs and process for preparing same, wherein the formulation comprises sodium sulfate powder 45-55%, sodium chloride 35-45%, soda 5-20%, potassium chloride 1-5%, sodium borate 1-5%, magnesium sulfate 1-5%, potassium iodide 0-0.3%. The invention also discloses the process for preparing the bathing agent for artificial hot springs, which can be used for the subsidiary treatment of skin diseases, rheumatalgia, arthritis, nerve diseases, gynaecologic diseases and cardiovascular diseases.

The invention provides a dry electrode system for detecting electroencephalogram. The system comprises a signal acquisition module, a pre-amplification module and a power module. The signal acquisition module is used for acquiring and outputting original electroencephalogram. The pre-amplification module is used for amplifying the original electroencephalogram and outputting the amplified electroencephalogram. The power module is used for supplying power to the pre-amplification module and outputting the amplified electroencephalogram to the exterior. The problems that contact resistance of an electroencephalogram dry electrode is large, and interference by the environment is likely to happen are solved, the electroencephalogram can be conveniently, efficiently and accurately detected, and wide application prospects are achieved on neurological disease diagnosis and treatment, brain-machine interfaces and limb rehabilitation.

There are disclosed methods for inhibiting dynamin-dependent endocytosis in cells comprising treating the cells with an effective amount of a compound of formula (I), or a dimeric tyrphostin, physiologically acceptable salt, or prodrug thereof. Compounds useful in the methods described are also provided. The inhibition of dynamin-dependent endocytosis of cells is applicable to the treatment of epilepsy and neurological disorders and conditions.

This invention is directed to methods of preventing or treating neurological or neuropathic diseases or conditions associated with excessive inflammation, neurodegeneration, neuro-remodeling, and axonal / neurite retraction. Particularly, this invention relates to methods treating neurological or neuropathic diseases such as cerebral ischemia, stroke, neuropathic pain, spinal cord injury, Alzheimer's disease, and multiple sclerosis, using novel rho kinase inhibitor compounds. The method comprises identifying a subject in need of the treatment, and administering to the subject an effective amount of a novel rho kinase inhibitor compound to treat the disease.

The invention discloses application of superparamagnetic iron oxide nanoparticles in preparation of nerve magnetic stimulation enhancers for treating neurogenic diseases. On the basis of magnetic nanomaterials and the action of a magnetic field, method and system construction for magnetic stimulation of deep brain nerves are realized. The application has the advantages that the high compatibilityand magnetic field response characteristics of the superparamagnetic iron oxide nanoparticles are utilized to feed the superparamagnetic iron oxide nanoparticles to a specific brain region, the magnetic nanoparticles amplify the magnetic field effect under the action of a specific external magnetic field, surrounding nerve cells are stimulated, activation of neural circuits is realized, and accordingly, some neurogenic diseases can be treated.

The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

The invention relates to a traditional Chinese medicine composition for treating neurological diseases and a preparation method thereof, and belongs to the field of traditional Chinese medicine treatment of the neurological diseases, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-80 parts of radix astragali, 5-50 parts of radix et rhizoma asari, 5-50 parts of radix et rhizoma salviae miltiorrhizae, 5-50 parts of ramulus cinnamomi, 4-40 parts of rhizoma smilacis glabrae, 2-25 parts of radix angelicae sinensis, 3-30 parts of rhizoma chuanxiong, 2-20 parts of herba ephedrae, 3-40 parts of radix aconiti lateralis, 2-25 parts of radix paeoniae rubra, 5-40 parts of radix achyranthis bidentatae, and 5-50 parts of rhizoma anemarrhenae, the traditional Chinese medicine composition provided by the invention can be used for treating diabetic neuropathy, Guillain-Barre syndrome, sciatica, and peripheral neuritis.

It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons. Interestingly, hedgehog not only promotes dopaminergic neuron survival, but also promotes the survival of midbrain GABA-immunoreactive (GABA-ir) neurons.

The invention discloses a method for in-situ measuring iron content in a biological tissue sample by adopting isotopic dilution LA-ICP-MS (laser ablation inductively coupled plasma mass spectrometry). The method comprises the following steps of building a sample boundary by adopting a tissue anti-dropping material for a biological section sample, and adding quantitative isotopic dilution agent in a boundary to adequately exchange isotope of the tissue sample; optimizing the addition way of the isotopic dilution agent, the isotopic balance time and the condition of the in-situ isotopic ratio measurement technology; in-situ measuring the iron content in the uniform tissue section sample of goat brain and beef liver by adopting the isotopic dilution-LA-ICP-MS technology, wherein the measurement result is consistent with that of the microwave digestion-isotopic dilution method. The method can be further applied to the in-situ and microcell quantitative measurement and imaging analysis of metal elements in the biological tissue section sample in clinical process, and an important clinical significance for establishing the connection between the distribution variation of iron element in the tissue sample and the typical neurological disease can be realized.

The invention relates to a phenyl ring-aromatic ring cascaded micro-molecular organic compound which can be used as a protein-tyrosine-phosphatase subtype inhibitor and is shown in a general formula I as described in the specification. The compound can be used as a tool compound for research on the biological functions of a variety of subtypes of a protein-tyrosine-phosphatase family in cell signal transduction, so novel means is provided for prevention and treatment of cancers, metabolism and immunological diseases, cardiovascular diseases and nervous diseases. The invention also relates to a preparation method and medicinal application of the compound.

The invention relates to a medical water-soluble cannabisdiol CBD preparation formula. The preparation is prepared from, by weight, 60-80 parts of water-soluble cannabisdiol CBD, 5-10 parts of water-soluble hypocannabidiol CBDa, 1-3 parts of and water-soluble cannabigerol CBG, 1-5 parts of water-soluble cannabis Elson CBE, 2-3 parts of water-soluble cannabis color CBC and 5-8 parts of water-soluble CBN. Compared with the prior art, the formula has the advantages that the water-soluble cannabisdiol CBD serves as the main component, does not contain addictive ingredients, has no psychoactive activity, does not produce dependence, and repairs cells and neuronal systems, and meanwhile the pharmacological action is achieved for resisting spasticity, anxiety, neurogenic diseases, pain and cancer; the preparation can be made to be effervescent tablets, dissolved medicines, capsules, soft capsules, tablets, sprays, emulsified oils, creams, transdermal patches, suppositories, expectorant tablets and sprays, the bioavailability is high, and the formula can play a good effect on cell repair of postoperative chemotherapy and radiotherapy for cancer and treatment of neuropathic diseases.

The invention relates to the human being or animal nerve cell extracts and the application thereof for inducing and differentiating the mesenchyme to nerve cell in vitro, which provides a new induction reagent for mesenchym induction technology. The preparation steps are: removing blood cell, connective tissue and capsule from nerve cell tissue, conducting cell homogenate, cell disrupting, precipitating, taking supernatant, separating and removing substance with the molecular weight over 200 thousand Da, subpackaging. It can be applied both in the organic combination of nerve cell extractive and the prior part and in the preparation of reagent box. The invention in the application for inducing and differentiating the mesenchym into nerve cell shows a favorable effect, with the induction differentiation rate being over 90%. The inducing differentiated nerve cell can be used for transplantation to treat multiple nerve diseases, having a favorable application prospect in clinical practice