43 results about "Cefetamet Pivoxil Hydrochloride" patented technology

The invention discloses a cefetamet pivoxil hydrochloride tablet and a preparation method thereof. On the premise of specific active ingredients of the cefetamet pivoxil hydrochloride, the invention takes into account the varieties and dosages of disintegrating agents and joint usage thereof, suitable components and ratios of bonding agents and other filling agents, and the micronization treatment of the raw and auxiliary materials and selection of corresponding optimized process conditions. Experiment results indicate that compared with the prior art, the product of the invention has quick disintegration and dissolution and stable quality.

The invention discloses a cefetamet pivoxil hydrochloride compound and a preparation method thereof. In the method, the crude product of cefetamet pivoxil hydrochloride prepared by the prior art is processed by the following steps to obtain a relatively pure cefetamet pivoxil hydrochloride compound: the crude product of cefetamet pivoxil hydrochloride is dissolved in methanol or alcohol, and then sodium hydroxide solution or potassium hydroxide solution is added; the mixed solution is stirred for reaction and hydrolyzed to obtain cefetamet pivoxil sodium salt or cefetamet pivoxil sylvite which is then absorbed with added active carbon and filtered; and then iodo-ester is added and reaction is conducted in the presence of an organic solvent to obtain cefetamet pivoxil; the cefetamet pivoxil dissolves in isopropyl alcohol, hydrochloric acid is added in a dropwise manner and cyclohexane is added, and the mixed solution is stirred to separate out crystal; and the crystal is filtered, washed and dried to obtain cefetamet pivoxil hydrochloride.

A dispersing tablet of cefetamet hydrochloride is prepared from the active component, filler, disintegrant, flavouring, lubricant and adhesive through proportionally mixing, granulating, adding auxiliaries, stirring and tabletting.

The invention discloses a medicinal cefetamet pivoxil hydrochloride composition for treating sensitive bacteria infectious diseases, and belongs to the field of medical technology. The medicinal cefetamet pivoxil hydrochloride composition is prepared from cefetamet pivoxil hydrochloride, compressible starch, microcrystalline cellulose 102, carboxymethyl starch sodium, hydroxypropylcellulose, glyceryl behenate and magnesium stearate. Experiments discover that compared with the prior art, the tablet prepared by novel crystal type compound of the cefetamet pivoxil hydrochloride is relatively low in high-molecular polymer content and good in stability; the increasing of the content of the high-molecular polymer is quite few with the increasing of storage time; meanwhile, the composition has more remarkable antimicrobial activity on pneumococcus and hemophilus influenzae as well as has relatively strong antimicrobial activity on enterococcus and staphylococcus.

The invention is applicable to the technical field of pharmaceuticals, and provides a cefetamet pivoxil hydrochloride capsule and a preparation method thereof. The cefetamet pivoxil hydrochloride capsule comprises cefetamet pivoxil hydrochloride, a diluting agent, an antitack agent, a surface active agent, a lubricant and a disintegrating agent. In the cefetamet pivoxil hydrochloride capsule disclosed by the invention, the antitack agent, namely, colloidal silicon dioxide (N2O), is adopted to prevent the cefetamet pivoxil hydrochloride medicament from being agglomerated and caked so as to promote dissolution and release of the medicament; and by the use of the diluting agent, the further dispersion of the cefetamet pivoxil hydrochloride is realized, and the agglomeration phenomenon is reduced. The preparation method of the cefetamet pivoxil hydrochloride capsule is simple to operate, saves the processing step of material granulating, avoids the essential components from decomposing due to high temperature and high moisture, has low cost, and is beneficial to reducing the input of equipment funds; the preparation method is suitable for industrial production; and the product prepared by the method disclosed by the invention has the advantages of low water content, few impurities, desirable dissolution performance, and stable quality.

The invention relates to a cefetamet pivoxil hydrochloride capsule which contains the raw materials by the weight percent: 59% of effective and active ingredient, 10-15% of disintegrant, 1-3% of solubilizer, 20-28% of bulking agent and 2-3% of lubricating agent; wherein the effective and active ingredient is cefetamet pivoxil hydrochloride; the disintegrant comprises sodium carboxymethyl starch and cross-linked sodium carboxyl cellulose; the solubilizer is lauryl sodium sulfate; the bulking agent is one or two of lactose and mannitol; and the lubricating agent includes superfine silica powder and magnesium stearate. The invention also discloses a preparation method of the cefetamet pivoxil hydrochloride capsule, which adopts dry pressing pelletization technique; therefore, the invention has the advantages of simple equipment and less investment; the prepared capsule is stable in quality, excellent in solubility property, rapid in absorption, convenient in taking and good in mouthfeel.

A medicine in the form of tablet, capsule, particle, oral liquid, or suspension for treating pulmonary infectious diseases is prepared from ambroxol hydrochloride and one of cefixime, cefetamet sodium and cefetamet hydrochloride.

The invention provides granules of cefetamet pivoxil hydrochloride and a preparation method thereof, which belong to the technical field of medicine. The granularity of the granules is 200-1600mu m, and the granules are prepared from fine cefetamet pivoxil hydrochloride coating granules and pharmaceutically acceptable auxiliary materials. The fine cefetamet pivoxil hydrochloride coating granules are obtained by coating after cefetamet pivoxil hydrochloride and auxiliary materials are prepared into fine granules by a spray method of a fluidized bed, wherein the fine cefetamet pivoxil hydrochloride coating granules account for 30-75% of the total weight of the entire granules. A coating material used for coating contains a film-forming material, a plasticizer and an antiblocking agent; the invention has the advantages of completely covering up the special bitter taste of the cefetamet pivoxil hydrochloride and enhancing the application conformability of the aged, children and patients with difficulties in deglutition.

The invention provides a cefetamet pivoxil hydrochloride hydrate, wherein an X-ray powder diffraction spectrogram obtained by measurement by using Cu-Kalpha rays is represented by the figure 1. Cefetamet pivoxil hydrochloride hydrate crystals disclosed by the invention are good in stability, difficult to absorb moisture and good in mobility and can be uniformly mixed with other accessories; and a prepared cefetamet pivoxil hydrochloride dispersible table is rapid in absorption speed and high in bioavailability.

The invention belongs to technical field of medicine, and relates to a cefetamet pivoxil hydrochloride compound for treating sensitive bacteria infectious diseases. An X-ray powder diffraction pattern of the cefetamet pivoxil hydrochloride compound measured by virtue of a Cu-Kalpha ray is shown in a figure 1. The cefetamet pivoxil hydrochloride compound is a novel crystal form compound, and is different from cefetamet pivoxil hydrochloride reported in the prior art. An experiment proves that compared with the prior art, the novel crystal form compound of the cefetamet pivoxil hydrochloride has relatively low high-molecular polymer content and good stability; the increase of the content of the high-molecular polymer is reduced along with prolonging of the storage time; and meanwhile, the compound has relatively significant antibacterial activity on pneumococcus and hemophilus influenza, and has relatively high antibacterial activity on enterococcus and staphylococcus.

The present invention discloses a cefetamet pivovil double-function esterification precursor medicine compound. Said invention also provides its chemical name, structure general formula and various oral dosage forms. Said compound has higher water solubility and strong and high-effective antibacterial activity.

The invention provides a cefetamet pivoxil hydrochloride submicron emulsion solid preparation, which comprises the following components in part by weight: 1 part of cefetamet pivoxil hydrochloride submicron emulsion grains, 0.4 to 3 parts of diluent, 0 to 0.5 part of disintegrating agent, 0 to 0.2 part of adhesive, 0 to 6 parts of flavoring agent, 0 to 0.4 part of aromatizer and 0 to 0.2 part of lubricant. The invention also discloses application of the preparation in preparation of a medicament for treating cholangitis, particularly acute pyogenic cholangitis.

The invention relates to a cefetamet pivoxil hydrochloride preparation method, which comprises: generating an intermediate I by using 7-ADCA and ethyl methylaminothiazolyloximate as starting raw materials under the catalysis of AlMe3; and carrying out an esterification reaction on the intermediate I and iodomethyl pivalate under the actions of a phase transfer catalyst and an acid adsorbent, carrying out salt formation on the esterified product, and crystallizing to obtain the target product cefetamet pivoxil hydrochloride. According to the present invention, the method has characteristics ofmild reaction conditions, high product purity, high yield and stable process, and is suitable for industrial production.

The invention belongs to the field of chemistry, which in particular relates to a method for preparing cefetamet which is an intermediate of cefetamet pivoxil hydrochloride. By optimizing the process, especially improving the synthesis ratio of raw materials and a crystal growing process, the invention enhances the yield and the purity of a product. The method for preparing the cefetamet, which is provided by the invention, has the advantages of mild reaction conditions and little discharge of three wastes, also has stable process and is suitable for industrial large-scale production.

The invention discloses a cefetamet pivoxil hydrochloride tablet and a preparation method thereof. On the premise of specific active ingredients of the cefetamet pivoxil hydrochloride, the invention takes into account the varieties and dosages of disintegrating agents and joint usage thereof, suitable components and ratios of bonding agents and other filling agents, and the micronization treatment of the raw and auxiliary materials and selection of corresponding optimized process conditions. Experiment results indicate that compared with the prior art, the product of the invention has quick disintegration and dissolution and stable quality.

The invention relates to the field of a medicine, in particular to a cefetamet pivoxil hydrochloride dispersible tablet and a preparation method of the cefetamet pivoxil hydrochloride dispersible tablet. The cefetamet pivoxil hydrochloride dispersible tablet is prepared by the following components in parts by weight: 40 to 60% of cefetamet pivoxil hydrochloride, 10 to 20% of microcrystalline cellulose, 5 to 15% of polyvinylpolypyrrolidone, 5 to 12% of calcium hydrophosphate and 5 to 15% of carboxymethyl starch sodium. Compared with the ordinary tablet, the cefetamet pivoxil hydrochloride dispersible tablet provided by the invention has the advantages of being good in disperse state, short in disintegration time, high in bioavailability, little in untoward effect, rapid to dissolve the medicines, fast to absorb and convenient to take and the like.

The invention relates to the medical field, in particular to a cefetamet pivoxil hydrochloride dispersible tablet and a preparation method thereof. The cefetamet pivoxil hydrochloride dispersible tablet is prepared by the following components, by weight: 40-60% of cefetamet pivoxil hydrochloride, 10-20% of microcrystalline cellulose, 5-15% of polyvinylpolypyrrolidone, 5-12% of calcium hydrophosphate, 5-15% of sodium starch glycolate, 0.5-5% of silicon dioxide, 0.5-5% of magnesium stearate, 0.01-0.2% of steviosin and a proper amount of water. Compared with the ordinary tablets and capsules, the cefetamet pivoxil hydrochloride dispersible tablet has the advantages of being good in dispersing state, short in disintegration time, fast in medicine dissolution and absorption, high in bioavailability, few in bar reaction, convenient to take and the like.

The invention discloses a medicinal cefetamet pivoxil hydrochloride dry suspension for treating sensitive bacterial infection diseases and belongs to the technical field of medicine. The dry suspension is prepared from cefetamet pivoxil hydrochloride, dextrin, sucrose, HPMC, xanthan gum and absolute ethyl alcohol. The cefetamet pivoxil hydrochloride is a novel crystal-form compound. As shown in Figure 1 of X-ray powder diffraction diagram obtained by means of Cu-K alpha ray measurement, the cefetamet pivoxil hydrochloride is different from cefetamet pivoxil hydrochloride reported in the prior art. Tests find that the dry suspension prepared from the novel crystal-form compound of the cefetamet pivoxil hydrochloride is low in high-molecular polymer content and good in stability, and the content of high-molecular polymers gradually decreases along with prolonging of storage time; meanwhile, the composition has more remarkable antibacterial activity with respect to pneumococcocci and hemophilus influenza and also has strong antibacterial activity with respect to enterococcocci and staphylococcocci.

The invention discloses an anti-infective drug cefetamet pivoxil hydrochloride composite capsule and belongs to the technical field of drugs. A composite is prepared from cefetamet pivoxil hydrochloride, microcrystalline cellulose, magnesium aluminum silicate, povidone K30, anhydrous ethanol and magnesium stearate. The cefetamet pivoxil hydrochloride is a new crystal type compound. An X-ray powder diffraction diagram obtained through Cu-K alpha ray measurement is shown in figure one. The cefetamet pivoxil hydrochloride is different from cefetamet pivoxil hydrochloride reported in the prior art. As is found in experiments, the capsule prepared from the cefetamet pivoxil hydrochloride new crystal type compound is low in high-molecular polymer content and good in stability, and the content of high-molecular polymers is little increased along with prolonging of storage time. Meanwhile, the composite has more remarkable antibacterial activity on pneumococcus and hemophilus influenzae and also has high antibacterial activity on enterococcus and staphylococcus.

The invention discloses a cefetamet pivoxil hydrochloride crystal form II. The X-ray powder diffractogram of the crystal form II measured by Cu-Kalpha rays has characteristic absorption peaks when 2theta is 4.8+ / -0.2 degrees, 7.3+ / -0.2 degrees, 11.7+ / -0.2 degrees, 12.4+ / -0.2 degrees, 14.6+ / -0.2 degrees, 19.0+ / -0.2 degrees, 22.2+ / -0.2 degrees and 24.6+ / -0.2 degrees. The preparation method comprises the following steps: (1) dissolving cefetamet pivoxil hydrochloride in an organic solvent in a weight ratio of 1:(1-5); and (2) adding water or a poor solvent, crystallizing at room temperature for 3-8 hours, filtering, and carrying out forced air drying at room temperature for 5-6 hours to obtain the cefetamet pivoxil hydrochloride crystal form II. The preparation method is simple, has the advantages of mild conditions and low cost, and can be performed at room temperature; and the prepared product has high yield and high purity (up to 99.5% or above), and has favorable pharmaceutical development value.

The invention provides granules of cefetamet pivoxil hydrochloride and a preparation method thereof, which belong to the technical field of medicine. The granularity of the granules is 200-1600mu m, and the granules are prepared from fine cefetamet pivoxil hydrochloride coating granules and pharmaceutically acceptable auxiliary materials. The fine cefetamet pivoxil hydrochloride coating granules are obtained by coating after cefetamet pivoxil hydrochloride and auxiliary materials are prepared into fine granules by a spray method of a fluidized bed, wherein the fine cefetamet pivoxil hydrochloride coating granules account for 30-75% of the total weight of the entire granules. A coating material used for coating contains a film-forming material, a plasticizer and an antiblocking agent; the invention has the advantages of completely covering up the special bitter taste of the cefetamet pivoxil hydrochloride and enhancing the application conformability of the aged, children and patients with difficulties in deglutition.

The invention discloses a cefetamet pivoxil hydrochloride slow release tablet, which solves the problems that in the prior art, during the oral preparation administration, the blood medicine concentration of the medicine in lesion positions in different time periods is not uniform; a medicine administration wave peak and trough condition exists, so that the medicine effectiveness is not constant and not durable. The cefetamet pivoxil hydrochloride slow release tablet is prepared from 1 to 4 parts of cefetamet pivoxil hydrochloride, 1 to 3 parts of microcrystalline cellulose, 16 to 20 parts ofmaltitol, 2 to 4 parts of betadex and 1 to 3 parts of hydrogenated vegetable oil in parts by weight. The cefetamet pivoxil hydrochloride slow release tablet has the advantages that the medicine effectcan be better released, so that the medicine effect can be uniformly released in the process of being kept in the mouth; the curative effect is more stable and durable.

The invention discloses a pharmaceutical composition containing cefetamet pivoxil hydrochloride. According to the pharmaceutical composition, sodium cyclamate is added into the composition and is usedas a gel inhibitor, and a phenomenon that a solid preparation forms gel in a water-soluble solution is effectively inhibited; the dissolution performance of the solid preparation is effectively improved and the bioavailability is improved. The sodium cyclamate has a sweet taste so that the problem that a granular preparation has a bitter taste is solved. A dry-process granulation technology is adopted so that introduction of bad factors including moisture, high temperature and the like is avoided; a preparation prescription is matched so that the problem of hydrolysis or oxidative degradationof an ester bond, an amide bond, a lactam bond and a primary amine bond in crude drug molecules is solved. A test proves that the effect is good.

The invention provides a cefetamet pivoxil hydrochloride liposome solid preparation and a preparation method thereof. The cefetamet pivoxil hydrochloride liposome solid preparation comprises 125 parts of cefetamet pivoxil hydrochloride, 20 to 250 parts of aluminum dicetyl phosphate, 50 to 200 parts of cholesterol, 10 to 150 parts of tween 80 and 100 to 250 parts of other medicinal auxiliary materials. The cefetamet pivoxil hydrochloride liposome solid preparation can be processed into tablets and particles. The cefetamet pivoxil hydrochloride liposome solid preparation has a high entrapment rate, even particle sizes and long retention time of drugs in blood circulation. The preparation method of the cefetamet pivoxil hydrochloride liposome solid preparation improves preparation quality, reduces toxic and side effects, needs simple equipment, is easy for operation and is suitable for industrialized large-scale production.

The invention relates to an anti-infection drug cefetamet pivoxil hydrochloride composition, and belongs to the technical field of medicine. The composition is prepared from cefetamet pivoxil hydrochloride and sodium chloride; the cefetamet pivoxil hydrochloride is a crystal, an X-ray powder diffraction pattern obtained by being measured through Cu-K alpha-ray is shown in Figure 1, the main crystal size of the cefetamet pivoxil hydrochloride ranges from 200 microns to 300 microns, and the distribution width ranges from 185 microns to 315 microns. The novel crystal type of the cefetamet pivoxil hydrochloride is different from a crystal structure in the prior art, it is verified through experiments that compared with the prior art, a powder injection prepared from the novel crystal-type composition is good in fluidity, lower in high-molecular polymer content and good in stability, and the content of high-molecular polymers is increased a little along with prolonging of storing time; meanwhile, the composition has more significant antibacterial activity in pneumococcus and bacillus influenzae and has stronger antibacterial activity in enterococcus and staphylococcus.

The invention relates to a medicinal composition, which contains cefetamet pivoxil hydrochloride and mannitol and is applied orally. .The medicinal composition comprises 100 weight parts of cefetamet pivoxil hydrochloride and 10 to 200 weight parts of mannitol. The medicinal composition of the invention solves the problems that the dissolution of the cefetamet pivoxil hydrochloride in the capsules of the cefetamet pivoxil hydrochloride is low, and the colors of contents are deepened due to wet granulation.