Organ preservation solution and method for preparing same

Abstract

The invention relates to an organ preservation solution and a method for preparing the same. The method comprises the following steps of: (1) adopting double buffer pairs of citric acids and phosphates to enable the PH value of a solution to be maintained in a range of 7.5 to 8; (2) adding active ingredients such as adenosine, L-arginine, tryptophan, ligustrazine hydrochloride, reduced glutathione and the like and keep the solution stable; (3) to maintain a hypertonic property of the preservation solution with an osmotic pressure of 350-380 mOsm/L, adopting trehalose and gluconolactone as impermeable substances to effectively prevent cellular edema; and (4) adopting polyethylene glycol with a large molecular weight as a colloidal substance to effectively prevent extracellular space from expanding. Compared with the prior art, the method employs raw materials which are all homemade medicinal components and meet the standards of national pharmacopoeia, and are cheap and free of incompatibility; the organ preservation solution prepared is a colorless and transparent liquid which has stable properties, and can be sterilized by high temperature and high pressure, stored at normal temperature or low temperature, and refrigerated, and thus preparation, transportation, storage and usage of the organ preservation liquid are all very easy and convenient.

Description

technical field [0001] The invention relates to the preservation technology of human or animal organs, tissues or cells in the field of medical devices, and is an organ preservation solution for clinical organ transplantation medicine and a preparation method thereof. Background technique [0002] Organ transplantation has become the only effective cure for end-stage organ failure. High-quality donors are the prerequisite and fundamental guarantee for the success of any clinical organ transplantation. As one of the three pillars of organ transplantation, organ preservation has made significant contributions to this and is the cornerstone of organ transplantation. The fundamental purpose of organ preservation is to minimize the various damages caused by ischemia to the isolated organs, to preserve the effective vitality of the isolated organs, so as to complete the transportation, matching and operation, and to enable the transplanted organs to quickly recover their functions...

AI Technical Summary

Problems solved by technology

[0004] However, this preservation solution also has its inherent disadvantages: (1) high potassium and low sodium, which can easily cause damage to vascular endothelial cells; Aggregation of red blood

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