The invention discloses a medicine powder grinding device for capsule tablet preparation. The medicine powder grinding device comprises a base, a rack, a grinding box, a driving motor, a semi-gear, a collision head, a grinding head, a preliminary grinding cavity and exquisite grinding cavities; the other end of a fixed support is fixedly provided with the driving motor, an output shaft of the driving motor is forward, the semi-gear is installed on the output shaft of the driving motor in an interference fit manner, a grinding shaft is installed at a gear core in an interference fit manner and extends into the preliminary grinding cavity, the grinding head is installed in the preliminary grinding cavity, a screen net is connected to the interior of the grinding box through a neck, and the two exquisite grinding cavities are further arranged inside the grinding box. According to the grinding device, the collision head is arranged, and therefore medicine powder can be effectively prevented from adhering to the inner wall of the grinding box; through left-right movement of the grinding box, the medicine powder screening speed is increased; and meanwhile, through the arrangement of the preliminary grinding cavity and the exquisite grinding cavities, medicine powder grinding is more sufficient, and the human body absorbing speed after a tablet is taken by a patient is increased.