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Cefetamet pivoxil hydrochloride capsule and preparation method thereof

A technology for ceftazidime hydrochloride and capsules, which is applied in the field of ceftazidime hydrochloride capsules and their preparation, can solve the problems of great influence on product quality, easy degradation of active ingredients, unstable properties, etc., and achieves good dissolution effect and high solubility Excellent performance and convenient use

Active Publication Date: 2011-02-02
ZHEJIANG YATAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, due to the extremely bitter taste of the ceftazidime pivoxil hydrochloride raw material, the direct production of tablets affects the taste, and the drug users will have a resistance to taking the medicine, so they need to be coated or added with a flavoring agent before taking it. Capsules are a kind of medicine that can cover up the bitter taste Commonly used dosage forms
In addition, ceftametoxo pivoxil hydrochloride raw material drug is relatively viscous. At present, wet granulation is mostly used to improve the fluidity of the drug. However, due to its unstable properties under high temperature and high humidity conditions, the use of wet granulation has a great impact on product quality. Contains active ingredients that are easily degraded

Method used

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  • Cefetamet pivoxil hydrochloride capsule and preparation method thereof
  • Cefetamet pivoxil hydrochloride capsule and preparation method thereof
  • Cefetamet pivoxil hydrochloride capsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039]

[0040] Dry sodium carboxymethyl starch at 120°C for 4 hours, seal it with a double-layer plastic bag and put it in a stainless steel turnover bucket for later use; dry the lactose at 80°C for 4 hours, seal it with a double-layer plastic bag and put it in a stainless steel turnover barrel for later use; After the alcohol is dried at 80°C for 4 hours and passed through an 80-mesh sieve, it is sealed with a double-layer plastic bag and put into a stainless steel turnover bucket for later use.

[0041] Put the above-mentioned dried sodium carboxymethyl starch, lactose and mannitol, croscarmellose sodium, sodium lauryl sulfate and micropowder silica gel into the mixer and pre-mix for 10 minutes. After mixing evenly, add 1 / 2 The prescription amount of ceftazidime pivoxil hydrochloride was premixed for 10 minutes, and then 1 / 2 of the prescription amount of ceftazime pivoxil hydrochloride was added and mixed evenly to obtain a mixed material.

[0042]The above mixed materi...

Embodiment 2

[0045]

[0046] The preparation method is the same as in Example 1.

Embodiment 3

[0048]

[0049] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a cefetamet pivoxil hydrochloride capsule which contains the raw materials by the weight percent: 59% of effective and active ingredient, 10-15% of disintegrant, 1-3% of solubilizer, 20-28% of bulking agent and 2-3% of lubricating agent; wherein the effective and active ingredient is cefetamet pivoxil hydrochloride; the disintegrant comprises sodium carboxymethyl starch and cross-linked sodium carboxyl cellulose; the solubilizer is lauryl sodium sulfate; the bulking agent is one or two of lactose and mannitol; and the lubricating agent includes superfine silica powderand magnesium stearate. The invention also discloses a preparation method of the cefetamet pivoxil hydrochloride capsule, which adopts dry pressing pelletization technique; therefore, the invention has the advantages of simple equipment and less investment; the prepared capsule is stable in quality, excellent in solubility property, rapid in absorption, convenient in taking and good in mouthfeel.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a ceftazidime hydrochloride capsule and a preparation method thereof. Background technique [0002] In today's society, people's living standards are constantly improving, and people pay more attention to medical and health care. β-lactam antibiotics, as a class of antibiotics with the largest clinical dosage, the most widely used, the most varieties, and the best curative effects, are more and more popular among the people. Consumption is increasing year by year. Among them, cephalosporin products accounted for about 70%. [0003] Ceftazidime pivoxil hydrochloride, as a key variety of cephalosporin products, was listed as one of the varieties recommended for research and development during the "Tenth Five-Year Plan" period in my country, and has great market development potential. The tablet of ceftazidime pivoxil hydrochloride was researched and developed by F.Hoffm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K31/546A61K47/38A61K47/36A61P31/04
Inventor 吕旭幸王丽云陈洁
Owner ZHEJIANG YATAI PHARMA
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