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Candesartan cilexetil/hydrochlorothiazide capsule and preparation method thereof

A technology of candesartan cilexetil and hydrochlorothiazide, which is applied in the field of medicine and can solve the problems such as no reports of candesartan/hydrochlorothiazide combination capsules

Inactive Publication Date: 2010-03-17
北京瑞伊人科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] According to the retrieval results of related patents and prior art documents, there are no related reports on the candesartan / hydrochlorothiazide composition capsules of the present invention and related preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] prescription:

[0054] Candesartan cilexetil 16g

[0055] Hydrochlorothiazide 12.5g

[0056] Macrogol 6000 16g

[0057] Lactose 100g

[0058] 62g pregelatinized starch

[0059] 5% hydroxypropyl methylcellulose 10g

[0060] Magnesium Stearate 0.5% 1g

[0061]

[0062] Makes 1000 capsules

[0063] Preparation Process:

[0064] Grind candesartan cilexetil, hydrochlorothiazide raw materials, pregelatinized starch, and hydroxypropyl methylcellulose, etc., pass through a 100-mesh sieve respectively, and set aside; mix hydrochlorothiazide, pregelatinized starch, and lactose evenly; use a small amount of Dissolve polyethylene glycol 6000 in water, add candesartan cilexetil for grinding, stir to form a paste, then add the well-mixed mixture and stir evenly; prepare the mixed material with a solution of 5% hydroxypropyl methylcellulose Soft material, granulated with 14 mesh sieve; dried at 50℃~60℃ until the water content is 3.5~6.5...

Embodiment 2

[0067] prescription:

[0068] Candesartan cilexetil 16g

[0069] Hydrochlorothiazide 12.5g

[0070] Macrogol 4000 12g

[0071] Microcrystalline Cellulose 65g

[0072] 100g pregelatinized starch

[0073] 5% hydroxypropyl methylcellulose 10g

[0074] Magnesium Stearate 0.5% 1g

[0075]

[0076] Makes 1000 capsules

[0077] Preparation Process:

[0078] Pulverize candesartan cilexetil and hydrochlorothiazide raw materials, pregelatinized starch, microcrystalline cellulose, and hydroxypropyl methylcellulose, etc., pass through a 100-mesh sieve respectively, and set aside; hydrochlorothiazide, pregelatinized starch, microcrystalline Mix the cellulose evenly; dissolve polyethylene glycol 4000 with a small amount of water, add candesartan cilexetil for grinding, stir to form a paste, then add the evenly mixed mixture and stir evenly; mix the mixed material with 5% hydroxypropyl The soft material is prepared from the solution of meth...

Embodiment 3

[0081] prescription:

[0082] Candesartan cilexetil 16g

[0083] Hydrochlorothiazide 12.5g

[0084] Poloxamer 16g

[0085] Lactose 62g

[0086] 100g pregelatinized starch

[0087] Ethanol 30ml

[0088] Micronized silica gel 1g

[0089]

[0090] Makes 1000 capsules

[0091] Preparation Process:

[0092] Grind candesartan cilexetil, hydrochlorothiazide raw materials, pregelatinized starch, etc., pass through a 100-mesh sieve respectively, and set aside; mix hydrochlorothiazide, pregelatinized starch, and lactose evenly; dissolve poloxamer with a small amount of water, add Grind candesartan cilexetil, stir to form a paste, then add the well-mixed mixture and stir evenly; use 60% ethanol solution for the mixed material to make a soft material, and granulate with a 14-mesh sieve; dry at 50°C to 60°C until Moisture content is 3.5-6.5%. Sieve through a 14-mesh sieve, add micro-powdered silica gel and mix evenly, and send to test the c...

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PUM

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Abstract

The invention provides a candesartan / hydrochlorothiazide capsule and a preparation method thereof. The invention has the obvious advantages as follows: on the one hand, the invention can obviously reduce the blood pressure of a hypertensive patient, effectively protect the heart, the brain and the kidney organ and reduce the incidence of complications and has safety, effectiveness, high tolerance,and the like; on the other hand, the invention also has the advantages of less tablet process link, short production period, less quality control points of production process, and the like besides keeping the advantages of accurate dosage, convenient application, stable quality, convenience for carrying, transport and storage, high degree of production mechanization and automatization, large yield, and the like of the prior tablet / dispersible tablet and can simplify the industrial production, thereby being beneficial to the reduction of drug production and management costs and the selection of doctors and patients for cheap and good drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a candesartan / hydrochlorothiazide capsule and a preparation method thereof. Background technique [0002] Since the treatment of hypertensive diseases is long-term, it is advisable to choose drugs with mild effects and fewer adverse reactions. At present, it is believed that the purpose of hypertension treatment is to prevent and reduce the damage of target organs and prolong life, so it is required to lower blood pressure to a certain low level and maintain this level. In order to meet this requirement, a single antihypertensive drug cannot meet the clinical treatment requirements, so two or more drugs need to be used in combination. The most commonly used clinical treatment of hypertension is the combination of diuretics and beta-receptor blockers, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, etc. [0003] Candesartan cilexetil / hydrochlorothiazide c...

Claims

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Application Information

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IPC IPC(8): A61K31/4184A61K31/5415A61K9/48A61P9/12
Inventor 张玲玲安英张慧英
Owner 北京瑞伊人科技发展有限公司
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