33results about How to "Meet the needs of clinical medicine" patented technology

The invention discloses an ibuprofen injection composite which can obviously improve the quality stability of products and meet the clinical compatibility demand and a preparation method thereof to overcome the defect of the traditional ibuprofen injection. The injection is prepared by mixing ibuprofen and cosolvent according to a molar ratio of 1: 1.001-2, and the pH value of the injection is 7.5-9.0. The ibuprofen injection prepared through the method has obviously improved tolerance capability to high temperature and strong light and better stability and no irritant to vessels, and can effectively meet the requirement of the clinical intravenous drip. Moreover, the preparation method of the invention has the advantages of simple process and good stability of the prepared product.

The invention discloses etimicin sulfate preparation and its preparing method which comprises, charging acids or alkali as pH conditioning agent so as to increase the dissolving degree of the etimicin, charging right amount of isoosmotic adjustment agent, thus resulting the action of quick sterilization.

The invention discloses methanesulfonic acid doxazosin controlling releasing tablets and a process for preparation, which contains a single-layer core, insoluble semi-permeable membrane, single drug-releasing eyelet on each side of the tablet, and depends on the osmotic pressure difference between inside and outside of the semi-permeable membrane medium. The invention realizes the control of linear releasing of methanesulfonic acid doxazosin by single-layer core structure, and can remain effective and steady blood and drug concentration. The curative effect is improved, the generation rate of side effect is reduced, and the productive technology is greatly simplified.

The invention provides a positive ion lipid nanometer particle / DNA compound and a preparation technology thereof. The preparation technology comprises the following steps that (1) a positive ion lipidmaterial is dissolved in absolute ethyl alcohol through heating; (2) an ethyl alcohol solution prepared in the step (1) is added to an aqueous phase solution dropwise, and positive ion lipid nanometer particles are formed through self-assembling; (3) residue ethyl alcohol in the positive ion lipid nanometer particles of the step (2) is removed; (4) filtering is carried out; (5) a DNA solution isprepared; (6) the prepared positive ion lipid nanometer particles in the step (4) and the DNA solution prepared in the step (5) are mixed according to a certain weight ratio to form the positive ion lipid nanometer particle / DNA compound; and (7) filtering is carried out. According to the preparation technology of the positive ion lipid nanometer particle / DNA compound, the operation of the preparation method is easy and rapid, the particle diameter of the prepared positive ion lipid nanometer particle / DNA compound is 50-150 nm, PDI<0.3, the positive ion lipid nanometer particle / DNA compound isdistributed in a mono-dispersion mode, the structure is stable, the compound is subjected to filtering sterilization at a terminal, and the security of the compound in clinic application of preparation of tumor curing medicine is effectively ensured.

The invention discloses a method for increasing the yield of paclitaxel in an endophytic fungus fermentation product. The method comprises the steps that an endophytic fungus seed solution for producing paclitaxel is inoculated into an endophytic fungus solid state fermentation medium containing taxus media and valeriana jatamansi for culture, the mixture is then put into an alternating magnetic field environment for further culture, and a endophytic fungus solid state fermentation product is obtained; then the endophytic fungus seed solution for producing paclitaxel is inoculated into a liquid fermentation medium containing the endophytic fungus solid state fermentation product for culture, and the final endophytic fungus fermentation product is obtained. According to the method, raw materials are natural, no pollution is caused to the environment, a cycle is short, the yield is high, the method is suitable for industrial production, and compared with a common endophytic fungus fermentation product, the yield of paclitaxel in the endophytic fungus fermentation product is obviously increased.

The invention relates to an injection using astragalus root glycosides extract as the active ingredient, which also comprises pharmaceutically acceptable adjunct for injection, the content of the astragalus root glycosides in the total astragalus root extract is 80-100%, each unit of the preparation contains astragalus root glycosides 90-300mg.

The invention discloses a pharmaceutical preparation containing temozolomide or pharmaceutically acceptable salts or other derivatives thereof, at least one water-based diluent and at least one cosolvent which is sufficient to substantially dissolve the temozolomide or pharmaceutically acceptable salts or other derivatives thereof and a preparing process thereof, and in particular, discloses the freeze-dried preparation containing the temozolomide.

The invention discloses a compound composition of irbesartan and hydrochlorothiazide. The composition can be made into granules, capsules, tablets and coated tablets. By screening and adopting a specific adhesive, the dissolution rate of the active ingredient irbesartan can exceed 94%, and the dissolution rate of hydrochlorothiazide can exceed 96%; after the composition is placed for 10 days at a high temperature of 60 DEG C, the dissolution rates of the two active ingredients are basically kept unchanged; and therefore, the composition has good stability and can meet the needs of clinical medication.

The invention provides a salicylic acid-containing capsaicin ester derivative with a general structural formula I and a preparation method thereof. The derivative has anti-inflammatory, analgesic, anti-cancer, antibacterial and hypolipidemic aspect applications.

The invention discloses a doxazosin mesylate sustained release tablet and a preparation method thereof. The doxazosin mesylate sustained release tablet contains doxazosin mesylate and pharmaceutically acceptable auxiliary materials, and comprises a tablet core and a sustained release coating, wherein the tablet core comprises a hydrophilic gel framework material and an acidifying agent, the hydrophilic gel framework material accounts for 5-25 percent, and the acidifying agent accounts for 10-30 percent; and the weight of the sustained coating layer is 1-5 percent of that of the tablet core. The prepared doxazosin mesylate sustained release tablet can well control release of doxazosin mesylate, has similar release curves to 'cardura XL' in different dissolution media, is not interfered and influenced by the pH of stomach and intestine, enables the plasma concentration to be stable, eliminates a peak-valley phenomenon, effectively reduces side effects and the dosage frequency, improves the compliance of patients and meets the clinical medication requirements.

The invention provides a nicotinic acid-containing capsaicin ester derivative with a general structural formula I and a preparation method thereof. The derivative has analgesic, anti-tumor, anti-inflammatory, anti-atherosclerosis, hypolipidemic, appetite promoting, digestion improving, antibacterial and insecticide, anti-oxidant, anti-viral applications.

The invention discloses an ibuprofen injection composite which can obviously improve the quality stability of products and meet the clinical compatibility demand and a preparation method thereof to overcome the defect of the traditional ibuprofen injection. The injection is prepared by mixing ibuprofen and cosolvent according to a molar ratio of 1: 1.001-2, and the pH value of the injection is 7.5-9.0. The ibuprofen injection prepared through the method has obviously improved tolerance capability to high temperature and strong light and better stability and no irritant to vessels, and can effectively meet the requirement of the clinical intravenous drip. Moreover, the preparation method of the invention has the advantages of simple process and good stability of the prepared product.

The invention provides a carbinoxamine maleate oral slow-release suspension which is prepared from impregnated carbinoxamine maleate-resin composite particles and a suspension matrix. The impregnatedcarbinoxamine maleate-resin composite particles are prepared by using an impregnating agent to impregnate a carbinoxamine-maleate-resin compound and performing wet-process granulation, and the impregnating agent comprises a slow-release material and a plasticizer. The invention further provides a preparation method of the suspension. The preparation method is simple; a novel administration systemtaking sodium polystyrene sulfonate as a carrier is adopted, medicine is combined with sodium polystyrene sulfonate, and the objectives of slow release and taste masking are achieved after impregnating through the impregnating agent and wet-process granulation.

A dispersing tablet of Yixintong is prepared from the micropowdered Yixintong, lactose, microcrystalline cellulose, polyvinyl pyrrolidone, sodium laurylsulfate and carboxymethyl starch sodium through mixing, pulverizing, adding magnesium stearate and residual carboxymethyl starch sodium, stirring and die pressing.

The invention discloses a polydatin-containing composition and application thereof, belongs to the technical field of polydatin application, and aims to solve the technical problem that the solubility of polydatin in pure water or a normal saline solution is limited. The polydatin-containing composition adopts composite hydrogel as a drug carrying agent, so that the solubility of polydatin in an aqueous solution or the normal saline solution is improved, and the polydatin-containing composition meets the clinical medication requirements of polydatin; and according to the composite hydrogel, the reverse reversible thermal gelling property of poloxamer is utilized, silk fibroin and carboxymethyl chitosan are introduced, carboxyl on the carboxymethyl chitosan reacts with amino on the silk fibroin and hydroxyl on the poloxamer at the same time, an interpenetrating network is formed in a composite gel system, the mechanical strength of the composite hydrogel is improved, and hydrophilic chain segments of the silk fibroin and the poloxamer exist in the whole gel system, so that the gel-sol transition temperature tends to body temperature, and the composite hydrogel is suitable for human body administration.

The invention provides a class of capsaicin-containing salicylate derivatives with general structural formula I and a preparation method thereof, and the derivatives have the uses of anti-inflammation, labor pain, anti-cancer, antibacterial and hypolipidemic.

The invention discloses methanesulfonic acid doxazosin controlling releasing tablets and a process for preparation, which contains a single-layer core, insoluble semi-permeable membrane, single drug-releasing eyelet on each side of the tablet, and depends on the osmotic pressure difference between inside and outside of the semi-permeable membrane medium. The invention realizes the control of linear releasing of methanesulfonic acid doxazosin by single-layer core structure, and can remain effective and steady blood and drug concentration. The curative effect is improved, the generation rate ofside effect is reduced, and the productive technology is greatly simplified.

The invention relates to the field of pharmaceutical preparations, and in particular, relates to a polydatin pharmaceutical composition containing no organic solvent and a preparation method thereof.The polydatin pharmaceutical composition comprises polydatin, a solubilizing agent and a solvent. The solubilizing agent is polyethylene glycol dodecyl hydroxy stearate, and the solvent is water for injection or a pH buffer solution or a sodium chloride solution or a glucose solution. According to the polydatin pharmaceutical composition containing no organic solvent, the dosage form is a pharmaceutically acceptable conventional dosage form such as water for injection or pre-serviced water or an aqueous solution freeze-dried product prepared from normal saline. The preparation method of the polydatin pharmaceutical composition mainly comprises the steps of dissolution, filtration, sealed potting, sterilization, lamp examination and the like.

The invention belongs to the technical field of medicines, relates to a novel application of THXM 88-3-3 as a multidrug resistance reversal agent, and concretely relates to a novel application of the THXM 88-3-3 in treating tumors with multidrug resistance and improving the sensitivity of tumor cells to anti-cancer drugs when the THXM 88-3-3 and the anti-cancer drugs are combined. The compound has the beneficial effects that the sensitivity of chemotherapeutic drugs to cancer cells is enhanced, the curative effect of the drugs is enhanced, and THXM 88-3-3 is expected to be developed into the tumor multidrug resistance reversal agent.

The invention discloses a composition containing polydatin and its application, which belongs to the technical field of polydatin application and aims to solve the technical problem of the limited solubility of polydatin in pure water or physiological saline solution. And this kind of polydatin-containing composition adopts composite hydrogel as loading agent, improves the solubility of polydatin in aqueous solution or saline solution, and makes it meet the needs of clinical medicine of polydatin; and the composite hydrogel utilizes Poloxamer has the property of reverse reversible thermal gelation, and the introduction of silk fibroin and carboxymethyl chitosan utilizes the carboxyl group on carboxymethyl chitosan to combine with the amino group on silk fibroin and poloxamer The hydroxyl group on the hydrogel reacts to form an interpenetrating network in the composite gel system, which improves the mechanical strength of the composite hydrogel, and there are hydrophilic segments of silk fibroin and poloxamer in the entire gel system, making the gel ‑Sol transition temperature tends to body temperature, suitable for human administration.

The invention discloses a compound triamcinolone acetonide acetate solution preparation method. According to the method, a solution product with excellent stability is obtained by adding appropriate amount of a sodium chloride aqueous solution; in addition, with adoption of the method, the production cost is low, the safety and effectiveness of the product are not affected, the environmental pollution pressure is not worsened, and industrial production and application are suitable.

An oral disintegrating tablet of flavone aspirin for treating coronary heart disease, angina pectoris, myocarditis, ischemic heart disease, hyperlipemia, etc is disclosed. Its preparing process is also disclosed.

The invention relates to an injection using astragalus root glycosides extract as the active ingredient, which also comprises pharmaceutically acceptable adjunct for injection, the content of the astragalus root glycosides in the total astragalus root extract is 80-100%, each unit of the preparation contains astragalus root glycosides 90-300mg.