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Emulsion medicine containing n-NBP for injection and its preparation method

A technology of butylphthalide and emulsion, which is used in drug combination, emulsion delivery, blood diseases, etc., can solve problems such as kidney toxicity and hemolysis, and achieve the effects of less side effects, good curative effect and stable placement.

Inactive Publication Date: 2006-10-04
高春平
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

n-Butylphthalide is a light yellow or colorless viscous oily liquid at room temperature. Due to its hydrophobicity, a large amount of solubilizers are required to prepare injections, such as hydroxypropyl cyclodextrin, etc., which are used in large quantities Solubilizer, which can produce side effects such as nephrotoxicity and hemolysis

Method used

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  • Emulsion medicine containing n-NBP for injection and its preparation method

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Embodiment Construction

[0014] 1. See the table below for the proportioning ratio of the component examples.

[0015]

[0016] Explanation: Substituting other substances not listed in the above-mentioned table for the test can obtain the basic effect (omitted)

[0017] 2. All are prepared according to the above-mentioned preparation method to obtain nanoemulsion or microemulsion.

[0018] Third, give a few more examples:

[0019] 1. Add 0.5g n-butylphthalide, 1.2g egg yolk phospholipid, and 0.04g oleic acid to 10g refined soybean oil, heat (60-90°C), mix until clear, and obtain n-butylphthalide containing 50mg / g oil solution. Disperse 1.2 Polom and 2.25g glycerin into water for injection to obtain a water phase, and under stirring conditions, add dropwise an oil solution of phospholipids containing n-butylphthalide to obtain an oil phase into a water phase dispersion system to prepare a crude Emulsion, add water to 100ml. The obtained crude emulsion was further emulsified by means of a homoge...

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Abstract

The invention relates to a medicament for injection containing n-butylphthalide and its preparing process, wherein the constituents include (by weight parts) n-butylphthalide, oil, surface active agent, isotonic agent and water by the proportion of 1:1-100:1-50:1-20:50-70. The preparing process comprises charging the isotonic agent and water soluble surface active agent into water, thus obtaining aqueous phase mixture, then charging n-butylphthalide, surface active agent and stabilizing agent into oil, heating to 60-90 deg. C, high speed stirring and emulsifying.

Description

technical field [0001] The invention relates to the technical field of drugs for treating diseases of the cardiovascular system. technical background [0002] n-butylphthalide, also known as apigenin, is the main component of celery and its seeds. It can be obtained directly from natural plant celery seed oil, or obtained through synthesis. In Chinese patent 98125618, The application of L-butylphthalide in the preparation of antithrombotic and antiplatelet aggregation drugs is disclosed, which clearly shows that the product has the function of regulating the function of NOS-NO-Cgmp system and the metabolism of arachidonic acid in nerve cells after cerebral ischemia. In Chinese patent 93117148.2, the application of apigenin A in the preparation of drugs for the prevention and treatment of cerebral ischemia in mammals or humans is disclosed. n-Butylphthalide is a light yellow or colorless viscous oily liquid at room temperature. Due to its hydrophobicity, a large amount of so...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K9/107A61K47/44A61P9/00A61P7/02
Inventor 高春平
Owner 高春平
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