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Anti-infection drug cefetamet pivoxil hydrochloride composition

A technology of ceftazime pivoxil hydrochloride and a composition, which is applied in the field of anti-infective drug ceftazime pivoxil hydrochloride composition, can solve the problems of patient harm, immediate allergic reaction and the like, and achieves low polymer content and significant antibacterial activity. , the effect of strong antibacterial activity

Inactive Publication Date: 2015-12-30
QINGDAO HUAZHICAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, because its basic structure is the same as that of many semi-synthetic β-lactam lactam antibiotics already on the market, ceftazidime hydrochloride will also form high molecular polymers, which will also cause immediate hypersensitivity reactions in clinical use, which is harmful to patients. great

Method used

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  • Anti-infection drug cefetamet pivoxil hydrochloride composition
  • Anti-infection drug cefetamet pivoxil hydrochloride composition
  • Anti-infection drug cefetamet pivoxil hydrochloride composition

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1: Preparation of ceftazidime pivoxil hydrochloride crystal

[0029] (1) Grind the crude ceftazidime pivoxil hydrochloride, pass through a 300 mesh sieve, add it into the N-ethylacetamide solution, and heat up to 30°C while stirring; The weight ratio of the solution is 1:15; the stirring speed is 260 rpm; adding activated carbon, stirring for 120 minutes and then sterile filtering;

[0030] (2) Add diethyl ether while stirring, and lower the temperature to -2°C at the same time; the stirring speed is 180 rev / min; 70ml / min; cooling rate is 3°C / hour;

[0031] (3) After adding the mixed solvent, the obtained crystals were left to stand for crystallization; filtered, washed, and vacuum-dried for 6 hours to obtain the ceftazidime hydrochloride compound.

[0032] The X-ray powder diffraction pattern obtained by the ceftazidime hydrochloride crystals prepared using Cu-Kα ray measurement is as follows figure 1 As shown, through scanning electron microscope observat...

Embodiment 2

[0033] Example 2: Preparation of ceftazidime pivoxil hydrochloride composition

[0034] The composition is: 1 part by weight of ceftazidime hydrochloride crystal prepared in Example 1 of the present invention, and 0.6 part by weight of sodium chloride.

[0035] The preparation method is:

[0036] (1) Weigh the ceftazidime pivoxil hydrochloride crystals and sodium chloride in proportion, and mix them thoroughly;

[0037] (2) Dispense into sterilized vials and stopper them.

Embodiment 3

[0038] Example 3: Preparation of ceftazidime pivoxil hydrochloride composition

[0039] The composition is: 1 part by weight of ceftazidime hydrochloride crystal prepared in Example 1 of the present invention, and 0.7 part by weight of sodium chloride.

[0040] The preparation method is:

[0041] (1) Weigh the ceftazidime pivoxil hydrochloride crystals and sodium chloride in proportion, and mix them thoroughly;

[0042] (2) Dispense into sterilized vials and stopper them.

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Abstract

The invention relates to an anti-infection drug cefetamet pivoxil hydrochloride composition, and belongs to the technical field of medicine. The composition is prepared from cefetamet pivoxil hydrochloride and sodium chloride; the cefetamet pivoxil hydrochloride is a crystal, an X-ray powder diffraction pattern obtained by being measured through Cu-K alpha-ray is shown in Figure 1, the main crystal size of the cefetamet pivoxil hydrochloride ranges from 200 microns to 300 microns, and the distribution width ranges from 185 microns to 315 microns. The novel crystal type of the cefetamet pivoxil hydrochloride is different from a crystal structure in the prior art, it is verified through experiments that compared with the prior art, a powder injection prepared from the novel crystal-type composition is good in fluidity, lower in high-molecular polymer content and good in stability, and the content of high-molecular polymers is increased a little along with prolonging of storing time; meanwhile, the composition has more significant antibacterial activity in pneumococcus and bacillus influenzae and has stronger antibacterial activity in enterococcus and staphylococcus.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an anti-infection drug ceftazidime pivoxil hydrochloride composition. Background technique [0002] Ceftazidime pivoxil hydrochloride is a third-generation broad-spectrum cephalosporin antibiotic. After oral administration, it is rapidly hydrolyzed in the body to cefetamet with antibacterial activity to play a bactericidal effect. Ceftazidime hydrochloride has strong antibacterial activity against Gram-positive bacteria such as Streptococcus (except for Streptococcus faecalis), Pneumococcus, Escherichia coli, Klebsiella, influenza bacilli, and Neisseria gonorrhoeae, especially Serratia spp., indole-positive Proteus spp., Enterobacter spp. and Citrobacter spp. with low sensitivity to cephalosporins had obvious antibacterial activity. Stable to β-lactamases produced by bacteria. Ceftazidime hydrochloride is ineffective against Pseudomonas, Mycoplasma, Chlamydia, Enterococcus and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61P31/04A61P31/16C07D501/22C07D501/12
Inventor 刘学键
Owner QINGDAO HUAZHICAO PHARMA CO LTD
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