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Method for establishing fingerprint spectrum of volatile components of musk wind-dispelling and pain-relieving paste, standard fingerprint spectrum and application thereof

A technology of volatile components and fingerprints, applied in the field of identification of traditional Chinese medicine preparations, to achieve the effects of good solution stability and durability, quality assurance, and improved quality control level

Active Publication Date: 2020-12-11
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention intends to provide a method for establishing the fingerprint of the volatile components of the Musk Zhuifeng Zhitong Ointment, so as to solve the technical problem of lacking a quality control method for simultaneous detection of multiple volatile components of the Musk Zhuifeng Zhitong Ointment

Method used

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  • Method for establishing fingerprint spectrum of volatile components of musk wind-dispelling and pain-relieving paste, standard fingerprint spectrum and application thereof
  • Method for establishing fingerprint spectrum of volatile components of musk wind-dispelling and pain-relieving paste, standard fingerprint spectrum and application thereof
  • Method for establishing fingerprint spectrum of volatile components of musk wind-dispelling and pain-relieving paste, standard fingerprint spectrum and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: the establishment of standard fingerprint

[0041] Taking the composition of Musk Zhuifeng Zhipain Ointment (rubber plaster, approval number: Z20027408, specification: 7cm*10cm, amount of ointment (drug content) per tablet: not less than 1.12g) composition as an example, the effect on fingerprint The establishment method of the spectrum and the standard fingerprint spectrum will be explained. In this plan, the samples of Musk Zhuifeng Zhipain Ointment include the rubber plaster of Musk Zhuifeng Zhifeng Pain Cream, the gel plaster of Musk Zhuifeng Zhifeng Pain Ointment or the powdery premixed plaster of Musk Zhuifeng Zhifeng Pain Ointment. In this embodiment, the sample of Musk Zhuifeng Zhitong Ointment is a rubber plaster of Musk Zhuifeng Zhitong Ointment.

[0042] 1. Instruments and reagents

[0043] (1) Shimadzu Gas Chromatograph (GC-2014)

[0044] (2) Shimadzu electronic balance (ATY224)

[0045] (3) Musk Zhuifeng Pain Relief Ointment (self-produced...

Embodiment 2

[0055] Embodiment 2: Utilize the standard fingerprint spectrum of establishment to carry out product quality appraisal

[0056] The test sample of this embodiment is Musk Zhuifeng Pain Relief Ointment (rubber plaster, approval number: Z20027408, specification: 7cm*10cm, content of ointment: not less than 1.12g), and its preparation method is according to the publication number: Chinese patent of CN200610079120.0.

[0057] (1) Detection method: chromatographic conditions: Shimadzu gas chromatograph (GC-2014), chromatographic column: polyethylene glycol nitrobenzene is a capillary column (HP-FFAP, column length is 30m, inner diameter is 0.32mm, film thickness is 0.25μm); carrier gas: N 2 ;Column temperature: the initial temperature is 130°C, keep it for 20min, raise the temperature to 195°C at a rate of 7.5°C per minute, keep it for 20min; inlet temperature: 250°C; detector temperature: 250°C.

[0058] (2) Preparation of reference substance solution: get camphor reference subs...

Embodiment 3

[0062] Embodiment 3: Utilize the standard fingerprint spectrum of establishment to carry out product quality appraisal

[0063] The test sample in this example is Musk Zhuifeng Zhitong Ointment (powder premixed plaster), which is prepared according to the Chinese patent publication number: CN201810344858.8.

[0064] (1) Detection method: chromatographic conditions: Shimadzu gas chromatograph (GC-2014), chromatographic column: polyethylene glycol nitrobenzene is a capillary column (HP-FFAP, column length is 30m, inner diameter is 0.32mm, Film thickness is 0.25μm); Carrier gas: N2; Column temperature: initial temperature is 130°C, keep for 20min, increase temperature to 195°C at a rate of 7.5°C per minute, keep for 20min; inlet temperature: 250°C; detector temperature : 250°C.

[0065] (2) Preparation of reference substance solution: get camphor reference substance, isoborneol reference substance, borneol reference substance, menthol reference substance, pulegone reference subs...

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Abstract

The invention relates to the technical field of traditional Chinese medicine preparation identification, in particular to a method for establishing a fingerprint spectrum of volatile components of musk wind-dispelling and pain-relieving paste, a standard fingerprint spectrum and application thereof. The method comprises a reference substance solution preparation step, a test solution preparation step and a detection step. In the test solution preparation step, N, N-dimethylformamide is used as a solvent to extract volatile components in a musk wind-dispelling and pain-relieving paste sample, and a liquid phase part is taken to obtain the test solution. According to the scheme, the technical problem of lack of a quality control method for volatile components of the musk wind-dispelling andpain-relieving ointment can be solved. The standard fingerprint spectrum established by the scheme and the detection method can be applied to identification of volatile components of rubber plasters,gel plasters and powdery premixed plasters of musk wind-dispelling and pain-relieving plasters.

Description

technical field [0001] The invention relates to the technical field of identification of traditional Chinese medicine preparations, in particular to a method for establishing fingerprints of volatile components of Shexiang Zhuifengzhitong Ointment, a standard fingerprint and its application. Background technique [0002] A kind of musk chasing wind extract (raw grass aconitum, raw chuanwu, frankincense, myrrh, raw nuxychonna, clove, cinnamon, Nepeta, windproof, geranium, xiangjiapi, centella asiatica, bone fragments Tonic and artificial musk), camphor, menthol, borneol, methyl salicylate, rue extract (ruta) and belladonna extract (belladonna) is the musk chasing wind pain relieving ointment composition prepared by raw material, has good anti-inflammatory , analgesic effect, and has a significant therapeutic effect on joint pain, tenderness, unfavorable flexion and extension and morning stiffness caused by rheumatism. The applicant of the present invention applied for the in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/86
CPCG01N30/02G01N30/8675G01N2030/047
Inventor 梅勇杨莉龙涛粟冲罗磊张传辉李小辉郭娟王明杰
Owner 重庆希尔安药业有限公司
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