35results about How to "Slow disintegration" patented technology

The invention relates to a two-stage pressure atomizer nozzle with a nozzle body (30) having a mixing chamber (39) which is connected to an outside space via a nozzle outlet bore (33), and with a first feed duct (42) with a feed bore (41) for a liquid (37) to be atomized, through which feed bore said liquid (37) can be fed, free of swirling and under pressure, at least one further feed duct (36) for a portion of the liquid (37) to be atomized or for a second liquid (37') to be atomized opening into the chamber (39), through which feed duct said liquid (37, 37') can be fed under pressure and with swirling. The feed bore (41) of the first feed duct (42) lies on one axis (34) with the nozzle outlet bore (33). It is defined in that the outlet-side diameter (da) of the nozzle outlet bore (33) is at most as large as the diameter (dz) of the feed bore (41) and the length (L) of the nozzle outlet bore (33) is at least twice to at most ten times the outlet-side diameter (da) of the nozzle outlet bore (33).

A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. The hydrogel may be used as biocompatible viscoelastic filler for implant applications. Both the hydrogel and nonwoven materials are also suitable for use as tissue engineering scaffolds.

A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. Another use for the hydrogel is as a biocompatible viscoelastic filler for implant applications.

The effervescent health beverage table is featured by that it contains functional oligosaccharide, such as oligo-xylose, oligo-fructose, oligo-galactose, oligo-isomaltose, etc., with bifidobacterium proleferating function and may contain medicine, vitamins, minerals, soluble chitin and other functional factors. The tablet is produced through sieving, mixing, drying at 55-65 deg.c and tableting. The effervescent health beverage tablet, when being thrown into water, will be dissolved instantly into homogeneous beverage, health liquid, medicated tea, etc. while producing bubbles and turning up and down.

A process for the production of a fermenting material which includes the steps of forming a dough by adding water to a dried gluten in an amount of from at least 19% to 60% by weight, pelletizing the dough to form pellets, and sterilizing the pellets by steam treatment. The gluten may be rice gluten, corn gluten, wheat gluten or combinations thereof. Also, a fermenting material obtained by this process. This fermenting material can be inoculated with a microorganism and fermented to form a fermention product that can be used as a food sauce, flavoring or seasoning additive.

The invention relates to an Entecavir dispersible tablet for treating hepatitis B and process for its preparation by using Entecavir as raw material, charging auxiliary materials of specific species and proportions, and preparing tablet through the conventional techniques in the pharmaceutical industry.

Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable dosage forms.

The invention relates to an Entecavir soft capsule for treating hepatitis B and process for its preparation, by using Entecavir as raw material, charging auxiliary materials of specific species and proportions, and preparing soft capsule through the conventional techniques in the pharmaceutical industry.

This invention provides small-sized, intrabuccally rapidly disintegrating tablets comprising D-mannitol having an average particle diameter of 31 μm to 80 μm, an active ingredient, a disintegrant and stearic acid or a metallic stearate of 0.01% by weight to 0.5% by weight, which have sufficient hardness, do not disintegrate during usual handling, and have a good disintegrability in the oral cavity and a pleasant feeling in a mouth when administered, and further provides a method for producing an intrabuccally rapidly disintegrating tablet containing stearic acid or a metallic stearate in an amount of 0.01% by weight to 0.5% by weight, which comprises consecutively tableting a powder material containing D-mannitol having an average particle diameter of 31 μm to 80 μm, an active ingredient and a disintegrant by an external lubricating compression method, during which stearic acid or a metallic stearate as a lubricant is previously sprayed to adhere onto the punches and the dies of the tableting machine and the unadherent surplus of stearic acid or a metallic stearate is recovered.

The present invention provides aminopyrimidine compounds of formula (I) and their salts, wherein R1, R2, R3, R4, R5, R6, Q, Z, L, m, n are defined as the description, the methods for preparation thereof, the uses thereof and the pharmaceutical compositions comprising the effective amount of compounds of formula (I). The compounds of formula (I) and their salts can be used as protein kinase inhibitors.

Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable tablet dosage forms. Also provided is packaging that discourages the use of rapidly bioavailable acute pain medications for off-label chronic pain treatment, and that allows such dosage forms to be manufactured and stored for prolonged periods of time.

The present invention provides aminopyrimidine compounds of formula (I) and their salts, wherein R1, R2, R3, R4, R5, R6, Q, Z, L, m, n are defined as the description, the methods for preparation thereof, the uses thereof and the pharmaceutical compositions comprising the effective amount of compounds of formula (I). The compounds of formula (I) and their salts can be used as protein kinase inhibitors.

Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable dosage forms.

The invention relates to gabapentin mecobalamin dispersion tablets for treating peripheral nervous diseases such as psychalgia syndrome, etc. and a preparation method thereof, and aims to make up the disadvantages in the prior art and provide a novel preparation, i.e. the gabapentin mecobalamin dispersion tablets to patients and medical workers; wherein, the gabapentin mecobalamin dispersion tablets have swift disintegration, fast absorption and easy administration, can increase the bioavailability and the blood concentration of drugs, and increase the abirritation. Gabapentin mecobalamin is used as a raw material, auxiliary materials with specific types and proportions are added in, and the mixture is pressed into tablets according to the conventional technique of the preparation course.

The invention relates to an Entecavir drop pill for treating hepatitis B and process for its preparation by using Entecavir as raw material, charging auxiliary materials of specific species and proportions, and preparing drop pills through the conventional techniques in the pharmaceutical industry.

The present invention relates to a new type medicine preparation memantine hydrochloride dispersing tablet and its preparation method. Its composition includes (by wt%) 0.5-95% of memantine hydrochloride, 20-90% of filling agent, 5-30% of disintegrant agent, 1-30% of corrective agent, 0.1-5% of lubricating agent and 0.5-5% of metarchon agent.

The invention relates to compound domperidone dimeticone dispersion tablets for treating the gaseous distention of gastrointestinal tract caused by indigestion and a preparation method thereof, and aims to make up the disadvantages in the prior art and provide a novel compound preparation, i.e. compound domperidone dimeticone dispersion tablets to patients and medical workers; wherein, the compound domperidone dimeticone dispersion tablets have swift disintegration, fast absorption and easy administration, and can increase the bioavailability and the blood concentration of drugs. Domperidone dimeticone is used as a raw material, auxiliary materials with specific types and proportions are added, and the mixture is pressed into the tablets according to the conventional technique of the preparation course.

A track bed composite structural element issued in railway track engineering, and has an upper water permeable layer, a lower water permeable layer and a filter material layer provided between the upper and lower water permeable layers. The upper and lower layers may comprise geotextile layers and the filter material may be sand or glass, for example.

The invention discloses a traditional Chinese medicine composition with the scalp inflammation-relieving and itching-relieving effects and a preparation method thereof. The traditional Chinese medicine composition comprises the components including first essential oil, second essential oil, a herba centellae extracting solution, chitosan, glucolactone and the like; the first essential oil is essential oil prepared from pine needles and coriander through supercritical CO2 extraction; and the agilawood essential oil (the second essential oil) is obtained through extraction with the supercriticalCO2 extraction technology, ethyl acetate is adopted as an entrainer during extraction, and meanwhile, agilawood is pretreated after being smashed before extraction, so that the extraction rate of theagilawood essential oil can be effectively increased. According to the traditional Chinese medicine composition with the scalp inflammation-relieving and itching-relieving effects and the preparationmethod thereof, the process design is reasonable, the operation is simple, the prepared traditional Chinese medicine composition not only has excellent inflammation diminishing, itching relieving, antibacterial and bacteriostatic effects, but also can be used for scalp inflammation treatment, the traditional Chinese medicine composition is relatively good in component stability, and a medicine has a long-acting slow-release effect. In actual use, the effect is better, and the practicability is relatively high.

The invention provides a pelvic inflammation treating tablet and a preparation method thereof, and belongs to the technical field of medicines. The pelvic inflammation treating tablet comprises the following auxiliary materials by weight percent according to the total weight of the tablet: 10-35% of lactose, 1-3% of sodium carboxymethyl starch, 2-5% of microcrystalline cellulose, 0.5-2% of superfine silica powder and 6-15% of medicinal ethanol. Undissolved tablets of traditional Chinese medicine tablets are changed into soluble tablets and instant tablets, so that the problems that all extract tablets of the traditional Chinese medicine are slow to disintegrate and slow to take effect are fundamentally solved, the bioavailability of the traditional Chinese medicine product is improved, and the clinical curative effect of the product is enhanced. The novel medicinal auxiliary materials are refined, and the components are scientific, so that the disintegration time limit of the product is accelerated by 3-4 times on the original basis, the dissolution rate of effective components in the product is increased, and the inherent quality of the traditional Chinese medicine tablet is greatly improved.

Provided are rapidly bioavailable solid oral dosage forms of acute pain medications, and moisture resistant packaging that enables the formulation of such rapidly bioavailable dosage forms.

A dripping pill of miglinar for treating hepatitis B and its preparing process are disclosed. Its advantages are high disintegrating speed and biologic utilization rate, and simple preparing process.

The invention discloses a method for processing a condensed pill for treating eye disease. Medicinal prescription of 3000 condensed pills comprises the following components of 10-15g of pearl powder from bred mussels, 15-20g of cloud notoginseng powder, 5-10g of fructus viticis, 8-10g of selfheal spike, 8-10g of angelica sinensis, 5-10g of ligusticum wallichii and the like. The product pill is prepared by the processes of decocting crude drugs, crushing raw materials, refining old honey and the like. The vision of a sufferer can be effectively improved; muscae volitantes and clumps ghosting of the affected eye caused by vitreous opacities can be removed; middle concurrency cataracts caused by lens opaque can be effectively reversed; bulbi hypertonia of the affected eye caused by secondary glaucoma can be reversely reduced to within a normal value of 10-21mmHg; and the pain of the sufferer during extraction eyeball by a western medicine surgery is removed. Therefore, the medical problem that difficult eye diseases cannot be solved by western medicine at present is overcome.

The invention discloses a Mongolian medicine for treating osteoporosis and rheumatism. The Mongolian medicine is water-honeyed pills prepared from the following traditional Chinese medicine raw materials in parts by weight: 2-10 parts of sapanwood, 1-3 parts of areca catechu seeds, 1-3 parts of galanga, 0.5-2 parts of tsaoko amomum fruits, 0.5-2 parts of costus roots, 1-3 parts of amomum cardamomum, 1-5 parts of radix asparagi, 1-5 parts of gymnadenia conopsea, 1-5 parts of rhizoma polygonati, 1-5 parts of semen myristicae, 1-5 parts of eugenia caryophyllata and 1-5 parts of syringa pinnatifolia roots or stems. According to the Mongolian medicine disclosed by the invention, various traditional Chinese medicines are reasonable in compatibility, not only have components capable of tonifyingthe liver and the kidney, strengthening the bones and muscles and improving the immune competence of organisms but also have components capable of eliminating dampness, relieving a pain, inducing diuresis for removing edema, relieving exterior syndromes and dispelling cold, so that the purpose of comprehensively and integrally conditioning bodies and treating both manifestation and root cause of adisease can be achieved. The water-honeyed pills disclosed by the invention are delicate in nature, moderate in effects, suitable for patients suffering from chronic diseases of osteoporosis and rheumatism to use, and convenient to carry and take.

The invention discloses child stomach harmonizing pills which comprise rhizoma atractylodis, cortex magnoliae officinalis, fructus hordei germinatus, hawthorn fruits, fructus amomi, radix aucklandiae, herba schizonepetae, patchouli, rheum officinale, caulis clematidis armandii, radices trichosanthis, borneol, pericarpium citri reticulatae, rhizoma pinelliae preparata, fructus aurantii, coptis, liquorice, platycodon grandiflorum, cinnabar and refined honey. The child stomach harmonizing pills adopt a pure traditional Chinese medicine formula, and is little in side effect; the honeyed pills have the characteristics of soft and moist texture, slowness in absorption and mild effect, and are extremely suitable for child patients; and the preparation method of the child stomach harmonizing pills is simple, convenient, quick, safe and controllable, and is suitable for industrial production.

The invention relates to a dropping pill with fentanyl as a main active component and a preparation method thereof. The dropping pill adopts the fentanyl and salts or hydrates which can be accepted in terms of pharmacy as the active components. The invention aims at providing a new preparation namely the fentanyl dropping pill for vast patients and medical workers. The fentanyl dropping pill has the following characteristics: the disintegration is quick, the bioavailability of the pill can be enhanced, the curative effect of the pill can be completely exerted, and adverse reactions can be reduced; the fentanyl dropping pill is convenient not only for children to take, but also for old people to take with reduced dosage; the preparation method is simple; in addition, the fentanyl dropping pill is suitable for mass production and is convenient for carrying, storing as well as transporting. The fentanyl and the salts or the hydrates which can be accepted in terms of pharmacy are adopted as the active components and some accessories of specified categories and in specified proportions are added, so as to prepare the dropping pill according to the conventional technology in terms of pharmaceutics.

The invention discloses a traditional Chinese medicine composition for treating rheumatalgia. The traditional Chinese medicine composition is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-30 parts of suberect spatholobus stems, 10-30 parts of honeysuckle stems, 10-30 parts of herba aristolochiae, 5-15 parts of angelica sinensis, 10-20 parts of cocculus orbiculatus, 10-20 parts of radix rehmanniae, 10-30 parts of fructus cannabis, 10-30 parts of radix angelicae pubescentis, 10-30 parts of bunge cherry seeds, 5-15 parts of fructus aurantii, 10-30 parts of notopterygium roots, 10-30 parts of corydalis tuber and 5-15 parts of safflower. The traditional Chinese medicine composition is reasonable in formula, wide in raw material source of traditional Chinese medicines used in the formula, low in cost and suitable for patients suffering from chronic diseases such as rheumatalgia and the like.