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Dispersion tablet medicine containing oryzanol and its preparation method

A technology of oryzanol and dispersible tablets, which is applied in the field of drugs for the treatment of nervous system diseases, can solve the problems of low bioavailability, unfavorable rapid absorption, and long disintegration time, and achieve high bioavailability, improved compliance, and disintegration speed fast effect

Inactive Publication Date: 2006-10-04
马志梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the long disintegration time of ordinary tablets, the human body absorbs slowly, which is not conducive to rapid absorption by the human body, and the bioavailability is low; while the injection needs to be injected deep into the muscle, which is inconvenient to use; and oryzanol is widely used clinically and used in large quantities, so it was developed A dosage form with quick effect, high bioavailability and convenient clinical use is very important

Method used

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  • Dispersion tablet medicine containing oryzanol and its preparation method

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Embodiment Construction

[0017] One, the parts by weight proportioning of the embodiment of the present invention:

[0018]

[0019] Note: 1. Add 60% of lactose and microcrystalline cellulose for the first time, and 40% for the second time.

[0020] 2. The same effect can be obtained by experimenting with other substances mentioned above but not listed in the above table (omitted).

[0021] 2. Preparation: Prepare according to the above method.

[0022] Process 1:

[0023] (1) Mixing: First, weigh oryzanol, 60% filler, and 60% disintegrating agent in the formula and mix evenly to make superfine oryzanol powder, and then add an appropriate amount of binder.

[0024] (2) Wet granulation: use wet granulation, pass through a 24-mesh sieve, and then dry.

[0025] (3) Grain sizing, etc.: pass through a 36-mesh sieve, weigh the remaining fillers, disintegrants, flow aids, and lubricants and mix them with the above-mentioned granules, then compress them into tablets to obtain finished oryzanol dispersib...

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Abstract

The invention relates to a dispersible tablet containing oryzanol for treating neurological system diseases and its preparing process, wherein the tablet comprises (by weight parts): oryzanol 5-200, filling agent 20-200, crumbling agent 15-40, bonding agent 1-70, flowing adjuvant or lubricating agent 0-5.

Description

technical field [0001] The invention relates to the technical field of drugs for treating nervous system diseases, in particular to a dispersible tablet drug containing oryzanol and a preparation method thereof. Background technique [0002] Oryzanol is a mixture of ferulic acid esters mainly composed of cycloartenols, also known as ferulic acid esters, the English name is r-oryzanol, and it mainly exists in rice bran oil. Oryzanol is white or off-white crystalline powder, odorless; soluble in chloroform and acetone, slightly soluble in ethanol or n-heptane, insoluble in water. Because oryzanol acts on the human body to treat many diseases, its clinical application is extremely extensive. The clinically widely used dosage form of oryzanol is tablets, each containing 10 mg of oryzanol. The usage and dosage are 10-20 mg orally each time, 3 times a day. Another clinically available oryzanol dosage form is the oryzanol injection developed and marketed in recent years. It is a...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61K9/20A61P25/00
Inventor 马志梅赵旺潘娜
Owner 马志梅
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