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Anti-infective drug cefetamet pivoxil hydrochloride composite capsule

A technology of ceftazime pivoxil hydrochloride and a composition, which is applied in the field of anti-infective drug ceftazime pivoxil hydrochloride composition capsules, can solve the problems of patient harm, immediate allergic reaction, etc., achieves low polymer content, significant antibacterial Active and low impurity content

Inactive Publication Date: 2015-11-11
QINGDAO HUAZHICAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, because its basic structure is the same as that of many semi-synthetic β-lactam lactam antibiotics already on the market, ceftazidime hydrochloride will also form high molecular polymers, which will also cause immediate hypersensitivity reactions in clinical use, which is harmful to patients. great

Method used

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  • Anti-infective drug cefetamet pivoxil hydrochloride composite capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Preparation of ceftazidime pivoxil hydrochloride crystal

[0034] 1) Prepare mixed solution A by mixing dimethylformamide and water at a volume ratio of 4:1;

[0035] 2) Take ceftazidime pivoxil hydrochloride raw material, add the mixed solution A prepared in step 1), wherein the ratio of the volume of the mixed solution A to the mass of ceftazime pivoxil hydrochloride is 8ml:1g, stir to dissolve all Add 0.1% g / ml activated carbon to the resulting solution for decolorization and filtration to obtain a clear solution;

[0036] 3) Prepare mixed solution B with isopropyl ether and isopropanol at a volume ratio of 3.5:1;

[0037] 4) At room temperature, add mixed solution B to the clear solution obtained in step 2) under an ultrasonic field with a power of 0.6KW, where the amount of mixed solution B added is 7 times the volume of mixed solution A, and turn off the ultrasonic field after adding , cooled to 3° C., allowed to stand for 2 hours, crystals were pre...

Embodiment 2

[0039] Example 2: The preparation of ceftazime pivoxil hydrochloride capsules, the steps are as follows:

[0040] Prescription: in parts by weight as shown in Table 1

[0041] Table 1 Ceftazidime hydrochloride composition prescription

[0042]

[0043] Preparation:

[0044] 1) Processing of raw and auxiliary materials: use a vibrating sieving machine to pass microcrystalline cellulose and magnesium aluminum silicate through a 60-mesh sieve, and ceftazidime pivoxil hydrochloride through a 80-mesh sieve;

[0045] 2) Weighing: Weighing according to the prescription;

[0046] 3) Adhesive preparation: Add povidone K30 into absolute ethanol, stir to dissolve evenly, and set aside;

[0047] 4) Granulation: Add ceftazidime pivoxil hydrochloride, microcrystalline cellulose, and magnesium aluminum silicate to the wet granulator, turn on the stirring motor and dry mix for 5 minutes, add povidone K30 ethanol solution, wet mix and cut 100- 150 seconds to make soft material, 18-mes...

Embodiment 3

[0052] Example 3: The preparation of ceftazime pivoxil hydrochloride capsules, the steps are as follows:

[0053] Prescription: in parts by weight as shown in Table 2

[0054] Table 2 Ceftazidime hydrochloride composition prescription

[0055]

[0056] Preparation:

[0057] 1) Processing of raw and auxiliary materials: use a vibrating sieving machine to pass microcrystalline cellulose and magnesium aluminum silicate through a 60-mesh sieve, and ceftazidime pivoxil hydrochloride through a 80-mesh sieve;

[0058] 2) Weighing: Weighing according to the prescription;

[0059] 3) Adhesive preparation: Add povidone K30 into absolute ethanol, stir to dissolve evenly, and set aside;

[0060] 4) Granulation: Add ceftazidime pivoxil hydrochloride, microcrystalline cellulose, and magnesium aluminum silicate to the wet granulator, turn on the stirring motor and dry mix for 5 minutes, add povidone K30 ethanol solution, wet mix and cut 100- 150 seconds to make soft material, 18-mes...

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Abstract

The invention discloses an anti-infective drug cefetamet pivoxil hydrochloride composite capsule and belongs to the technical field of drugs. A composite is prepared from cefetamet pivoxil hydrochloride, microcrystalline cellulose, magnesium aluminum silicate, povidone K30, anhydrous ethanol and magnesium stearate. The cefetamet pivoxil hydrochloride is a new crystal type compound. An X-ray powder diffraction diagram obtained through Cu-K alpha ray measurement is shown in figure one. The cefetamet pivoxil hydrochloride is different from cefetamet pivoxil hydrochloride reported in the prior art. As is found in experiments, the capsule prepared from the cefetamet pivoxil hydrochloride new crystal type compound is low in high-molecular polymer content and good in stability, and the content of high-molecular polymers is little increased along with prolonging of storage time. Meanwhile, the composite has more remarkable antibacterial activity on pneumococcus and hemophilus influenzae and also has high antibacterial activity on enterococcus and staphylococcus.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to an anti-infection drug ceftazidime pivoxil hydrochloride composition capsule. Background technique [0002] Ceftazidime pivoxil hydrochloride is a third-generation broad-spectrum cephalosporin antibiotic. After oral administration, it is rapidly hydrolyzed in the body to cefetamet with antibacterial activity to play a bactericidal effect. Ceftazidime hydrochloride has strong antibacterial activity against Gram-positive bacteria such as Streptococcus (except for Streptococcus faecalis), Pneumococcus, Escherichia coli, Klebsiella, influenza bacilli, and Neisseria gonorrhoeae, especially Serratia spp., indole-positive Proteus spp., Enterobacter spp. and Citrobacter spp. with low sensitivity to cephalosporins had obvious antibacterial activity. Stable to β-lactamases produced by bacteria. Ceftazidime hydrochloride is ineffective against Pseudomonas, Mycoplasma, Chlamydia, Enteroco...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/546A61P31/04C07D501/22C07D501/12
Inventor 张纪云
Owner QINGDAO HUAZHICAO PHARMA CO LTD
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