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'Yi Kang Bu Yuan' formulation for benefiting qi, moving blood, invigorating spleen and tonifying kidney, its preparation method and quality control method

A technology that invigorates the spleen, invigorates the kidney, replenishes qi and activates blood circulation, and is applied to medical preparations containing active ingredients, pharmaceutical formulas, drug delivery, etc. It can solve problems such as bad taste, unstable damp heat, etc., and achieves small adverse reactions and good suspension , the effect of increasing stability

Inactive Publication Date: 2007-05-16
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method provided by the invention is reasonable and feasible, and can guide large-scale production, and the dispersible tablet preparation and pellets provided by the invention have good disintegration, high bioavailability, stable quality, and are convenient to take, and are especially suitable for the elderly and those who swallow Take it for patients who have difficulties in taking tablets or capsules; the dripping pill formulation provided by the invention solves the problem of drug instability in case of heat and humidity, and can also cover up the bad taste and smell of the drug, and play the role of increasing stability and improving bioavailability effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0046] Example 2 of the present invention: Astragalus 65.3g, Mahan 18.7g, Angelica 44.3g, Eclipta 51.3g, Atractylodes 44.3g, Safflower 35g, Radix Paeoniae Rubra 32.7g, peach kernel 32.7g, Achyranthes bidentata 35g, Rhizoma Chuanxiong 28g, 16.3g citrus citrus, 23.3g bellflower

[0047] Take Mahan, Angelica, Cangzhu, Peach Kernel, and Chuanxiong to extract the volatile oil by steam distillation, and collect the aqueous solution in a separate device. Add the dregs and other seven medicinal materials such as Astragalus and decoct them twice, for 2 hours for the first time, and 1.5 hours for the second time. liquid, filtered, the filtrate was combined with the above aqueous solution, concentrated to a thick paste with a relative density of 1.35-1.38 at a relative density of 60-65°C, dried, added absolute ethanol as a wetting agent to make a soft material, and passed through a 24-mesh sieve to obtain wet granules , then put it into a sugar coating machine with a rotation speed of 40...

Embodiment 3

[0048] Example 3 of the present invention: Astragalus 65.3g, Mahan 18.7g, Angelica 44.3g, Eclipta 51.3g, Atractylodes 44.3g, Safflower 35g, Radix Paeoniae Rubra 32.7g, peach kernel 32.7g, Achyranthes bidentata 35g, Rhizoma Chuanxiong 28g, 16.3g citrus citrus, 23.3g bellflower

[0049] Take Mahan, Angelica, Cangzhu, Peach Kernel, and Chuanxiong to extract the volatile oil by steam distillation, and collect the aqueous solution in a separate device. Add the dregs and other seven medicinal materials such as Astragalus and decoct them twice, for 2 hours for the first time, and 1.5 hours for the second time. liquid, filtered, the filtrate was combined with the above aqueous solution, concentrated to a thick paste with a relative density of 1.35 to 1.38 at a relative density of 60 to 65°C, dried, and pulverized to obtain a dry paste powder, added 5% lactose, 9% cross-linked polyvinylpyrrolidone, mixed Mix well, add ethanol, make soft material, granulate, dry, granulate with 40 mesh ...

Embodiment 4

[0050] Example 4 of the present invention: Astragalus 65.3g, Mahan 18.7g, Angelica 44.3g, Eclipta 51.3g, Atractylodes 44.3g, Safflower 35g, Radix Paeoniae Rubra 32.7g, peach kernel 32.7g, Achyranthes bidentata 35g, Rhizoma Chuanxiong 28g, 16.3g citrus citrus, 23.3g bellflower

[0051] Take Mahan, Angelica, Cangzhu, Peach Kernel, and Chuanxiong to extract the volatile oil by steam distillation, and collect the aqueous solution in a separate device. Add the dregs and other seven medicinal materials such as Astragalus and decoct them twice, for 2 hours for the first time, and 1.5 hours for the second time. liquid, filtered, the filtrate was combined with the above aqueous solution, concentrated to a thick paste with a relative density of 1.35 to 1.38 when the relative density was 60 to 65°C, dried, sprayed into the above volatile oil, and added PEG4000 according to extract powder: matrix = 1:1, 60°C For heat preservation, the dripper model adopts No. 1 dripper, drop the medicinal...

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PUM

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Abstract

The invention relates to a preparation having the functions of promoting blood circulation, enlivening spleen and tonifying kidney, the process for preparation and quality control method, wherein the preparation is produced mainly from astragalus root, Chinese ephedra, Chinese angelica root, herba ecliptae, atractylodes rhizome, safflower, radix paeoniae rubrathe, peach kernels, achyranthes and cyathula root, Ligusticum wallichii, bitter orange and root of balloonflower. The preparation can be made into injections and various oral administration preparations including dripping pills, mini-pills and dispersible tablets. The invention also provides the method for determining and identifying contents of the preparation.

Description

technical field [0001] The invention relates to a Yikang tonifying essence preparation with the functions of nourishing qi, activating blood, invigorating the spleen and tonifying the kidney, a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicine. technical background [0002] Yikang Buyuan Granules are mainly composed of Astragalus, Mahan, Angelica, Eclipta, Atractylodes, Safflower, Chishao, peach kernel, Achyranthes bidentata, Chuanxiong, Citrus aurantii, and Campanulaceae. This prescription nourishes qi and activates blood, invigorates the spleen and kidney. For qi deficiency and blood stasis, spleen and kidney deficiency caused by fatigue, shortness of breath, insomnia, soreness of the waist and knees, lack of food and forgetfulness. However, it has been found in long-term clinical practice that the extract obtained from water extraction of medicines such as Astragalus membranaceus of this product co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61K9/00A61P1/14
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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