Application of ibuprofen to preparation of antitumor drugs

An anti-tumor drug, tumor technology, applied in anti-tumor drugs, drug delivery, drug combination and other directions, can solve the problem of no clinical application precedent of ibuprofen anti-tumor therapy and so on

Inactive Publication Date: 2018-06-22
杨韶彰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on whether ibuprofen can induce apoptosis of cancer cells at home and abroad, and there is no precedent for clinical application of ibuprofen for anti-tumor therapy

Method used

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Examples

Experimental program
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Effect test

example 1

[0014] Huang suffered from pleural metastases and pleural effusion 2 years after pancreatic cancer surgery. Cytological examination of pleural effusion showed cancer cells. After pleural perfusion therapy with 19% ibuprofen injection (500ml / time, twice a day, for 3 to 5 consecutive days), the cancer The cells disappeared, and the pleural effusion was controlled for 5 months (up to CR), without any side effects.

[0015] Clinical case 2

[0016] Zhang had advanced pancreatic cancer, with pleural metastases and pleural effusion formation. Cytological examination of pleural effusion showed cancer cells. After pleural perfusion therapy with 19% ibuprofen injection (500ml / time, twice a day, for 3 to 5 consecutive days), the cancer cells Disappeared, pleural effusion was controlled for more than 2 months (up to CR), without any side effects.

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PUM

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Abstract

The invention discloses application of ibuprofen to preparation of antitumor drugs, especially application of an ibuprofen injection with a specific concentration (10% to 19%) to treatment of pancreatic cancer, etc. Conventionally, ibuprofen is only used as a drug for relieving fever, easing pain and the like; the results of scientific experiments in the invention prove that ibuprofen has antineoplastic activity; research results have been applied to treatment of patients with tumors, and obvious curative effect is obtained; so theoretical bases and actual cases are provided for application and clinical promotion of ibuprofen in preparation of antitumor drugs.

Description

technical field [0001] The invention relates to a new application of ibuprofen, in particular to the application of ibuprofen in the preparation of antitumor drugs. Background technique [0002] At present, in anti-tumor research, inducing the apoptosis of cancer cells is an important way. Promoting tumor cell apoptosis can achieve the purpose of tumor shrinkage and cancer regression. For example, traditional anti-tumor drugs cisplatin and melphalan can all Stimulates the mitochondrial apoptotic pathway in cells, triggering apoptosis. This method has obvious advantages over the treatment method of killing tumor cells, because if anti-tumor drugs can induce the apoptosis of tumor cells in large quantities and activate their own programmed death process, it will avoid the release of tumor cells due to a large number of necrotic cells. Various side effects caused by intracellular substances can reduce the damage of chemotherapy to normal cells and prolong the survival of patie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K9/08A61P35/00
CPCA61K31/192A61K9/0019A61K9/08
Inventor 杨韶彰
Owner 杨韶彰
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