Curcumin preparation and its making method

Abstract

A curcumin medicine for preventing and treating cancer and cardiovascular and cerebrovascular disease includes a pre-concentrated curcumin liquid in the form of softgel and prepared from the precursor of curcumin and emulsifier and a fatty curcumin emulsion prepared from the precursor of curcumin, emulsifier, antioxidant, isotonic regulator, stabilizer, pH regulator, and the water for injection. It can also provide energy to the patient.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a curcumin preparation capable of greatly improving bioavailability and a preparation method thereof. Background technique [0002] Curcumin is the orange crystal or powder extracted and refined from the roots or rhizomes of turmeric, curcuma, and turmeric. There are three main components: 1 is curcumin (Curcumin), also known as curcumin I; 2 is demethoxycurcumin (Demethoxycurcumin), that is, curcumin II; 3 is bisdemethoxycurcumin (Bjsdemethoxycurcumin) , namely curcumin III, the three structural formulas are as follows: [0003] [0004] 1. Curcumin: R1=R2=OMe [0005] 2. demethoxyeurcumin: RI=H, R2=OMe [0006] 3. bisdemethyoxycurcumin RI=R2=H [0007] Curcumin has a wide range of pharmacological effects, and has various biological activities such as anti-inflammation, anti-oxidation, anti-coagulation, hypolipidemic, anti-atherosclerosis, anti-mutagenesis, anti-virus an...

AI Technical Summary

Problems solved by technology

[0008] Although curcumin has promising development prospects, its poor water solubility and fat solubility not only bring difficulties to the research and development of preparations, but also lead to extremely low bioavailability, which limits its clinical application

The domestic patent CN03143234.4 describes a soft capsule characterized by curcumin and vegetable oil or polyethylene glycol content. Only a small amount of curcumin can be dissolved in the above content, thereby increasing the dosage of patients; The long-chain fatty acid vegetable oil has a slow metabolism in the body and cannot reflect the advantage of improving bioavailability

[0009] Domestic patent CN200410036402.3 proposes to improve the bioavailability of curcumin in the form of simple phospholipid complex, but its effect is limited

Also CN200510042547.9 proposes the self-emulsification of curcumin, but the poor fat-soluble properties of curcumin make it only possible to dissolve in a small amount in the content, using the result of the solubilization of a large amount of emulsifier and co-emulsifier , will cause gastrointestinal irritation, and the use of co-emulsifiers in soft capsules will lead to inevitable problems such as drug migration and capsule leakage

[0010] Patent CN200310116734.8 describes the preparation method of curcumin injection and freeze-dried powder injection, which is a complex formed by curcumin and β-cyclodextrin with polyhydroxy macromolecular substance complex and freeze-dried powder for injection Composed of excipients, the patent requires a large amount of β-cyclodextrin to encapsulate curcumin. These large molecular substances enter the blood, which can easily cause allergic reactions and hemolytic reactions

[0011] There is a domestic patent CN200510035060.8 which develops the preparation of curcumin solid dispersion. Although it can improve the bioavailability to a certain extent, it has the disadvantage of easy aging, which affects its storage and is inconvenient for clinical use.

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