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Compound dispersible tablet for treating hypertension

A technology of dispersible tablets and hydrochlorothiazide, which is applied in the fields of pharmaceutical formulations, organic active ingredients, cardiovascular system diseases, etc., and can solve the problems that there is no scientific basis for the development of valsartan and hydrochlorothiazide formulations.

Active Publication Date: 2006-02-15
江苏万高药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to date, no one has provided a scientific basis for the development of dosage forms of valsartan and hydrochlorothiazide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: prescription (calculated in single tablet)

[0035] Component Content (mg / tablet)

[0036] Valsartan 320mg

[0037] Hydrochlorothiazide 12.5mg

[0038] Microcrystalline Cellulose 150mg

[0039] Mannitol 100mg

[0040] Sodium Carboxymethyl Starch 40mg

[0041] Low-substituted hydroxypropyl cellulose 10mg

[0042] Micronized silica gel 10mg

[0043] Talc powder 5mg

[0044]Stevia 5mg

[0045] 3% hypromellose in 90% ethanol solution

[0046] Total tablet weight 652.5mg

[0047] Process:

[0048] Get the raw materials of valsartan and hydrochlorothiazide, pulverize them, pass through a 200-mesh sieve, and set aside.

[0049] According to the prescription quantity, take valsartan and hydrochlorothiazide, microcrystalline cellulose, mannitol, stevioside and carboxymethyl starch sodium and mix evenly through a 100-mesh sieve, pour into the soft material made of adhesive, pass through a 40-mesh sieve to granulate, Dry at 55°C, granulate with 40 mesh, a...

Embodiment 2

[0050] Embodiment 2: prescription (calculated in single tablet)

[0051] Component Content (mg / tablet)

[0052] Valsartan 80mg

[0053] Hydrochlorothiazide 25mg

[0054] Calcium Sulfate 50mg

[0055] Microcrystalline Cellulose 100mg

[0056] Low-substituted hydroxypropyl cellulose 30mg

[0057] Micronized silica gel 5mg

[0058] Talc powder 5mg

[0059] Aspartame 5mg

[0060] 2% hypromellose in 75% ethanol solution

[0061] Total tablet weight 300mg

[0062] Process:

[0063] According to the prescription amount, weigh valsartan, hydrochlorothiazide, calcium sulfate, microcrystalline cellulose, aspartame and 3 / 4 of the prescription amount of low-substituted hydroxypropyl cellulose, pass through a 100-mesh sieve and mix evenly, pour into the adhesive Prepare soft material, granulate through 20 mesh sieve, dry at 50°C, granulate with 20 mesh, add micropowder silica gel, talcum powder and remaining low-substituted hydroxypropyl cellulose that have passed through 100 mes...

Embodiment 3

[0064] Embodiment 3: Prescription (calculated in single tablet)

[0065] Component Content (mg / tablet)

[0066] Valsartan 320mg

[0067] Hydrochlorothiazide 25mg

[0068] Mannitol 75mg

[0069] Calcium Sulfate 75mg

[0070] Carboxymethyl Starch Sodium 50mg

[0071] Low-substituted hydroxypropyl cellulose 10mg

[0072] Sodium Lauryl Sulfate 15mg

[0073] Micronized silica gel 10mg

[0074] Talc powder 10mg

[0075] Protein sugar 20mg

[0076] 5% hypromellose in 95% ethanol solution

[0077] Total tablet weight 610mg

[0078] Process:

[0079] Get the raw materials of valsartan and hydrochlorothiazide, pulverize them, pass through a 180-mesh sieve, and set aside.

[0080] According to the prescription amount, weigh valsartan, hydrochlorothiazide, mannitol, calcium sulfate, sodium starch glycolate, sodium lauryl sulfate, protein sugar, pass through a 100 mesh sieve and mix evenly, pour into soft material made of adhesive, pass Granulate with a 18-mesh sieve, dry at 6...

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PUM

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Abstract

The invention relates to a medicinal oral preparation containing Valsartan and Hydrochlorothiazide, more specifically the dispersible tablets for enhancing the beneficial effects of Valsartan and Hydrochlorothiazide.

Description

technical field [0001] The present invention relates to pharmaceutical oral formulations comprising valsartan and hydrochlorothiazide, in particular to a dispersible tablet form for enhancing the beneficial effects of valsartan and hydrochlorothiazide. Background technique [0002] Valsartan is an angiotensin II (Angiotensin II) receptor inhibitor, which can inhibit the conversion of Ang I to Ang II, and specifically antagonizes the angiotensin converting enzyme 1 receptor (AT1), and its antagonism to AT1 is 500 times greater than that of AT2 , by selectively blocking the binding of Ang II to the AT1 receptor, inhibiting vasoconstriction and the release of aldosterone, resulting in a hypotensive effect. Hydrochlorothiazide (hydrochlorothiazide, HCTZ) is a traditional antihypertensive drug and belongs to the middle-effect diuretic. Acts on the distal renal tubule to activate the renin-angiotensin system (RAS). The combined application of the two can make blood pressure more...

Claims

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Application Information

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IPC IPC(8): A61K31/549A61K9/20A61P9/12A61K31/41
Inventor 姚俊华
Owner 江苏万高药业股份有限公司
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