Ibuprofen injection and its preparation method

A technology for injection and water for injection, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of not seeing other ingredients

Inactive Publication Date: 2012-06-13
通辽市华邦药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the technical secret of customer service ibuprofen being oxidized in injection has not been reported, and the original research company of ibuprofen injection——Cumberland Company has applied for a patent for the solubility technology, the patent number is: CN01823764.9 and for its No mention of oxidation
Although the US FDA requires that all excipient ingredients must be disclosed in the drug instructions, only ibuprofen and arginine can be seen in the instructions of ibuprofen injection, and no other ingredients are seen

Method used

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  • Ibuprofen injection and its preparation method
  • Ibuprofen injection and its preparation method
  • Ibuprofen injection and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 5% ibuprofen by weight is added to the water for injection, and arginine equimolar to the ibuprofen is added, and the oxygen content is 3.2% after the nitrogen filling is completed.

Embodiment 2

[0036] 10% by weight of ibuprofen is added to the water for injection, and arginine equal to the mole of ibuprofen is added, and finally the oxygen content is 2.4% after nitrogen filling is completed.

Embodiment 3

[0038] 15% by weight of ibuprofen is added to the water for injection, and arginine equal to the mole of the ibuprofen is added, and finally the oxygen content is 1.3% after nitrogen filling is completed.

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PUM

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Abstract

The invention provides a method for stabilizing ibuprofen injections, as well as an ibuprofen injection prepared by the method. The main points of the method lie in that nitrogen gas is introduced one or repeatedly during preparation for expelling the oxygen in an enclosed packing container, and finally the oxygen content inside the enclosed container is controlled at 0-3%, thus reaching the purpose of avoiding oxidizing ibuprofen.

Description

Technical field: [0001] A method for stabilizing ibuprofen injection and the ibuprofen injection obtained by the method. Background technique: [0002] Ibuprofen, whose chemical name is α-methyl-4-(2-methylpropyl)phenylacetic acid. [0003] Its chemical structural formula: [0004] [0005] The concrete application of ibuprofen clinically has (1) being used for the treatment of orthopedics common disease. Ibuprofen is ideal for pain caused by rheumatic and rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, etc. (2) Analgesia. Ibuprofen has a good effect on chronic dull pain such as headache, toothache, joint pain, muscle pain and dysmenorrhea. And low toxicity, non-addictive. (3) antipyretic. Ibuprofen can lower the body temperature of febrile patients to normal, but has no significant effect on normal body temperature. (4) Others. Ibuprofen is also used to treat cerebral vasospasm, acute lung injury, patent ductus arteriosus in premature infants,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/192A61K47/16A61P29/00
Inventor 闫志刚张曦赜杨秀伟马向霞
Owner 通辽市华邦药业有限公司
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