Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cefetamet pivoxil hydrochloride capsule and preparation method thereof

A technology of ceftamet pivoxil hydrochloride and capsules, which is applied in the field of ceftamet pivoxil hydrochloride capsules and its preparation, can solve problems such as relatively large impact on product quality, easy degradation of active ingredients, and conflicting psychology, and achieve good dissolution effect and dissolution Excellent performance, the effect of improving viscosity

Active Publication Date: 2009-12-30
ZHEJIANG YATAI PHARMA
View PDF2 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, due to the extremely bitter taste of the ceftazidime pivoxil hydrochloride raw material, the direct production of tablets affects the taste, and the drug users will have a resistance to taking the medicine, so they need to be coated or added with a flavoring agent before taking it. Capsules are a kind of medicine that can cover up the bitter taste Commonly used dosage forms
In addition, ceftametoxo pivoxil hydrochloride raw material drug is relatively viscous. At present, wet granulation is mostly used to improve the fluidity of the drug. However, due to its unstable properties under high temperature and high humidity conditions, the use of wet granulation has a great impact on product quality. Contains active ingredients that are easily degraded

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefetamet pivoxil hydrochloride capsule and preparation method thereof
  • Cefetamet pivoxil hydrochloride capsule and preparation method thereof
  • Cefetamet pivoxil hydrochloride capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]

[0040] Dry sodium carboxymethyl starch at 120°C for 4 hours, seal it with a double-layer plastic bag and put it in a stainless steel turnover bucket for later use; dry the lactose at 80°C for 4 hours, seal it with a double-layer plastic bag and put it in a stainless steel turnover barrel for later use; After the alcohol is dried at 80°C for 4 hours and passed through an 80-mesh sieve, it is sealed with a double-layer plastic bag and put into a stainless steel turnover bucket for later use.

[0041] Put the above-mentioned dried sodium carboxymethyl starch, lactose and mannitol, croscarmellose sodium, sodium lauryl sulfate and micropowder silica gel into the mixer and pre-mix for 10 minutes. After mixing evenly, add 1 / 2 The prescription amount of ceftazidime pivoxil hydrochloride was premixed for 10 minutes, and then 1 / 2 of the prescription amount of ceftazime pivoxil hydrochloride was added and mixed evenly to obtain a mixed material.

[0042]The above mixed materi...

Embodiment 2

[0045]

[0046] The preparation method is the same as in Example 1.

Embodiment 3

[0048]

[0049] The preparation method is the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a cefetamet pivoxil hydrochloride capsule which contains the raw materials by the weight percent: 59% of effective and active ingredient, 10-15% of disintegrant, 1-3% of solubilizer, 20-28% of bulking agent and 2-3% of lubricating agent; wherein the effective and active ingredient is cefetamet pivoxil hydrochloride; the disintegrant comprises sodium carboxymethyl starch and cross-linked sodium carboxyl cellulose; the solubilizer is lauryl sodium sulfate; the bulking agent is one or two of lactose and mannitol; and the lubricating agent includes superfine silica powder and magnesium stearate. The invention also discloses a preparation method of the cefetamet pivoxil hydrochloride capsule, which adopts dry pressing pelletization technique; therefore, the invention has the advantages of simple equipment and less investment; the prepared capsule is stable in quality, excellent in solubility property, rapid in absorption, convenient in taking and good in mouthfeel.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a ceftazidime hydrochloride capsule and a preparation method thereof. Background technique [0002] In today's society, people's living standards are constantly improving, and people pay more attention to medical and health care. β-lactam antibiotics, as a class of antibiotics with the largest clinical dosage, the most widely used, the most varieties, and the best curative effects, are more and more popular among the people. Consumption is increasing year by year. Among them, cephalosporin products accounted for about 70%. [0003] Ceftazidime pivoxil hydrochloride, as a key variety of cephalosporin products, was listed as one of the varieties recommended for research and development during the "Tenth Five-Year Plan" period in my country, and has great market development potential. The tablet of ceftazidime pivoxil hydrochloride was researched and developed by F.Hoffm...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/546A61K47/38A61K47/36A61P31/04
Inventor 吕旭幸王丽云陈洁
Owner ZHEJIANG YATAI PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com