Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Granules of cefetamet pivoxil hydrochloride and preparation method thereof

A technology of ceftazime pivoxil hydrochloride and granules, applied in the field of medicine, can solve the problems such as the difficulty in realizing ceftazidime pivoxil, the problem of patient compliance that has not been effectively solved, and the application limitation, so as to achieve improved bioavailability and smooth surface. , the effect of short coating time

Active Publication Date: 2012-10-10
鲁南新时代生物技术有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] These patent documents make dispersible tablets of ceftamet pivoxil hydrochloride, which improves the curative effect of ceftamet pivoxil to a certain extent, but by directly adding flavoring agents in order to achieve the purpose of taste masking, for the extremely bitter ceftazidime For tametexil, it is undoubtedly difficult to achieve, and the problem of patient compliance has not been effectively resolved, so the clinical application of this drug is still limited.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Granules of cefetamet pivoxil hydrochloride and preparation method thereof
  • Granules of cefetamet pivoxil hydrochloride and preparation method thereof
  • Granules of cefetamet pivoxil hydrochloride and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Prescription composition

[0036] (1) Ceftamet pivoxil hydrochloride fine granule prescription:

[0037] Ceftazidime Pixil Hydrochloride 500g

[0038] 600g pregelatinized starch

[0039] Hydroxypropyl Cellulose 150g

[0040] Low-substituted hydroxypropyl cellulose 150g

[0041] Appropriate amount of purified water

[0042] (2) Prescription of coating material:

[0043] Polyvinyl acetal diethylamine acetate 55 parts

[0044] Hypromellose 20 parts

[0045] PEG6000 10 copies

[0046]Magnesium stearate 10 parts

[0047] 5 parts methyl silicone oil

[0048] 5% ethanol water solution

[0049] (3) Prescription of ceftazidime pivoxil hydrochloride granules:

[0050] Ceftazidime pivoxil hydrochloride coated fine granules 70 parts

[0051] 10 parts pregelatinized starch

[0052] Calcium hydrogen phosphate 2 parts

[0053] 8 parts hydroxypropyl cellulose

[0054] Sodium carboxymethyl starch 10 parts

[0055] Appropriate amount of purified water

[0056] ...

Embodiment 2

[0063] 1. Prescription composition

[0064] (1) Ceftazidime pivoxil hydrochloride fine granule prescription

[0065] Ceftazidime Pixil Hydrochloride 500g

[0066] Microcrystalline Cellulose 300g

[0067] Xylitol 100g

[0068] Methylcellulose 50g

[0069] Sodium Carboxymethyl Cellulose 50g

[0070] Appropriate amount of purified water

[0071] (2) Prescription of coating material

[0072] Eudragit E100 60 servings

[0073] Hypromellose 15 parts

[0074] PEG6000 10 copies

[0075] Micropowder silica gel 10 parts

[0076] 3 parts methyl silicone oil

[0077] Appropriate amount of purified water

[0078] (3) Prescription of ceftazidime pivoxil hydrochloride granules:

[0079] Ceftazidime pivoxil hydrochloride coated fine granules 60 parts

[0080] Lactose 10 parts

[0081] 5 parts microcrystalline cellulose

[0082] 10 parts methyl cellulose

[0083] Low-substituted hydroxypropyl cellulose 15 parts

[0084] Appropriate amount of purified water

[0085] ...

Embodiment 3

[0092] 1. Prescription composition

[0093] (1) Ceftazidime pivoxil hydrochloride fine granule prescription

[0094] Ceftazidime Pixil Hydrochloride 500g

[0095] 100g pregelatinized starch

[0096] Mannitol 50g

[0097] Hypromellose 45g

[0098] Low-substituted hydroxypropyl cellulose 55g

[0099] Appropriate amount of purified water

[0100] (2) Prescription of coating material

[0101] Eudragit E100 70 servings

[0102] PEG4000 15 copies

[0103] Magnesium stearate 10 parts

[0104] 5 parts polydimethylsiloxane

[0105] Appropriate amount of purified water

[0106] (3) Prescription of Ceftazidime Pixil Hydrochloride Granules

[0107] Ceftamet pivoxil hydrochloride coated fine granules 50 parts

[0108] Xylitol 20 parts

[0109] Calcium carbonate 5 parts

[0110] 10 parts methyl cellulose

[0111] Low-substituted hydroxypropyl cellulose 15 parts

[0112] Appropriate amount of purified water

[0113] Make 1000 bags

[0114] 2. Prepar...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides granules of cefetamet pivoxil hydrochloride and a preparation method thereof, which belong to the technical field of medicine. The granularity of the granules is 200-1600mu m, and the granules are prepared from fine cefetamet pivoxil hydrochloride coating granules and pharmaceutically acceptable auxiliary materials. The fine cefetamet pivoxil hydrochloride coating granules are obtained by coating after cefetamet pivoxil hydrochloride and auxiliary materials are prepared into fine granules by a spray method of a fluidized bed, wherein the fine cefetamet pivoxil hydrochloride coating granules account for 30-75% of the total weight of the entire granules. A coating material used for coating contains a film-forming material, a plasticizer and an antiblocking agent; the invention has the advantages of completely covering up the special bitter taste of the cefetamet pivoxil hydrochloride and enhancing the application conformability of the aged, children and patients with difficulties in deglutition.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a granule of ceftamet pivoxil hydrochloride and a preparation method thereof. Background technique [0002] Ceftazidime pivoxil hydrochloride is an oral third-generation broad-spectrum cephalosporin antibiotic, mainly used to treat bacterial infections such as upper and lower respiratory tract infections, urinary tract infections and gonorrhea. It has the characteristics of broad spectrum, high efficiency, sensitivity resistance and low toxicity. Compared with similar varieties of cephalexin and cephradine, it has the advantages of stronger antibacterial activity and lower dosage. The product was developed by Roche (Ro 15-8075) and developed by Japan's Takeda Pharmaceutical Company. It was first launched in Mexico in 1992 under the trade name Globocef. This product is a prodrug, and tametexil is the same as other ester-type drugs. It is rapidly absorbed after oral ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/546A61K47/36A61K47/38A61K47/32A61P31/04
Inventor 赵志全郝贵周张庆华
Owner 鲁南新时代生物技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com