53 results about "Fosaprepitant dimeglumine" patented technology

The invention provides a sterile lyophilized preparation containing fosaprepitant, and a preparation method thereof. According to the invention, an effective dosage of fosaprepitant dimeglumine is adopted as an effective component, and auxiliary materials such as a solubilizer, a complexing agent, a lyophilization excipient, and an acidity adjusting agent are contained in the preparation. The lyophilization excipient does not comprise lactose, and is selected from one or a combination of mannitol, glucose, dextran, sorbitol, arginine, and glycine. The components are dissolved in injection water. The solution is sterilized, filtered, sub-packaged, and lyophilized. The prepared sterile lyophilized preparation has excellent high-temperature stability, illumination stability, and accelerated-experiment stability. When in use, the sterile lyophilized preparation provided by the invention is added into a solvent, so that an injection solution with an appropriate concentration is prepared and can be used. The preparation has good treatment effect upon chemotherapy-induced nausea and vomiting. With the form of injection medication, patient compliance is improved. The preparation process of the lyophilized preparation is simple. The lyophilized preparation is suitable for industrialized productions.

The invention relates to a fosaprepitant dimeglumine composition for injection and a preparation method thereof, the pharmaceutical composition is composed of fosaprepitant dimeglumine, 15-polyethylene glycol hydroxystearate and sodium calcium edentate, prescription is simple, technology is simple, and the prepared product has the advantages of stable quality, safety and reliability.

The invention discloses detection methods of a fosaprepitant dimeglumine raw material or preparation and an impurity in fosaprepitant dimeglumine raw material or preparation. According to the detection methods, a sample solution of the fosaprepitant dimeglumine raw material or preparation is detected and analyzed by using high efficiency liquid chromatography; an immobile phase of a chromatographic column used for detection is octadecyl silane bonded silica gel; a mobile phase comprises a mobile phase A and a mobile phase B, wherein the mobile phase A contains a phosphate buffer solution; themobile phase B contains acetonitrile; the gradient elution is carried out on the sample solution of the fosaprepitant dimeglumine raw material or preparation within 0 to 50min by the mobile phase A and the mobile phase B. The detection methods are simple and convenient to operate, easy to control and low in detection cost, and can be used for effectively monitoring the impurity in a fosaprepitantdimeglumine drug and accurately measuring the content of the impurity.