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Dispersible tablet containing antipsychotic medicines and application thereof

An antipsychotic and dispersible tablet technology, which can be used in medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., and can solve the problem that the pathogenesis of depression is not completely clear.

Inactive Publication Date: 2011-06-01
王定豪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The pathogenesis of depression is not fully understood

Method used

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  • Dispersible tablet containing antipsychotic medicines and application thereof
  • Dispersible tablet containing antipsychotic medicines and application thereof
  • Dispersible tablet containing antipsychotic medicines and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] Embodiment 1: Aripiprazole Dispersible Tablets

[0125] Name of raw material

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Dose 4(mg)

Aripiprazole

5.00

10.00

15.00

20.00

microcrystalline cellulose

15.00

30.00

45.00

60.00

Mannitol

19.87

39.74

79.48

158.96

Sucralose

0.25

0.50

0.75

1.00

Povidone K30

5.00

10.00

15.00

20.00

Sodium dodecyl sulfate

0.50

1.00

1.50

2.00

sodium starch glycolate

2.50

5.00

7.50

10.00

Magnesium stearate

1.50

3.00

4.50

6.00

Micropowder silica gel

0.33

0.66

0.99

1.32

Strawberry Powder Flavor

0.05

0.10

0.15

0.20

Sheet weight

50.00

100.00

150.00

200.00

[0126] Preparation:

[0127] (A) Micronize the main ingredient after drying, and control...

Embodiment 2

[0132] Embodiment 2: fluvoxamine maleate dispersible tablet

[0133] Name of raw material

Embodiment 3

[0134] Embodiment 3: Escitalopram Oxalate Dispersible Tablets

[0135] Name of raw material

[0136] sodium starch glycolate

[0137] ※6.39mg of escitalopram oxalate is equivalent to 5.00mg of escitalopram.

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Abstract

The invention relates to a novel dispersible tablet which is prepared from a certain amount of antipsychotic medicines or pharmaceutically acceptable salt or ester thereof or mixture thereof, a certain amount of selective serotonin reuptake inhibitors (SSRIs) and at least one of pharmaceutically acceptable carriers, wherein the antipsychotic medicines are aripiprazole, fluvoxamine, escitalopram, olanzapine, mirtazapine, clozapine, ziprasidone, mianserin, agomelatine, lurasidone, iloperidone, blonanserin, moclobemide, timiperone, palipeddone, trimipramine, carpipramine, lofepramine or mosapramine. The novel dispersible tablet is used for preventing, delaying or treating depression or schizophrenia of patients. Compared with common tablets or capsules, the novel dispersible tablet has the characteristics of quick and uniform dispersion, short disintegration time, quick medicine absorption, high bioavailability and good stability, and is convenient to take.

Description

technical field [0001] The present invention relates to a novel dispersible tablet, which consists of a certain amount of antipsychotic drugs or their pharmaceutically acceptable salts or esters or their mixtures and optionally a certain amount of serotonin reuptake inhibitors or their pharmaceutically acceptable An acceptable salt or ester or a mixture thereof and at least one pharmaceutically acceptable carrier is used for treating or preventing depression or schizophrenia in a patient, and belongs to the technical field of medicine. Background technique [0002] According to the statistics of the World Health Organization in 2005, the prevalence of various depressions accounts for about 11% of the global population. In China, the current prevalence of depression is about 3% to 5%, and there are estimated to be 36 million people with depression. In stark contrast to the high incidence, the current recognition rate of depression in hospitals above the prefectural level acro...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K45/06A61K31/5513A61K31/496A61K31/343A61K31/15A61P25/18A61P25/24A61K31/138
CPCA61K31/5513
Inventor 王定豪
Owner 王定豪
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