Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Emulsion medicine containing n-NBP for injection and its preparation method

A technology of butylphthalide and emulsion, which is used in drug combination, emulsion delivery, blood diseases, etc., can solve problems such as kidney toxicity and hemolysis, and achieve the effects of less side effects, good curative effect and stable placement.

Inactive Publication Date: 2006-10-04
高春平
View PDF1 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

n-Butylphthalide is a light yellow or colorless viscous oily liquid at room temperature. Due to its hydrophobicity, a large amount of solubilizers are required to prepare injections, such as hydroxypropyl cyclodextrin, etc., which are used in large quantities Solubilizer, which can produce side effects such as nephrotoxicity and hemolysis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Emulsion medicine containing n-NBP for injection and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] 1. See the table below for the proportioning ratio of the component examples.

[0015]

[0016] Explanation: Substituting other substances not listed in the above-mentioned table for the test can obtain the basic effect (omitted)

[0017] 2. All are prepared according to the above-mentioned preparation method to obtain nanoemulsion or microemulsion.

[0018] Third, give a few more examples:

[0019] 1. Add 0.5g n-butylphthalide, 1.2g egg yolk phospholipid, and 0.04g oleic acid to 10g refined soybean oil, heat (60-90°C), mix until clear, and obtain n-butylphthalide containing 50mg / g oil solution. Disperse 1.2 Polom and 2.25g glycerin into water for injection to obtain a water phase, and under stirring conditions, add dropwise an oil solution of phospholipids containing n-butylphthalide to obtain an oil phase into a water phase dispersion system to prepare a crude Emulsion, add water to 100ml. The obtained crude emulsion was further emulsified by means of a homoge...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medicament for injection containing n-butylphthalide and its preparing process, wherein the constituents include (by weight parts) n-butylphthalide, oil, surface active agent, isotonic agent and water by the proportion of 1:1-100:1-50:1-20:50-70. The preparing process comprises charging the isotonic agent and water soluble surface active agent into water, thus obtaining aqueous phase mixture, then charging n-butylphthalide, surface active agent and stabilizing agent into oil, heating to 60-90 deg. C, high speed stirring and emulsifying.

Description

technical field [0001] The invention relates to the technical field of drugs for treating diseases of the cardiovascular system. technical background [0002] n-butylphthalide, also known as apigenin, is the main component of celery and its seeds. It can be obtained directly from natural plant celery seed oil, or obtained through synthesis. In Chinese patent 98125618, The application of L-butylphthalide in the preparation of antithrombotic and antiplatelet aggregation drugs is disclosed, which clearly shows that the product has the function of regulating the function of NOS-NO-Cgmp system and the metabolism of arachidonic acid in nerve cells after cerebral ischemia. In Chinese patent 93117148.2, the application of apigenin A in the preparation of drugs for the prevention and treatment of cerebral ischemia in mammals or humans is disclosed. n-Butylphthalide is a light yellow or colorless viscous oily liquid at room temperature. Due to its hydrophobicity, a large amount of so...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/365A61K9/107A61K47/44A61P9/00A61P7/02
Inventor 高春平
Owner 高春平
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com