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Cefetamet pivoxil hydrochloride tablet composition

A technology of ceftazidime hydrochloride and mexil tablets, applied in the field of medicine, can solve problems such as patient harm and immediate allergic reaction, and achieve the effects of low polymer content, significant antibacterial activity, and strong antibacterial activity

Inactive Publication Date: 2016-12-07
YANTAI HUAWEN XINXIN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, because its basic structure is the same as that of many semi-synthetic β-lactam lactam antibiotics already on the market, ceftazidime hydrochloride will also form high molecular polymers, which will also cause immediate allergic reactions in clinical use, which is harmful to patients. great

Method used

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  • Cefetamet pivoxil hydrochloride tablet composition
  • Cefetamet pivoxil hydrochloride tablet composition
  • Cefetamet pivoxil hydrochloride tablet composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the preparation of ceftazidime pivoxil hydrochloride crystal

[0031] Get ceftamet pivoxil hydrochloride crude drug, add the mixed solution that volume is 8 times of ceftamet pivoxil hydrochloride weight diethyl ether and ethanol composition, wherein the volume ratio of diethyl ether and ethanol is 4:2.5, be heated to 30-35 ℃; Hydrochloric acid After the ceftazime pivoxil raw material is dissolved, add activated carbon for decolorization, and filter; the filtrate is heated and kept at a temperature of 35-40°C, and a mixed solvent of dimethylformamide and acetone whose volume is 6 times the weight of ceftamet pivoxil hydrochloride is added dropwise, The volume ratio of dimethylformamide and acetone is 2:1; after dropping, stir and cool down, the stirring and cooling is to cool down to 20-25°C at a speed of 1.5-3.5°C / min under stirring at a speed of 50-75rmp, and then Cool down to 5-10°C at a speed of 0.5-1°C / min under stirring at a speed of 30-45rmp, let st...

Embodiment 2

[0033] Embodiment 2: the preparation of ceftazidime pivoxil hydrochloride tablet, the steps are as follows:

[0034] Prescription: in parts by weight

[0035]

[0036] Preparation:

[0037] 1) Processing of raw and auxiliary materials: Use a vibrating sieving machine to pass compressible starch, microcrystalline cellulose 102, and hydroxypropyl cellulose through a 60-mesh sieve, carboxymethyl starch sodium through a 120-mesh sieve, and ceftazidime pivoxil hydrochloride through a 80-mesh sieve .

[0038] 2) Weighing: Weigh all raw and auxiliary materials according to the prescription;

[0039] 3) Mixing: Add the weighed raw and auxiliary materials into the mixer, set the motor operating frequency to 200r / min, and start the mixer to mix for 25 minutes;

[0040] 4) Choose a high-speed tablet press to press the tablet, adjust the pressure so that the tablet can be formed and the hardness is 4-9kgf, and the friability is not more than 1%;

[0041] 5) Packaging.

Embodiment 3

[0042] Embodiment 3: the preparation of ceftazidime pivoxil hydrochloride tablet, the steps are as follows:

[0043] Prescription: in parts by weight

[0044]

[0045] Preparation:

[0046]1) Processing of raw and auxiliary materials: Use a vibrating sieving machine to pass compressible starch, microcrystalline cellulose 102, and hydroxypropyl cellulose through a 60-mesh sieve, carboxymethyl starch sodium through a 120-mesh sieve, and ceftazidime pivoxil hydrochloride through a 80-mesh sieve .

[0047] 2) Weighing: Weigh all raw and auxiliary materials according to the prescription;

[0048] 3) Mixing: Add the weighed raw and auxiliary materials into the mixer, set the motor operating frequency to 200r / min, and start the mixer to mix for 25 minutes;

[0049] 4) Choose a high-speed tablet press to press the tablet, adjust the pressure so that the tablet can be formed and the hardness is 4-9kgf, and the friability is not more than 1%;

[0050] 5) Packaging.

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Abstract

The invention discloses a cefetamet pivoxil hydrochloride tablet composition, and belongs to the technical field of medicine. The cefetamet pivoxil hydrochloride tablet composition is prepared from cefetamet pivoxil hydrochloride, compressible starch, microcrystalline cellulose 102, sodium starch glycolate, hydroxypropyl cellulose, glyceryl behenate and magnesium stearate. Tests show that tablets prepared from the cefetamet pivoxil hydrochloride tablet composition, compared with the prior art, have the advantages that the macromolecular polymer content is relatively lower and increases a little along with prolonging of storage time, and the stability is high; in addition, the composition has more remarkable antibacterial activity to pneumococcus and hemophilus influenzae, and also has relatively higher antibacterial activity to enterococcus and staphylococcus.

Description

[0001] This application is an invention patent application filed by the applicants Yantai Huawen Xinxin Pharmaceutical Technology Co., Ltd. and Zhao Kongbo (the name of the invention is: a drug composition of ceftazidime pivoxil hydrochloride for the treatment of sensitive bacterial infectious diseases, the application number is: 2015102460574, the application The date is: May 15, 2015). technical field [0002] The invention belongs to the technical field of medicines, and relates to a ceftazidime hydrochloride composition for treating susceptible bacterial infectious diseases, in particular to a ceftazidime hydrochloride tablet composition. Background technique [0003] Ceftazidime pivoxil hydrochloride is a third-generation broad-spectrum cephalosporin antibiotic. After oral administration, it is rapidly hydrolyzed in the body into cefetamet with antibacterial activity to play a bactericidal effect. Ceftazidime hydrochloride has strong antibacterial activity against Gram...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K9/20A61K47/38A61P31/04C07D501/22C07D501/12
CPCA61K9/2013A61K9/2054A61K9/2059A61K31/546A61K47/36A61K47/38C07B2200/13C07D501/04C07D501/12C07D501/22
Inventor 赵孔波
Owner YANTAI HUAWEN XINXIN PHARMA CO LTD
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