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Preparation method of mianserin tablet

A technology of lin tablet and mianserin is applied in the field of preparation of mianserin tablets, which can solve the problems of loss, many components of traditional Chinese medicine, increase the difficulty of obtaining raw materials, etc., and achieves low cost, components and contents. Reasonable and clear pharmacological effects

Inactive Publication Date: 2018-08-10
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Both CN201510336203 and CN201510336115 use western medicine mianserin hydrochloride as the main supplement and Chinese herbal medicine to make compound medicine to treat depression, which reduces the side effects and dependence produced by western medicine, and has remarkable curative effect. The difficulty of obtaining, and once one or a few kinds of raw materials are in short supply, the enterprise will stop production, resulting in greater losses

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of mianserin tablets, which comprises the following steps:

[0022] Preparation of ginseng extract: put the ginseng into a pulverizer, smash it through a 50-mesh sieve, then add it to 10 times the weight of water, heat to 70°C, keep it warm for 1 hour, and collect the filtrate; place the filtrate in a vacuum concentrator, vacuum Concentrate to one-third of the volume of the filtrate; add alcohol to make the alcohol content in the concentrate reach 75% (v / v), let stand for 1 hour, filter and collect the filtrate, the filtrate is obtained by rotary evaporation under reduced pressure to remove the ethanol and dry at low temperature. Ginseng extract; the content of saponin compounds is 73.6%;

[0023] Prepare Rehmannia glutinosa extract: take Rehmannia glutinosa, cut into pieces, add 10 times the weight of water to soak for 60 minutes, and then ultrasonically extract for 30 minutes. The intensity of the ultrasonic waves is 25kHz, filtered, and the filtrate i...

Embodiment 2

[0034] Acute toxicity test: First, dissolve the tablet prepared in Example 1 in physiological saline, stir evenly, and control the concentration at 0.5 mg / mL. Forty Kunming mice, half male and half male, were selected for acute toxicity test. The mice were randomly divided into two groups with 20 mice in each group. The mice were fasted for 12 hours before the experiment and were given the liquid medicine prepared in Example 1 by gavage. The control group was given the same amount of normal saline at 25ml / kg; The drug was administered twice, and the mice were continuously observed for two weeks after the administration, and the toxicity and the number of deaths of the mice were recorded. The experimental results showed that: compared with the control group, there was no significant difference in the mice after the administration. The experiment was observed for two consecutive weeks, and the mice's general condition, diet, drinking water, and weight gain were no obvious abnorma...

Embodiment 3

[0037] Test animal: Kunming mouse, male, weighing 20±2g.

[0038] 1. Forced mice to swim experiment

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PUM

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Abstract

The invention belongs to the technical field of medicines and discloses a preparation method of a mianserin tablet. The preparation method comprises the following steps: firstly, preparing a panax ginseng extract; secondly, preparing a radix rehmanniae extract; thirdly, granulating, finishing, tabletting and coating with a film. According to the preparation method disclosed by the invention, components and the content of a formula are reasonable; two Chinese herbal extracts are added to be matched with mianserin hydrochloride, so that the medicinal efficacy is improved; meanwhile, the dose ofmianserin can be reduced according to the medicinal efficacy, and toxic or side effects generated by western medicine are reduced.

Description

Technical field [0001] The invention belongs to the technical field of medicine preparation, and specifically relates to a preparation method of mianserin tablets. Background technique [0002] Depression or depressive disorder is a major global mental health problem. Its etiology is complex and has not yet been fully elucidated. With the increasing competition in modern society, people’s psychological pressure continues to increase, and emotional diseases have become the main contemporary diseases. The Health Organization pointed out that the biggest disease facing people in the 21st century is mental illness. WHO estimates that there are between 120 million and 200 million people suffering from depressive diseases in the world. In 1996, a survey on the "burden of disease" published by the WHO showed that: in terms of disability due to illness (functional impairment), depression ranked second, accounting for 6.2% of the total burden of disease. Such patients are depressed, slo...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/28A61P25/24A61K31/55
CPCA61K31/55A61K9/28A61K36/258A61K36/804A61K2236/331A61K2236/51A61K2236/53A61K2236/55A61P25/24A61K2300/00
Inventor 林祥宇徐步玺李宁
Owner 仁和堂药业有限公司
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