141results about How to "Good antithrombotic" patented technology

The invention provides an artificial blood vessel loaded with pseudo-ginseng medicines, and a preparation method and application for the artificial blood vessel. The artificial blood vessel sequentially consists of an inner layer, a middle layer and an outer layer which are closely connected with one another; the outer layer consists of nondegradable polymer materials; the middle layer consists of degradable high polymer materials and pseudo-ginseng powder distributed on the surface and / or the inside of the middle layer; the inner layer consists of degradable natural biological materials and pseudo-ginseng powder distributed on the surface and / or the inside of the inner layer; the mass percent of the pseudo-ginseng powder in the inner layer is larger than 5%; the content of the pseudo-ginseng powder in the middle layer is higher than that of the pseudo-ginseng powder in the inner layer; the outer layer is a nondegradable layer and is mainly used for protecting and replacing a blood vessel for a long time; the middle layer is a long-acting antithrombosis layer, can degrade high polymers, and can slowly release medicines so as to realize a long-acting antithrombosis effect; and the inner layer is a quick degrading layer, when the blood vessel is punctured and injured by a foreign object, the pseudo-ginseng medicines wrapped in the blood vessel are directly exposed on a wound, blood is stopped quickly, and the artificial blood vessel is particularly suitable for application to products such as hematodialysis.

The present invention provides a new application of tanshin polyphenolic acid B in preparing medicine for treating tumor. Extraneous research shows that tanshin polyphenolic acid B has the function of killing tumor cell and animal test shows its antineoplastic effect. In the present invention, the cation in the salt of tanshin polyphenolic acid B may be Fe ion, Na ion, K ion, Ca ion or Mg ion, preferably Mg ion. The said medicine may be in any medicine form, oral liquid, injection, tablet or capsule.

The invention relates to a heparin derivative polysaccharide mixture and a preparation method and a medicinal composition thereof. Specifically, the heparin derivative polysaccharide mixture of the invention is a degradation product of heparin or heparin ester or heparin ester salt and is characterized in that the weight-average molecular weight is 3,100 to 4,500 Daltons, the activity of anti-coagulation factor Xa is high, and the activity of anti-coagulation factor IIa is low. The heparin derivative polysaccharide mixture of the invention has excellent antithrombotic performance, low side effect, and has no residues of adverse components such as organic base and dermatan sulfate and the like.

The invention relates to a novel non-virus cationic gene vector and the process for preparation. The process for preparation comprises the following steps: firstly, utilizing an oxygen anion polymerization method to synthesize polycation type electrolyte and segmented copolymer which contains polycation type electrolyte, and then leading polycation type electrolyte and DNA to mutually compound in salting liquid whose PH is 7.4 and buffer solution, achieving the packing of polycation type electrolyte to DNA, and the surface of DNA / polycation compound which is formed is with positive charge, adding segmented copolymer MePEO-b-PMAA which contains polycation type electrolyte in a system, leading PMAA segment with negative charge to be absorbed on the surface of the DNA / polycation compound through electrostatic force action and hydrogen bond effect, achieving the packing to compounds. The novel non-virus cationic gene vector has the advantages of mild polymerization reaction condition, controllable molecular weight, narrow molecular weight distribution, simple process for preparing gene vector, high stability and bioavailability, low toxicity and the like.

This invention discloses a method for manufacturing pineapple proteinase freeze-dried powders, which can solve the problem of low activity faced by conventional pineapple proteinase. The method comprises the steps of: washing pineapple stems with water, pressing to obtain juice, filtering, adsorbing the filtrate with zinc oxide, desorbing, ultrafiltering, concentrating and freeze-drying to obtain pineapple proteinase freeze-dried powders, whose enzyme activity can reach 600 million units per gram.

One aspect of the invention contemplates a mutant E-WE thrombin precursor that contains the SEQ ID NO:1 amino acid residue sequence. Another aspect contemplates a thrombin precursor that contains the amino acid residue sequence Asp / Glu-Gly-Arg at positions 325, 326 and 327 based on the preprothrombin sequence. A third aspect contemplates a thrombin precursor that contains the SEQ ID NO:1 amino acid residue sequence as well as the amino acid residue sequence Asp / Glu Gly Arg at positions 325, 326 and 327 based on the preprothrombin sequence. Also contemplated is a composition that contains an effective amount of mutant thrombin dissolved or dispersed in a pharmaceutically acceptable carrier. A method is also disclosed for enhancing treating and preventing thrombosis in a mammal in need using that composition.

The invention discloses compounds of the general formula I and provides a preparation method of the compounds which have good antithrombotic activity, wherein, R represents CH (CH3) CH 2CH3, CH (CH3)2, CH2CH (CH3)2 , CH3, H, CH2C6H5, CH2C6H4-OH-p, indole-5-group-CH2, imidazole-4-group-CH2-, CH2CH2SCH3, CH2COCH3, CH2CH2CO2CH3, CH2CH2CO2H, CH2OH, CH (OH)CH3, CH2CH2CH2NHC(NH) NH2, CH2CONH2, CH2CH2CONH2, CH2SH, CH2CH2CH2CH2NHCBz or CH2CH2CH2CH2NH2.