The invention discloses a niobium-titanium-chromium-boron alloyed wear-resistant steel. The niobium-titanium-chromium-boron alloyed wear-resistant steel comprises, by weight, 0.15-0.30% of C, 0.40% orless of Si, 0.60-1.60% of Mn, 0.015% or less of P, 0.0015% of S, 0.010-0.050% of Nb, 0.0025-0.40% of Cr, 0.010-0.040% of Ti, 0.015-0.040% of Als, 0.0025-0.040% of Ni, 0.0010-0.0040% of Cu, 0.0010-0.0050% of Ca, 0.0010-0.0030% of B, 0.006% or less of N, 0.004% or less of O, 0.00020% or less of H, and the balance of iron and inevitable impurities. A preparation method of the niobium-titanium-chromium-boron alloyed wear-resistant steel comprises the following steps: hot metal pretreatment, converter smelting, alloy fine adjustment, LF refining, RH refining, continuous casting, stacking slow cooling, hot rolling, cross cutting and flattening, and heat treatment for obtaining the finished product. The niobium-titanium-chromium-boron alloyed wear-resistant steel is a martensite structure, and has excellent mechanical properties and excellent wear resistance, the Rm value is 1250-1500 MPa, the A50 value is 7-15%, the HBW value is 425-500, the thickness size tolerance is within -0.15 to +0.15mm, and the lowest thickness of a wear-resistant plate produced from the steel can be 2.0 mm.