230 results about "Drug production" patented technology

The invention discloses a method for preparing a D, L-2-hydroxyl-4-methylthio butanoic calcium salt for medicinal purpose. The method comprises following steps of: a. using a D,L-2-hydroxyl-4-methylthio butanoic acid and an alcohol with a general formula of ROH as the raw materials to carry out esterification to obtain a D, L-2-hydroxyl-4-methylthio butyrate, and; b. hydrolyzing the D, L-2-hydroxyl-4-methylthio butyrate in step a and calcium oxide in a solvent to produce the D, L-2-hydroxyl-4-methylthio butanoic calcium salt. The method provided by the invention for the production of the D, L-2-hydroxyl-4-methylthio butanoic calcium salt has the advantages of short course, readily available the raw materials, low cost, easy control over the quality of the product, and more importantly, the method can prepare high-purity D, L-2-hydroxyl-4-methylthio butanoic calcium salt for medicinal purpose, thereby satisfying the requirements of State Food and Drug Administration Bureau and Good Manufacturing Practice (GMP) for drug production, and facilitating the preparation of pharmaceutical preparations.

The invention discloses a novel Bifidobacterium breve with excellent probiotic function. The Bifidobacterium breve strains are obtained by screening the feces of the long-lived elders in Hetian, XinJiang, and the obtained strains have outstanding resistance to acid and bile acid salts, adhesion characteristics to intestinal tract epidermic cells, excellent antibacterial performance and good oxidization resistance; and the strains have an effect on reducing the blood pressure as well as the edible safety, therefore, the Bifidobacterium breve can be widely applied in the fields such as functional additives, dairy products, beverage, functional food, drug production, etc.

A system and method for determining an optimal combination drug product for a particular patient includes a processor that receives patient information and determines an optimal combination drug product based on the received information. A system which can provide information regarding predicted events or pathologies based on received patient information and guidance on subsequent steps to ameliorate, treat or intervent. A drug production device includes a plurality of drug containers, each of which are coupled to a drug dispensing channel. A controller controls the dispensing of drug through each channel, and a combination drug product is produced from the dispensed drugs. A combination drug product includes a plurality of discrete units of a first drug, and a plurality of discrete units of a second drug.; A transdermal patch includes a plurality of drug compartments, each containing a quantity of drug product, and a controller for controlling the release of drugs from each compartment. Feedback loop elements can enable iterations to optimized personalized doses.

Glossy ganoderma as a traditional Chinese medicine is called immortal grass since ancient times and known as the ability to treat various diseases; a pair of lingzhiol A optical enantiomers is purified from ganoderma lucidum, and the lingzhiol A optical enantiomers have obvious effects on inhibiting rat renal mesangial cell strains induced by high glucose to generate reactive oxide species, IL-6, fibronectin and IV type collagen, and also can obviously inhibit the phosphorylation of the renal tubular epithelial cell Smad3 induced by TGF-beta1, so that the application prospect of the compound in preparation of medicines for treating diabetic nephropathy and chronic nephropathy is shown.

The invention discloses a block chain-based drug traceability method and device and a medium. The block chain-based drug traceability method comprises the steps: auditing a to-be-uploaded intelligentcontract, and sending the to-be-uploaded intelligent contract passing the auditing to each node to form a drug traceability intelligent contract; obtaining drug information, associating the drug information with the drug traceability code, and uploading the drug information to the drug traceability block chain; receiving an access instruction and obtaining the drug information on the drug traceability block chain according to the drug traceability intelligent contract, wherein the access instruction comprises identifying the drug traceability code; and pushing the acquired drug information toan access terminal. The drug traceability block chain related to the drug traceability method is is tamper-proof and can retain the uniqueness of the drug information and the detection certificates and can accurately and quickly provide data such as materials in different states in the drug production, circulation and detection process to consumers in real time so as to realize the tracing of thewhole drug production process.

The present invention takes chiral phosphate as catalyst, uses sulfonyl imide and indole compounds synthesize 3-methylamino-indole compound of high-efficiency and high enantioselectivity. Compared with the existing method, it can be applied to many different types of indole and sulfonyl imide compounds, mild reaction conditions, simple operation. In addition, the reaction without joining any metal salts compounds, so useful for drug production and processing. And the reaction yields are better, high enantioselectivity.

The invention provides a method for effectively synthesizing a 4,6-substituted 3,-4-dihydro-pyran-2one derivative by efficiently synthesizing aldehyde-substituted cyclopropane compound with N-heterocyclic carbene as a catalyst. Compared with the existing method, the method has the advantages of wide suitable substrate range, convenient catalyst acquisition, mild reaction condition, simple operation, and high reaction efficiency. The method is performed without any metallic salt compounds, which is good for drug production and treatment.

The invention relates to a verification method of low pH incubation virus inactivation. The method comprises the steps of selecting indicator viruses and corresponding host cells; amplifying and purifying the indicator viruses; titering virus working primary liquid and samples; optimizing the pH value of virus inactivation verification experiments; estimating the low pH incubation virus inactivation effect. By means of the method, the full process of genetically engineered drug production technology virus inactivation can be simulated in a laboratory, and the amplifying and purifying technology of the indicator viruses is optimized, so that the titer of the working primary liquid of the indicator viruses is increased, the pH value is unified to 7.0, the quality is stable, and subsequent operation is facilitated; meanwhile, the specific technological details like the determination of the optimal incubation pH value and the optimization of the pH adjusting mode of low pH incubation are optimized, and the efficiency and the effectiveness of the inactivation of common DNA viruses, RNA viruses, enveloped viruses and non-enveloped viruses are improved.

The invention belongs to the technical field of anti-inflammatory drug production, and relates to a method for preparing mefenamic acid. The method comprises: adding o-chlorobenzoic acid and 2,3-dimethylaniline into a system which is formed by a non-protonic polar solvent and a dehydrant, performing condensation reaction in the presence of an acid-binding agent, a catalyst and a phase-transfer catalyst, and obtaining mefenamic sodium; acidifying the mefenamic sodium and obtaining coarse mefenamic acid products; and refining the coarse mefenamic acid products in an organic solvent and water and obtaining finished mefenamic acid products. The method improves the production efficiency of the mefenamic acid and reduces the production cost of the mefenamic acid.

The invention discloses a gingko snail killing microemulsion agent and a preparing method, which relates to the technical field of plant source agricultural drug production. The invention takes the seed shell extract of the gingko containing a ginkgoic acid as the source drug, and the invention is made by configuring auxiliary surface active agents, solution agent and antifreeze agent as well as water. The producing method comprises the following operating steps: the gingko external seed shell extract, the microemulsion agent and the solution agent are blended to be an even and transparent oil phase; the steamed water or the deionized water are added slowly to form an oil enclosed water type emulsion during the agitating process; through agitating and heating, the emulsion is rapidly converted into a water enclosed oil type; a steady O or W type emulsion after being cooled to reach the constant indoor temperature is obtained. The invention has fine environmental compatibility of the emulsion conformation, also completely realizes the advantages of the gingko snail killing agent with high efficiency to the snail and safety to people and animals. The microemulsion agent takes water as the main solvent with slight influence to environment. In addition, the invention has remarkable synergism; the LC 50 and LC 90 of the 24h respectively are 0.56mg per liter and 3.5mg per liter, which are obviously better than that of the 24h snail killing effect (LC50 is equal to 1.35mg per liter and the LC90 is equal to 3.85mg per liter) of the external seed shell extract of the original drug.

A system and method for the simulation and modeling of biopharmaceutical batch process manufacturing facilities using process time lines is described herein. The system employs an eleven-field delimited string code which specifies the unit identifier code and the iteration value for each of the ten levels of nested scheduling cycles of the biopharmaceutical drug production process being modeled. The method includes generating a process time line using operational parameters, a block flow diagram, and a set of scheduling cycles for each of a sequence of unit operations. The process time line is used as a tool for batch processing and facility design.

The invention discloses a food and drug supervision system and method based on gridding management. The supervision system comprises a cloud computing platform, a database platform, a gridding management platform and a mobile terminal user application platform, the gridding management platform is used for dividing the supervision range into grids, and food and drug production and circulation information of all supervision enterprises in the grids is marked on a geographic map information module (GIS); The supervision method comprises the steps of administrative supervision, technical supervision and inspection case handling, and inspection case handling comprises the steps of grid division, information collection, task providing, task dispatching, task processing, processing feedback, casechecking and checking and comprehensive evaluation. According to the invention, a food safety supervision system based on a GIS professional map for prevention is established, food and drug safety production and circulation process supervision are realized, and food and drug quality safety is guaranteed.

The invention relates to the technical field of radiopharmaceutical production equipment, in particular to a dynamic calibration system for radiopharmaceutical radionuclide activity. The invention provides the dynamic calibration system for the radiopharmaceutical radionuclide activity. The dynamic calibration system comprises a radiopharmaceutical basic data module, a production management system, a warehouse management system and a logistics distribution system, wherein the production management system, the warehouse management system and the logistics distribution system respectively carry out two-way signal transmission with a radiopharmaceutical management module, the system also comprises a radiopharmaceutical radionuclide activity operation module which respectively carries out data transmission with the radiopharmaceutical management module and the radiopharmaceutical basic data module, and the radiopharmaceutical radionuclide activity operation module is respectively connected with a radiopharmaceutical inquiry module and a radiopharmaceutical medicine input/output module. The dynamic calibration system has the advantages that in a nuclear drug production management system, a radionuclide activity automatic calibration module is added, a radionuclide database is built, production materials and products of the radiopharmaceutical are realized, and the activity value at any moment can be inquired through the real-time calculation from initial parameters by inputting a product name or a chemical formula.

The invention relates to a drug production process tracing system based on the block chain technology, which includes a data acquisition unit, an inspection unit, an infrared monitoring unit, an operation monitoring unit, an environment monitoring unit and a data analysis unit. The functions of the units are clear. The materials in different states and other data in the production process can be offered to the drug production management personnel in real time, accurately and quickly. The whole drug production process can be traced.

The invention discloses a micro liquid metering ceramic pump for drug production, and belongs to the technical field of metering pumps. The ceramic pump comprises a driving section and a pump head, wherein the center of the driving section is connected with an output shaft of a stepping motor; a self-aligning roller bearing is arranged on an inner side wall of a cavity of the driving section; a cylinder body is arranged in the pump head in a sleeving manner; a liquid inlet and a liquid outlet which are corresponding mutually are formed in the cylinder body; a plunger capable of rotating and sliding relatively is arranged in the cylinder body in a matching manner; an opening is formed at the inner end of the plunger; the outer end of the plunger extends out of the cylinder body; a plunger sleeve is arranged at the outer end of the plunger, and connected with a plunger pin perpendicular to the plunger sleeve; the plunger pin is connected with the self-aligning roller bearing from the inner side of the cavity of the driving section, so that the plunger can be obliquely arranged relative to the driving section; and an included angle a between a central line of the plunger and a central line of the driving section is 0-12 degrees. According to the micro liquid metering ceramic pump for the drug production, a valveless structure effectively solves the common problems of a general metering pump, such as blocking and seizure.

The invention provides a preparation method for high purity L-calcium levofolinate. With folic acid as a starting raw material, the method relates to reduction, formylation, intermediate recrystallization splitting, hydrolysis ring opening, recrystallization refining and other steps. The L-calcium levofolinate prepared by the invention has a color ranging from white to light yellow, optical purity of not less than 98.5%, in related substance inspection, the total impurities are not greater than 1% and a single impurity is not greater than 0.3%. The preparation method for high purity L-calcium levofolinate provided by the invention has the advantages of simple operation, short process period and high product quality, and can be used for industrialized production of related bulk drugs by drug production enterprises.

The invention discloses a vegetable insecticide and relates to the field of agricultural drug production. The vegetable insecticide comprises, by weight, 8-12 parts of sophora flavescens, 15-25 parts of pepper leaves, 10-25 parts of tobacco leaves, 20-35 parts of argy wormwood, 15-30 parts of oleander leaves, 15-20 parts of pericarpium citri reticulatae, 15-25 parts of radix glycyrrhizae and 5-8 parts of spreader. The vegetable insecticide is simple in process, convenient to operate, capable of realizing broad-spectrum insect killing, strong in contact killing, safe and reliable to use, nonhazardous to human and livestock, free of residue, free of environmental pollution and reliable in efficacy, Chinese medicinal herbs resources are fully excavated and utilized, production cost is lowered greatly, insects do not produce antibodies, and continuous use can be realized.

The invention discloses an ebullated dryer for preparing hydrotalcite chewable tablets and a production process of hydrotalcite chewable tablets. The production process of the hydrotalcite chewable tablets comprises the following steps of weighing, mixing, wet granulation, drying and tabletting. The production process of the hydrotalcite chewable tablets is simple and convenient, and has simple operation. The ebullated dryer for preparing the hydrotalcite chewable tablets has the function of automatically controlling a drying endpoint, is simple in device, low in cost, accurate in detection and high in automation degree, and meets the requirement of modern drug production on automation.

The invention discloses a logistics conveying system. The logistics conveying system comprises a first conveying rail, a transition conveying rail, a second conveying rail and a packing material recycling rail; the first conveying rail is arranged on one side of the transition conveying rail, and the second conveying rail and the packing material recycling rail are arranged on the other side of the transition conveying rail; the transition conveying rail comprises an upper-layer conveying rail and a lower-layer conveying rail which are vertically arranged in parallel, the first conveying rail is connected with the upper-layer conveying rail in a butt-joint manner, the second conveying rail is connected with the upper-layer conveying rail in a butt-joint manner, and the packing material recycling rail is connected with the lower-layer conveying rail in a butt-joint manner; the first conveying rail is provided with unboxing stations, the second conveying rail is provided with unpacking stations, and the packing material recycling rail is used for receiving packing materials unpacked on the unpacking stations. The logistics conveying system has the advantages that layout is reasonable, the structure is compact, the space utilization rate of a plant area is increased, and automation of a drug production line can be achieved.