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Cefetamet pivoxil hydrochloride slow release tablet

A technology of ceftazidime hydrochloride and sustained-release tablets, which is applied in the directions of non-active ingredient medical preparations, pill delivery, organic active ingredients, etc. , to achieve stable and long-lasting curative effect, better dispersion effect and significant effect.

Inactive Publication Date: 2018-09-25
SICHUAN XINGZHI ZHIHUI INTPROP OPERATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the oral preparation of the prior art, when it is administered, the blood drug concentration of the drug in the lesion is not uniform in different time periods, and there is a peak and a trough of administration, resulting in inconstant drug effectiveness. and lasting

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of ceftazidime hydrochloride slow-release tablet, by weight percentage, comprises:

[0030] 1-4 parts of ceftazidime pivoxil hydrochloride;

[0031] 1-3 parts of microcrystalline cellulose;

[0032] Maltitol 16-20 parts;

[0033] 2-4 parts of beta cyclodextrin;

[0034] 1-3 parts of hydrogenated vegetable oil.

[0035] In this embodiment, the preferred amount of ceftamet pivoxil hydrochloride is 3 parts; the preferred amount of microcrystalline cellulose is 3 parts; the preferred amount of maltitol is 18 parts; the preferred amount of beta cyclodextrin is 3 parts; and the preferred amount of hydrogenated vegetable oil is 2 parts.

[0036] The preparation technology of above-mentioned ceftamet pivoxil hydrochloride buccal tablet is as follows:

[0037] First, uniformly mix ceftazidime pivoxil hydrochloride and hydrogenated vegetable oil according to the proportion, then add microcrystalline cellulose and mix uniformly to form mixture 1;

[0038] Secondly, mix...

Embodiment 2

[0042] The difference between this embodiment and Embodiment 1 is that the specific composition ratio is optimized in this embodiment, and the specific settings are as follows:

[0043] In this embodiment, the preferred amount of ceftamet pivoxil hydrochloride is 4 parts; the preferred amount of microcrystalline cellulose is 2 parts; the preferred amount of maltitol is 20 parts; the preferred amount of beta cyclodextrin is 2 parts; and the preferred amount of hydrogenated vegetable oil is 3 parts.

[0044] The buccal tablet prepared in this example was used to carry out the release test, and the results showed that the release rate was 7% at 0 min, 8% at 3 min, and 8% at 10 min. The dissolution rate is very uniform and the effect is remarkable.

Embodiment 3

[0046] This example is a comparative example. In this example, the sustained-release tablet includes: 4 parts of ceftamet pivoxil hydrochloride; 20 parts of maltitol; 2 parts of beta-cyclodextrin.

[0047] The buccal tablet prepared in this example was used to carry out the release test, and the results showed that the release rate was 8% at 0 min, 23% at 3 min, and 6% at 10 min.

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PUM

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Abstract

The invention discloses a cefetamet pivoxil hydrochloride slow release tablet, which solves the problems that in the prior art, during the oral preparation administration, the blood medicine concentration of the medicine in lesion positions in different time periods is not uniform; a medicine administration wave peak and trough condition exists, so that the medicine effectiveness is not constant and not durable. The cefetamet pivoxil hydrochloride slow release tablet is prepared from 1 to 4 parts of cefetamet pivoxil hydrochloride, 1 to 3 parts of microcrystalline cellulose, 16 to 20 parts ofmaltitol, 2 to 4 parts of betadex and 1 to 3 parts of hydrogenated vegetable oil in parts by weight. The cefetamet pivoxil hydrochloride slow release tablet has the advantages that the medicine effectcan be better released, so that the medicine effect can be uniformly released in the process of being kept in the mouth; the curative effect is more stable and durable.

Description

technical field [0001] The invention relates to an oral sustained-release tablet, in particular to a ceftazidime hydrochloride sustained-release tablet. Background technique [0002] Pharyngitis is the most common disease that plagues the lives of modern people. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, and is often a part of upper respiratory tract infection. Clinically divided into acute and chronic two. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be limited to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections were dominated by Gram-positive cocci such as Streptococcus, Staphylococcus and Diplococcus pneumoniae. Among them, those caused by group A streptococcus are the most serious. Bacteria or toxin...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K47/44A61K47/38A61K47/26A61K47/40A61K31/546A61P31/04
CPCA61K9/2054A61K9/0056A61K9/2013A61K9/2018A61K9/205A61K31/546A61P31/04
Inventor 周豪
Owner SICHUAN XINGZHI ZHIHUI INTPROP OPERATION CO LTD
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