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Pharmaceutical composition containing cefetamet pivoxil hydrochloride

A technology of ceftamet pivoxil hydrochloride and composition, which is applied in the field of pharmaceutical composition containing ceftamet pivoxil hydrochloride and its preparation, and can solve problems such as gelation, poor drug dissolution, and high requirements for fillers

Inactive Publication Date: 2018-06-15
董贵雨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wetting agent water or alcohol needs to be added in the process of wet granulation, which is easy to cause gelation and serious caking phenomenon
The effect of powder direct compression is poor, so it is generally necessary to add a large amount of fillers, and the requirements for fillers are high, which greatly increases the preparation cost and the drug dissolution is not good
Dry granulation can avoid the gelation problem of wet granulation, and the obtained granules can be used to prepare tablets, capsules or granules. falling problem

Method used

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  • Pharmaceutical composition containing cefetamet pivoxil hydrochloride
  • Pharmaceutical composition containing cefetamet pivoxil hydrochloride
  • Pharmaceutical composition containing cefetamet pivoxil hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] Embodiment 1 Ceftazidime pivoxil hydrochloride film-coated tablet preparation (unit: g)

[0125] prescription:

[0126]

[0127] The preparation process is as follows:

[0128] 1) Get ceftazime pivoxil hydrochloride crude drug and pulverize, cross 200 mesh sieves, set aside;

[0129] 2) Take the filler mannitol, 50% of the prescription amount of the disintegrating agent low-substituted hydroxypropyl cellulose, sieve, and set aside;

[0130] 3) Take the prescribed amount of ceftazidime hydrochloride, filler mannitol and 50% of the prescribed amount of disintegrating agent low-substituted hyprolose, mix well, dry granulate, and granulate to obtain drug-loaded ceftazidime hydrochloride granules ;

[0131] 4) Take the drug-loaded ceftazidime pivoxil hydrochloride granules, the remaining 50% of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose, the gel inhibitor sodium cyclamate, and the lubricant magnesium stearate, and mix them evenl...

Embodiment 2

[0134] Embodiment 2 Ceftamet pivoxil hydrochloride hard capsule preparation (unit: g)

[0135] prescription:

[0136]

[0137] The preparation process is as follows:

[0138] 1) Get ceftazime pivoxil hydrochloride crude drug and pulverize, cross 200 mesh sieves, set aside;

[0139] 2) Take the filler mannitol, 50% of the prescription amount of the disintegrating agent low-substituted hydroxypropyl cellulose, sieve, and set aside;

[0140] 3) Take the prescribed amount of ceftazidime hydrochloride, filler mannitol and 50% of the prescribed amount of disintegrating agent low-substituted hyprolose, mix well, dry granulate, and granulate to obtain drug-loaded ceftazidime hydrochloride granules ;

[0141] 4) Take the drug-loaded ceftazidime pivoxil hydrochloride granules, the remaining 50% of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose, the gel inhibitor sodium cyclamate, and the lubricant magnesium stearate, and mix them evenly to obta...

Embodiment 3

[0143] Embodiment 3 preparation of ceftazidime pivoxil hydrochloride granules (unit: g)

[0144] prescription:

[0145]

[0146] The preparation process is as follows:

[0147] 1) Get ceftazime pivoxil hydrochloride crude drug and pulverize, cross 200 mesh sieves, set aside;

[0148] 2) Take the filler mannitol, 50% of the prescription amount of the disintegrating agent low-substituted hydroxypropyl cellulose, sieve, and set aside;

[0149] 3) Take the prescribed amount of ceftazidime hydrochloride, filler mannitol and 50% of the prescribed amount of disintegrating agent low-substituted hyprolose, mix well, dry granulate, and granulate to obtain drug-loaded ceftazidime hydrochloride granules ;

[0150] 4) Take the drug-loaded ceftazidime pivoxil hydrochloride granules, the remaining 50% of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose, the gel inhibitor sodium cyclamate, and the lubricant magnesium stearate, and mix them evenly to ob...

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Abstract

The invention discloses a pharmaceutical composition containing cefetamet pivoxil hydrochloride. According to the pharmaceutical composition, sodium cyclamate is added into the composition and is usedas a gel inhibitor, and a phenomenon that a solid preparation forms gel in a water-soluble solution is effectively inhibited; the dissolution performance of the solid preparation is effectively improved and the bioavailability is improved. The sodium cyclamate has a sweet taste so that the problem that a granular preparation has a bitter taste is solved. A dry-process granulation technology is adopted so that introduction of bad factors including moisture, high temperature and the like is avoided; a preparation prescription is matched so that the problem of hydrolysis or oxidative degradationof an ester bond, an amide bond, a lactam bond and a primary amine bond in crude drug molecules is solved. A test proves that the effect is good.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing ceftazidime pivoxil hydrochloride and a preparation method thereof. Background technique [0002] Cefetamet Pivoxil is an oral third-generation cephalosporin. After oral administration, it is deesterified by intestinal wall esterase to release cephalosporin with antibacterial activity. Spectrum antibacterial effect. Ceftazidime hydrochloride may have an effect on Treponema pallidum, but has little effect on anaerobic bacteria. The effective rates of ceftazidime hydrochloride in the treatment of respiratory system infection, urinary system infection and bacteremia were 83.3%, 91.2% and 66.6%, respectively. According to the clinical curative effect analysis of different daily doses on various diseases, the effective rates of 500mg or 1000mg per day are 92.65% and 91.4% for acute respiratory infections, 71.4% and 93.2% for pulm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K9/16A61K47/26A61K47/20A61K47/38A61K47/12A61K9/36A61K9/48A61P31/04
CPCA61K31/546A61K9/1617A61K9/1623A61K9/1652A61K9/2054
Inventor 不公告发明人
Owner 董贵雨
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