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Compound gabapentin mecobalamin dispersible tables and preparation method thereof

A technology of gabapentin methylcobalamin and gabapentin methylcobalamin, which is applied in the field of new pharmaceutical preparations and can solve problems such as the research work of the medicine being carried out by government departments, scientific research institutes and other institutions

Inactive Publication Date: 2008-11-19
北京利乐生制药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no dosage form of gabapentin mecobalamin on the market in the domestic market, but many pharmaceutical companies, government departments, scientific research institutes and other institutions are conducting research on this drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023] Gabapentin 300g

[0024] Methylcobalamin 0.5g

[0025] Mannitol 25g

[0026] Microcrystalline Cellulose 137.5g

[0027] Croscarmell Starch Sodium 19g

[0028] Cross-linked polyvinylpyrrolidone 8g

[0029] Starch slurry 7g (calculated as starch)

[0030] Magnesium Stearate 3g

[0031] A total of 1000 pieces were made

[0032] Preparation:

[0033] First, the above-mentioned materials were crushed through a 100-mesh sieve, and after the gabapentin, methylcobalamin, mannitol, and microcrystalline cellulose were thoroughly mixed, an appropriate amount of starch slurry was added to make a soft material, granulated with a 16-mesh sieve, and 60°C After drying for 3-4 hours, granulate with a 16-mesh sieve, add disintegrant cross-linked carboxymethyl starch sodium, cross-linked polyvinylpyrrolidone and lubricant magnesium stearate, mix well, and press to form Gabapentin Mecobalamin Dispersion piece.

Embodiment 2

[0035] prescription:

[0036] Gabapentin 300g

[0037] Methylcobalamin 0.5g

[0038] Lactose 10.5g

[0039] Pregelatinized starch 42g

[0040] Microcrystalline Cellulose 48g

[0041] Low-substituted hydroxypropyl cellulose 18g

[0042] Micronized silica gel 1.5g

[0043] A total of 1000 pieces were made

[0044] Preparation:

[0045] First, the above-mentioned materials were crushed through a 100-mesh sieve, and gabapentin methylcobalamin, lactose, pregelatinized starch, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose were fully mixed, and the pressure was adjusted to press into gabapentin methylcobalt Amine Dispersible Tablets.

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PUM

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Abstract

The invention relates to gabapentin mecobalamin dispersion tablets for treating peripheral nervous diseases such as psychalgia syndrome, etc. and a preparation method thereof, and aims to make up the disadvantages in the prior art and provide a novel preparation, i.e. the gabapentin mecobalamin dispersion tablets to patients and medical workers; wherein, the gabapentin mecobalamin dispersion tablets have swift disintegration, fast absorption and easy administration, can increase the bioavailability and the blood concentration of drugs, and increase the abirritation. Gabapentin mecobalamin is used as a raw material, auxiliary materials with specific types and proportions are added in, and the mixture is pressed into tablets according to the conventional technique of the preparation course.

Description

technical field [0001] The invention relates to a novel pharmaceutical preparation, in particular to gabapentin mecobalamin dispersible tablets for treating neuropathic pain syndrome and other peripheral neurological diseases and a preparation method thereof. Background technique [0002] Neuropathic pain is a debilitating condition characterized by chronic, recurrent severe nerve pain and is often a complication of common diseases or conditions such as diabetes, herpes, cancer, AIDS multiple sclerosis, stroke, trauma or surgery . [0003] Neuropathic pain is a debilitating disease. The disease is estimated to afflict 2.8% to 4.7% of the world's population. Neuropathic pain can have a major impact on the lives of sufferers, taking away many people's ability to work, walk and even dress, as contact with the skin of neuropathic pain sufferers causes unbearable burning pain . Neuropathic pain is often underdiagnosed and undertreated. Neuropathic pain is caused by damage or...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/714A61K47/38A61K47/36A61P25/00A61K31/195
Inventor 王蒙
Owner 北京利乐生制药科技有限公司
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