48 results about "Ibuprofen Injection" patented technology

The invention relates to an ibuprofen injection, which comprises ibuprofen and one or a plurality of alkaline cosolvents pharmaceutically acceptable selected from anhydrides or hydrates of sodium carbonate, sodium bicarbonate,sodium citrate, sodium citrate, sodium phosphate, disodium dihydrogen pyrophosphate, sodium tartrate and sodium acetate. The invention also relates to a preparation method of the ibuprofen injection.

The invention discloses a method for preparing an ibuprofen injection, which is characterized in that the injection is a more stable injection prepared from ibuprofen and an alkaline cosolvent, wherein the cosolvent is one or more of arginine, lysine, histidine, anhydrous ethylenediamine, diethanol amine, and the like. The process has the advantages of simple operation and easy application and is easy for industrialized scale production.

The invention relates to ibuprofen injection and a preparation method thereof. The ibuprofen injection comprises 0.5 to 20 weight percent of ibuprofen, 10 to 60 weight percent of cyclodextrin or cyclodextrin derivatives, 1 to 40 weight percent of water soluble excipient and the balance of water, wherein ibuprofen serves as a main medicament; and the cyclodextrin or cyclodextrin derivatives and the water soluble excipient serve as medicinal auxiliary materials. In the invention, the cyclodextrin or cyclodextrin derivatives represented by hydroxypropyl-beta-cyclodextrin is used to make the ibuprofen, which used to be water insoluble, very water soluble. The stability of the medicament is improved. The clathrate compounds can be made into injection using water as a solvent or power for injection. Thus, it is very convenient to administrate the medicament in clinic and it is easy to control injection volume. Meanwhile, the drawback of the universal adoption of auxiliary materials and solvents for injection, which are very dangerous, such as organic solvents and cosolvents, of the conventional insoluble and soluble medicinal injection is overcome.

The invention provides anibuprofenlyophilized powder composition and a preparation method. The ibuprofenlyophilized powder composition comprises ibuprofen,a solubilizer arginine and sodium chloride of a stabilizer. The problems of instability of an existing ibuprofeninjection and related substance increase are solved; and the compliance of a patient is improved.

The invention relates to an ibuprofen injection. The injection consists of an active component ibuprofen and a cosolvent arginine, and is characterized in that the molar ratio of ibuprofen to arginine is 1:1.08-1.12, pH conditioning agents are not used, the amount and kind of accessories during injection preparation are reduced, irritation is low and security is higher. The prepared ibuprofen injection is substantially improved in resistance of high temperature and hard light; not only insoluble particles are obviously minimized, but also the compatibility problems of the injection with common salt and glucose injections are solved; and the product quality stability is substantially improved, and clinic compatibility demands are satisfied. Also, the invention provides a preparation method which is simple in technology and suitable for industrialized production.

The invention relates to a proportioning method of ibuprofen injection liquid, a preparation process and relevant substance limitation and belongs to the technical field of medicine. The medical auxiliary materials of the injection liquid are arginine, the injection liquid is prepared by mixing the ibuprofen and arginine according to a mol ratio, the total quantity of relevant substances in the injection liquid is lower than 0.5 percent, and in addition, the content of each kind of impurities is respectively lower than 0.1 percent. The pH value of the injection liquid is controlled in a range that the ibuprofen can be completely dissolved, and the crystal separation phenomenon cannot occur. The content of relevant substances of the injection liquid is strictly controlled in a certain range so that the adverse effect generated on human bodied is avoided to the furthest degree during the intravenous drip on patients, and the safety is higher. The ibuprofen injection liquid provided by the invention has the advantages that the preparation process is simple, the operation is easy, the efficiency is high, and products with stable quality can be prepared.

The invention discloses an ibuprofen injection composite which can obviously improve the quality stability of products and meet the clinical compatibility demand and a preparation method thereof to overcome the defect of the traditional ibuprofen injection. The injection is prepared by mixing ibuprofen and cosolvent according to a molar ratio of 1: 1.001-2, and the pH value of the injection is 7.5-9.0. The ibuprofen injection prepared through the method has obviously improved tolerance capability to high temperature and strong light and better stability and no irritant to vessels, and can effectively meet the requirement of the clinical intravenous drip. Moreover, the preparation method of the invention has the advantages of simple process and good stability of the prepared product.

The invention relates to an ibuprofen injection. A prescription of the injection comprises a main drug ibuprofen and a cosolvent arginine, the dose of arginine in the prescription is 83.75 mg / ml-95 mg / ml, the molar ratio of the arginine to the ibuprofen is 0.99:1-1.18:1, and the pH value range of the injection is 7.8-8.8. The prepared product is superior to the prior art in quality and has good stability and safety.

The invention discloses application of ibuprofen to preparation of antitumor drugs, especially application of an ibuprofen injection with a specific concentration (10% to 19%) to treatment of pancreatic cancer, etc. Conventionally, ibuprofen is only used as a drug for relieving fever, easing pain and the like; the results of scientific experiments in the invention prove that ibuprofen has antineoplastic activity; research results have been applied to treatment of patients with tumors, and obvious curative effect is obtained; so theoretical bases and actual cases are provided for application and clinical promotion of ibuprofen in preparation of antitumor drugs.

The invention relates to an ibuprofen injection, which comprises ibuprofen and one or a plurality of alkaline cosolvents pharmaceutically acceptable selected from anhydrides or hydrates of sodium carbonate, sodium bicarbonate,sodium citrate, sodium citrate, sodium phosphate, disodium dihydrogen pyrophosphate, sodium tartrate and sodium acetate. The invention also relates to a preparation method of the ibuprofen injection.