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Compound medicinal preparation for treating pneumonia infection disease and its preparation method

A technology for pharmaceutical preparations and pulmonary infections, which is applied in the field of anti-infective compound pharmaceutical preparations and its preparation, can solve the problems of large dosage, inaccurate dosage, and influence on the treatment effect, and achieve small dosage, convenient clinical application, and effective The effect of increasing strength

Inactive Publication Date: 2005-08-10
四川川投医药生物技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, clinically, cephalosporin preparations and ambroxol hydrochloride preparations are used as two drugs in combination. Due to the large dosage and inaccurate dosage, the therapeutic effect is affected

Method used

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  • Compound medicinal preparation for treating pneumonia infection disease and its preparation method
  • Compound medicinal preparation for treating pneumonia infection disease and its preparation method
  • Compound medicinal preparation for treating pneumonia infection disease and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation of cefixime ambroxol sheet

[0029] prescription:

[0030] Cefixime 100g

[0031] Ambroxol Hydrochloride 60g

[0032] Starch 25g

[0033] Microcrystalline Cellulose 50g

[0034] Diluted Hydroxypropyl Cellulose 12.5g

[0035] 10% starch slurry 30ml

[0036] Magnesium Stearate 2.5g

[0037] Made into 1000 pieces

[0038] Preparation process: Weigh cefixime, ambroxol hydrochloride, starch, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose according to the above prescription, pass through a 80-mesh sieve after crushing, mix evenly, and add 10% starch slurry to prepare Soft material, pass through a 20-mesh sieve to make wet granules, dry at 50°C for 3 hours, add magnesium stearate, pass through a 18-mesh sieve for granulation, and compress into tablets, each weighing about 0.25g.

Embodiment 2

[0039] Embodiment 2: the preparation of cefixime ambroxol dispersible tablet

[0040] prescription:

[0041] Cefixime 100g

[0042] Ambroxol Hydrochloride 60g

[0043] Lactose 37.5g

[0044] Microcrystalline Cellulose 36g

[0045] Cross-linked polyvinylpyrrolidone 15g

[0046] 10% polyvinylpyrrolidone solution 30ml

[0047] Sodium Lauryl Sulfate 1.5g

[0048] Made into 1000 pieces

[0049] Preparation process: Weigh cefixime, ambroxol hydrochloride, lactose, microcrystalline cellulose, and cross-linked polyvinylpyrrolidone according to the above prescription, pass through an 80-mesh sieve after crushing, mix well, and add 10% polyvinylpyrrolidone solution to prepare Soft material, pass through a 30-mesh sieve to make wet granules, dry at 50°C for 3 hours, add sodium lauryl sulfate, pass through a 20-mesh sieve for granulation, and press into tablets, the weight of the tablet is about 0.25g.

Embodiment 3

[0050] Embodiment 3: the preparation of cefixime ambroxol capsule

[0051] prescription:

[0052] Cefixime 100g

[0053] Ambroxol Hydrochloride 60g

[0054] Starch 25g

[0055] Microcrystalline Cellulose 50g

[0056] Diluted Hydroxypropyl Cellulose 12.5g

[0057] 10% starch slurry 25ml

[0058] Magnesium Stearate 2.5g

[0059] Make 1000 capsules

[0060] Preparation process: Weigh cefixime, ambroxol hydrochloride, starch, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose according to the above prescription, pass through a 80-mesh sieve after crushing, mix evenly, and add 10% starch slurry to prepare Soft material, pass through a 20-mesh sieve to make wet granules, dry at 50°C for 3 hours, add magnesium stearate, pass through a 18-mesh sieve for granulation, fill the capsules, the weight of the capsules is about 0.25g.

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Abstract

A medicine in the form of tablet, capsule, particle, oral liquid, or suspension for treating pulmonary infectious diseases is prepared from ambroxol hydrochloride and one of cefixime, cefetamet sodium and cefetamet hydrochloride.

Description

Technical field: [0001] The invention relates to an anti-infection compound drug preparation and a preparation method thereof, specifically, the invention relates to a compound drug preparation for treating pulmonary infectious diseases and a preparation method thereof. Background technique: [0002] Pulmonary infectious disease is one of common respiratory tract infection diseases. Because cephalosporin antibiotics are stable to β-lactamase, have the characteristics of broad antibacterial spectrum and strong bactericidal effect, they are often used in the treatment of clinical upper respiratory tract infection diseases, especially the third-generation cephalosporin antibiotics, such as Cefixime C 16 h 15 N 5 o 7 S 2 ·3H 2 O), Cefetamet Sodium (Cefetamet Sodium C 14 h 14 N 5 NaO 5 S 2 ), Cefetamet Pivoxil Hydrochloride (Cefetamet Pivoxil HydrochlorideC 14 h 15 N 5 o 7 S 2 HCL) etc. However, the success of antimicrobial therapy not only depends on the sensitiv...

Claims

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Application Information

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IPC IPC(8): A61K31/545A61K45/06A61P11/00A61P31/04
Inventor 朱晓茂莫兆明余安国林国华
Owner 四川川投医药生物技术有限责任公司
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