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Medicinal cefetamet pivoxil hydrochloride composition for treating sensitive bacteria infectious diseases

A technology of ceftamet pivoxil hydrochloride and infectious diseases, applied in the field of ceftamet pivoxil hydrochloride tablet composition, can solve the problems of patient harm, immediate allergic reaction, etc., achieve low polymer content and significant antibacterial activity , strong antibacterial activity

Active Publication Date: 2015-07-29
启东市和洪农副产品专业合作社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, because its basic structure is the same as that of many semi-synthetic β-lactam lactam antibiotics already on the market, ceftazidime hydrochloride will also form high molecular polymers, which will also cause immediate hypersensitivity reactions in clinical use, which is harmful to patients. great

Method used

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  • Medicinal cefetamet pivoxil hydrochloride composition for treating sensitive bacteria infectious diseases
  • Medicinal cefetamet pivoxil hydrochloride composition for treating sensitive bacteria infectious diseases
  • Medicinal cefetamet pivoxil hydrochloride composition for treating sensitive bacteria infectious diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of ceftazidime pivoxil hydrochloride crystal

[0030] Get ceftamet pivoxil hydrochloride crude drug, add the mixed solution that volume is 8 times of ceftamet pivoxil hydrochloride weight diethyl ether and ethanol composition, wherein the volume ratio of diethyl ether and ethanol is 4:2.5, be heated to 30-35 ℃; Hydrochloric acid After the ceftazime pivoxil raw material is dissolved, add activated carbon for decolorization, and filter; the filtrate is heated and kept at a temperature of 35-40°C, and a mixed solvent of dimethylformamide and acetone whose volume is 6 times the weight of ceftamet pivoxil hydrochloride is added dropwise, The volume ratio of dimethylformamide and acetone is 2:1; after dropping, stir and cool down, the stirring and cooling is to cool down to 20-25°C at a speed of 1.5-3.5°C / min under stirring at a speed of 50-75rmp, and then Cool down to 5-10°C at a speed of 0.5-1°C / min under stirring at a speed of 30-45rmp, let stand f...

Embodiment 2

[0032] Example 2: The preparation of ceftazidime pivoxil hydrochloride tablet, step is as follows:

[0033] Prescription: in parts by weight

[0034]

[0035] Preparation:

[0036] 1) Processing of raw and auxiliary materials: Use a vibrating sieving machine to pass compressible starch, microcrystalline cellulose 102, and hydroxypropyl cellulose through a 60-mesh sieve, carboxymethyl starch sodium through a 120-mesh sieve, and ceftazidime pivoxil hydrochloride through a 80-mesh sieve .

[0037] 2) Weighing: Weigh all raw and auxiliary materials according to the prescription;

[0038] 3) Mixing: Add the weighed raw and auxiliary materials into the mixer, set the motor operating frequency to 200r / min, and start the mixer to mix for 25 minutes;

[0039] 4) Choose a high-speed tablet press to press the tablet, adjust the pressure so that the tablet can be formed and the hardness is 4-9kgf, and the friability is not more than 1%;

[0040] 5) Packaging.

Embodiment 3

[0041] Example 3: The preparation of ceftazidime pivoxil hydrochloride tablet, step is as follows:

[0042] Prescription: in parts by weight

[0043]

[0044] Preparation:

[0045] 1) Processing of raw and auxiliary materials: Use a vibrating sieving machine to pass compressible starch, microcrystalline cellulose 102, and hydroxypropyl cellulose through a 60-mesh sieve, carboxymethyl starch sodium through a 120-mesh sieve, and ceftazidime pivoxil hydrochloride through a 80-mesh sieve .

[0046]2) Weighing: Weigh all raw and auxiliary materials according to the prescription;

[0047] 3) Mixing: Add the weighed raw and auxiliary materials into the mixer, set the motor operating frequency to 200r / min, and start the mixer to mix for 25 minutes;

[0048] 4) Choose a high-speed tablet press to press the tablet, adjust the pressure so that the tablet can be formed and the hardness is 4-9kgf, and the friability is not more than 1%;

[0049] 5) Packaging.

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Abstract

The invention discloses a medicinal cefetamet pivoxil hydrochloride composition for treating sensitive bacteria infectious diseases, and belongs to the field of medical technology. The medicinal cefetamet pivoxil hydrochloride composition is prepared from cefetamet pivoxil hydrochloride, compressible starch, microcrystalline cellulose 102, carboxymethyl starch sodium, hydroxypropylcellulose, glyceryl behenate and magnesium stearate. Experiments discover that compared with the prior art, the tablet prepared by novel crystal type compound of the cefetamet pivoxil hydrochloride is relatively low in high-molecular polymer content and good in stability; the increasing of the content of the high-molecular polymer is quite few with the increasing of storage time; meanwhile, the composition has more remarkable antimicrobial activity on pneumococcus and hemophilus influenzae as well as has relatively strong antimicrobial activity on enterococcus and staphylococcus.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a ceftazidime hydrochloride composition for treating susceptible bacterial infectious diseases, in particular to a ceftazidime hydrochloride tablet composition. Background technique [0002] Ceftazidime pivoxil hydrochloride is a third-generation broad-spectrum cephalosporin antibiotic. After oral administration, it is rapidly hydrolyzed in the body into cefetamet with antibacterial activity to play a bactericidal effect. Ceftazidime hydrochloride has strong antibacterial activity against Gram-positive bacteria such as Streptococcus (except for Streptococcus faecalis), Pneumococcus, Escherichia coli, Klebsiella, influenza bacilli, and Neisseria gonorrhoeae, especially Serratia spp., indole-positive Proteus spp., Enterobacter spp. and Citrobacter spp. with low sensitivity to cephalosporins had obvious antibacterial activity. Stable against bacterially produced β-lactamases. Cef...

Claims

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Application Information

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IPC IPC(8): A61K31/546C07D501/22C07D501/04A61P31/04
CPCA61K9/2013A61K9/2054A61K9/2059A61K31/546A61K47/36A61K47/38C07B2200/13C07D501/04C07D501/12C07D501/22
Inventor 常俊敏
Owner 启东市和洪农副产品专业合作社
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