Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cefetamet pivoxil hydrochloride dispersible tablet and preparation method thereof

A technology for ceftazidime hydrochloride and dispersible tablets, applied in the field of medicine, can solve the problems of large volume of capsules, and achieve the effects of high bioavailability, short disintegration time and fast absorption

Inactive Publication Date: 2013-01-30
ZHEJIANG KAIRUN PHARMA
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the technical defects that ordinary tablets and capsules are large in size and not suitable for infants and patients with dysphagia, an object of the present invention is to provide a kind of ceftazidime hydrochloride dispersible tablet, another one of the present invention Purpose is to provide the preparation method of above-mentioned ceftazidime hydrochloride dispersible tablet

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefetamet pivoxil hydrochloride dispersible tablet and preparation method thereof
  • Cefetamet pivoxil hydrochloride dispersible tablet and preparation method thereof
  • Cefetamet pivoxil hydrochloride dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]

[0031]

[0032] As shown in Figure 1, above-mentioned raw material prepares ceftazime pivoxil hydrochloride dispersible tablet according to the following method:

[0033] 1) Pretreatment of raw and auxiliary materials: ceftametexil hydrochloride, microcrystalline cellulose, crospovidone, calcium hydrogen phosphate, sodium carboxymethyl starch, silicon dioxide, magnesium stearate, stevioside all passed 60~ 80 mesh sieve;

[0034] 2) Granulation: Accurately weigh the sieved ceftazidime hydrochloride, crospovidone, and calcium hydrogen phosphate, pour them into a high-efficiency wet mixing granulator, set the stirring frequency to 40Hz, and start stirring and mixing for 3~5min After the mixing is completed, add purified water, set the chopping frequency to 45HZ, start chopping and granulating, and discharge;

[0035] 3) Drying: Spread the wet granules obtained from granulation evenly on the drying pan of the drying car, set the temperature at 50-65°C, and the tota...

Embodiment 2

[0042]

[0043] Above-mentioned raw material prepares ceftazidime hydrochloride dispersible tablet by the method described in embodiment 1.

Embodiment 3

[0045]

[0046] Above-mentioned raw material prepares ceftazidime hydrochloride dispersible tablet by the method described in embodiment 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of a medicine, in particular to a cefetamet pivoxil hydrochloride dispersible tablet and a preparation method of the cefetamet pivoxil hydrochloride dispersible tablet. The cefetamet pivoxil hydrochloride dispersible tablet is prepared by the following components in parts by weight: 40 to 60% of cefetamet pivoxil hydrochloride, 10 to 20% of microcrystalline cellulose, 5 to 15% of polyvinylpolypyrrolidone, 5 to 12% of calcium hydrophosphate and 5 to 15% of carboxymethyl starch sodium. Compared with the ordinary tablet, the cefetamet pivoxil hydrochloride dispersible tablet provided by the invention has the advantages of being good in disperse state, short in disintegration time, high in bioavailability, little in untoward effect, rapid to dissolve the medicines, fast to absorb and convenient to take and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a ceftazidime hydrochloride dispersible tablet and a preparation method thereof. Background technique [0002] Ceftazidime hydrochloride is an oral third-generation cephalosporin drug developed by Swiss Hoffmann Roche Company in the late 1970s. This product was first listed in Mexico in 1992. The name Globocef. [0003] Ceftazidime pivoxil hydrochloride has good antibacterial activity against most Gram-negative bacteria and some positive bacteria, and is stable against a variety of β-lactamases produced by bacteria, with strong tissue penetration and anti-inflammatory ability to the body. Positive regulatory effect. [0004] The active ingredient in ceftazidime pivoxil hydrochloride must be orally hydrolyzed into ceftazime pivoxil to produce antibacterial activity. The dosage forms of the medicine sold in the market are mainly ordinary tablets and capsules. The disintegration and rele...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/546A61P31/04A61P29/00
Inventor 郝晋
Owner ZHEJIANG KAIRUN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com