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Entecavir dripping pills and method for preparing the same

A technology of entecavir and entecavir, which is applied in the field of entecavir dripping pills for treating hepatitis B and its preparation field, can solve the problems of multi-pharmaceutical factories, government departments, scientific research institutes and other institutions that are conducting research work on the drug and the like.

Inactive Publication Date: 2006-02-15
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no dosage form of Entecavir on the market in the domestic market, but many pharmaceutical companies, government departments, scientific research institutes and other institutions are conducting research on this drug

Method used

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  • Entecavir dripping pills and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] prescription:

[0021] Entecavir 5g

[0022] PEG4000 45g

[0023] PEG6000 250g

[0024] A total of 10000 capsules were made

[0025] Preparation:

[0026] Take Entecavir, PEG4000, and PEG6000 and mix them evenly, heat them in a water bath to melt them completely to obtain a molten liquid; then pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, select the dripper, and drop it into - In simethicone oil at 5°C, after molding, filter, separate, and wipe clean to obtain.

Embodiment 2

[0028] prescription:

[0029] Entecavir 1g

[0030] PEG6000 125g

[0031] Polyoxyl 40 Stearate 24g

[0032] A total of 10000 capsules were made

[0033] Preparation:

[0034] Mix entecavir, PEG6000, and polyoxyl 40 stearate evenly, heat in a water bath to melt completely to obtain a molten liquid; then pour the molten liquid into the material funnel of the dropping pill making machine, keep it warm at 80°C, and select the Head, drop into simethicone oil at -5°C, after forming, filter, separate, wipe clean, that is to say.

Embodiment 3

[0036] prescription:

[0037] Entecavir 1g

[0038] Polyoxyl 40 Stearate 244g

[0039] A total of 10000 capsules were made

[0040] Preparation:

[0041] After mixing entecavir and polyoxyl 40 stearate evenly, heat in a water bath to completely melt to obtain a molten liquid; then pour the molten liquid into the material funnel of the dropping pill dripping machine, keep it warm at 80°C, select the dripper, Drop it into liquid paraffin at -5°C, and after it is formed, filter, separate, and wipe it clean.

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Abstract

The invention relates to an Entecavir drop pill for treating hepatitis B and process for its preparation by using Entecavir as raw material, charging auxiliary materials of specific species and proportions, and preparing drop pills through the conventional techniques in the pharmaceutical industry.

Description

technical field [0001] The invention relates to a novel pharmaceutical preparation, in particular to entecavir dropping pills for treating hepatitis B and a preparation method thereof. Background technique [0002] The morbidity and mortality caused by hepatitis B virus ((HBV) in the world is the most serious among liver viruses. According to the statistics of the World Health Organization, there are about 350 million HBV carriers in the world, causing about 100-200 deaths per year At present, there are two kinds of serum vaccines and DNA recombinant vaccines for prophylaxis; and what is commonly used for therapeutic drugs is alpha-interferon, which is not only expensive and difficult to tolerate, but also has low effective rate (only 25%-40 % of patients had remission). [0003] Entecavir (entecavir) is epoxy hydroxycarbodeoxyguanosine, a deoxyguanosine analogue that can effectively inhibit the replication of hepatitis B virus, and has a strong anti-HBV effect. The chemic...

Claims

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Application Information

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IPC IPC(8): A61P1/16A61K31/522A61K9/20A61P31/20
Inventor 严轶东
Owner FUKANGREN BIO PHARMA
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